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repositories = "e-Repositori UPF" > : "Nature Publishing Group" (x)
1

Found 6 documents, displaying page 1 of 1

Disease-corrected haematopoietic progenitors from Fanconi anemia induced pluripotent stem cells

Author(s) : Rodríguez Pizà, Ignasi , Verma, Inder M. , Veiga, Anna , Aasen, Trond , Izpisúa Belmonte, J. C. , Bueren, Juan , Garreta, Elena
Description : The generation of induced pluripotent stem (iPS) cells has enabled the derivation of patient-specific pluripotent cells and provided valuable experimental platforms to model human disease. Patient-specific iPS cells are also thought to hold great therapeutic potential, although direct evidence for t...
Repository : e-Repositori UPF
Language(s) : English

A protocol describing the genetic correction of somatic human cells and subsequent generation of IPS cell

Author(s) : Rodríguez Pizà, Ignasi , Raya Chamorro, Ángel , Navarro, Susana , Izpisúa Belmonte, J. C. , Bueren, Juan , Consiglio, Antonella
Description : The generation of patient-specific induced pluripotent stem cells (iPSCPSCPSCs) offers unprecedented opportunities for modeling and treating human disease. In combination with gene therapy, the iPSCPSCPSC technology can be used to generate disease-free progenitor cells of potential interest for auto...
Repository : e-Repositori UPF
Language(s) : English

Generation of induced pluripotent stem cells from human cord blood cells with only two factors:OCT4 and SOX2

Author(s) : Rodríguez Pizà, Ignasi , Giorgetti, Alessandra , Izpisúa Belmonte, J. C. , Veiga, Anna , Azqueta, Carmen , Montserrat, Nuria
Description : Induced pluripotent stem cells (iPSC ) provide an invaluable resource for regenerative medicine as they allow the generation of patient-specific progenitors with potential value for cell therapy. However, in many instances, an off-the-shelf approach is desirable, such as for cell therapy of acute co...
Repository : e-Repositori UPF
Language(s) : English

A genomic analysis identifies a novel component in the genetic structure of sub-Saharan African populations

Author(s) : Sikora, Martin , Laayouni, Hafid , Calafell, Francesc , Comas, David , Bertranpetit, Jaume
Description : Studies of large sets of SNP data have proven to be a powerful tool in the analysis of the genetic structure of human populations. In this work, we analyze genotyping data for 2,841 SNPs in 12 Sub-Saharan African populations, including a previously unsampled region of south-eastern Africa (Mozambiqu...
Repository : e-Repositori UPF
Language(s) : English

Lifespan extension by calorie restriction relies on the Sty1 MAP kinase stress pathway

Author(s) : Zuin, Alice , Carmona, Mercè , Morales Ivorra, Isabel , Gabrielli, Natalia , Vivancos Prellezo, Ana , Ayté del Olmo, José
Description : Either calorie restriction, loss of function of the nutrient-dependent PKA or TOR/SCH9 pathways, or activation of stress defences improves longevity in different eukaryotes. However, the molecular links between glucose depletion, nutrient-dependent pathways and stress responses are unknown. Here we ...
Repository : e-Repositori UPF
Language(s) : English

Design and evaluation of a panel os single-nucleotide polymorphisms in microRNA genomic regions for association studies in human disease

Author(s) : Muiños Gimeno, Margarita , Montfort, Magda , Bayés, Mònica , Estivill, Xavier , Espinosa Parrilla, Yolanda
Description : MicroRNAs (miRNA) are recognized posttranscriptional gene repressors involved in the control of almost every biological process. Allelic variants in these regions may be an important source of phenotypic diversity and contribute to disease susceptibility. We analyzed the genomic organization of 325 ...
Repository : e-Repositori UPF
Language(s) : English
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Found 6 documents, displaying page 1 of 1