Results
repositories = "University of Newcastle Library E-Print Archives"
Kava - Using Byte code Rewriting to add Behavioural Reflection in Java
Description :
Many authors have proposed using byte code rewriting as a way of adapting or exending the behaviour of Java classes. There are toolkits available that simplify this process and raise the level of abstration above byte code. However to the best of our knowledge none of these toolkits provide a comple...
Repository :
University of Newcastle Library E-Print Archives
Language(s) :
English
Environmental adversity and uncertainty favour co-operation
Description :
A major cornerstone of evolutionary biology theory is the explanation of the emergence of cooperation in communities of selfish individuals. There is an unexplained tendency in the plant and animal world with examples from alpine plants worms fish mole-rats monkeys and humans for cooperation to flou...
Repository :
University of Newcastle Library E-Print Archives
Language(s) :
English
Primary care management of diabetes in a lowmiddle income country a multi-method qualitative study of barriers and facilitators to care
Description :
The management of patients with diabetes mellitus is complex. Some research has been done in developed countries to attempt to determine the factors that influence quality of care of patients with diabetes Factors thus far postulated are usually categorised into patient clinician and organisational ...
Repository :
University of Newcastle Library E-Print Archives
Language(s) :
English
Preliminary observation of elevated levels of nanocrystalline iron oxide in the basal ganglia of neuroferritinopathy patients
Description :
Magnetometry analysis of brain tissue sub-samples from two neuroferritinopathy patients provides a preliminary indication that the amount of magnetic iron compounds associated with this rare disease is significantly larger than in agesex-matched controls from the same region of the brain. The primar...
Repository :
University of Newcastle Library E-Print Archives
Language(s) :
English
Rapid dental development in a Middle Paleolithic Belgian Neanderthal
Description :
The evolution of life history pace of growth and reproduction was crucial to ancient hominin adaptations. The study of dental development facilitates assessment of growth and development in fossil hominins with greater precision than other skeletal analyses. During tooth formation biological rhythms...
Repository :
University of Newcastle Library E-Print Archives
Language(s) :
English
Generation of a floxed allele of the mouse endoglin gene
Description :
Endoglin is an auxiliary receptor for TGF946 signalling. Heterozygous germline Endoglin mutations have been identified in patients with the vascular abnormality Hereditary Haemorrhagic Telangiectasia. Endoglin is upregulated in endothelial cells during angiogenesis and loss of Endoglin in the mouse ...
Repository :
University of Newcastle Library E-Print Archives
Language(s) :
English
Cdk1 phosphorylation sites on Cdc27 are required for correct chromosomal localisation and APCC function in syncytial Drosophila embryos
Description :
Anaphase-promoting complex or cyclosome APCC controls the metaphase-to-anaphase transition and mitosis exit by triggering the degradation of key cell cycle regulators such as securin and B-type cyclins. However little is known about the functions of individual APCC subunits and how they might regula...
Repository :
University of Newcastle Library E-Print Archives
Language(s) :
English
A direct interaction between TGF946 activated kinase 1 and the TGF946 type II receptor Implications for TGF946 signalling and cardiac hypertrophy
Description :
Transforming growth factor beta TGF946-activated kinase 1 TAK1 is a MAP kinase kinase kinase involved in numerous signalling pathways and is strongly implicated in cardiac hypertrophy and heart failure. TGF946 is also associated with hypertension and heart disease and evidence suggests that TGF9461 ...
Repository :
University of Newcastle Library E-Print Archives
Language(s) :
English
Sensors for impossible stimuli may solve the stereo correspondence problem
Description :
A fundamental challenge of binocular vision is that objects project to different positions on the two retinas binocular disparity. Neurons in visual cortex show two distinct types of tuning to disparity position and phase disparity due to differences in receptive field location and profile respectiv...
Repository :
University of Newcastle Library E-Print Archives
Language(s) :
English
Mrc1 protects uncapped budding yeast telomeres from exonuclease EXO1
Description :
Mrc1 Mediator of Replication Checkpoint 1 is a component of the DNA replication fork machinery and is necessary for checkpoint activation after replication stress. In this study we addressed the role of Mrc1 at uncapped telomeres. Our experiments show that Mrc1 contributes to the vitality of both cd...
Repository :
University of Newcastle Library E-Print Archives
Language(s) :
English