Results
repositories = "DIAL - Dépôt Institutionnel de l'Académie Louvain"
> : "Cambridge Cell Press"
(x)
Deletion and Point Mutations of PTHLH Cause Brachydactyly Type E
Author(s) :
Klopocki, Eva
,
Hennig, Bianca P.
,
Dathe, Katarina
,
Koll, Randi
,
de Ravel, Thomy
,
Baten, Emiel
,
Blom, Eveline
,
Gillerot, Yves
Description :
Autosomal-dominant brachydactyly type E (BDE) is a congenital limb malformation characterized by small hands and feet predominantly as a result of shortened metacarpals and metatarsals. In a large pedigree with BIDE, short stature, and learning disabilities, we detected a microdeletion of similar to...
Repository :
DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) :
English
Organogenesis and Development of the Liver
Description :
Repository :
DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) :
English
Drosophila Genome-wide Obesity Screen Reveals Hedgehog as a Determinant of Brown versus White Adipose Cell Fate
Description :
Over 1 billion people are estimated to be overweight, placing them at risk for diabetes, cardiovascular disease, and cancer. We performed a systems-level genetic dissection of adiposity regulation using genome-wide RNAi screening in adult Drosophila. As a follow-up, the resulting similar to 500 cand...
Repository :
DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) :
English
A Gene-Specific Requirement of RNA Polymerase II CTD Phosphorylation for Sexual Differentiation in S. pombe
Author(s) :
Coudreuse, Damien
,
van Bakel, Harm
,
Dewez, Monique
,
Soutourina, Julie
,
Parnell, Tim
,
Vandenhaute, Jean
,
Cairns, Brad
Description :
Background: The switch from cellular proliferation to differentiation occurs to a large extent through specific programs of gene expression. In fission yeast, the master regulator of sexual differentiation, ste11, is induced by environmental conditions leading to mating and meiosis. Results: We show...
Repository :
DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) :
English
Apelin Stimulates Glucose Utilization in Normal and Obese Insulin-Resistant Mice
Author(s) :
Dray, Cedric
,
Knauf, Claude
,
Daviaud, Daniele
,
Waget, Aurelie
,
Boucher, Jeremie
,
Buleon, Marie
,
Cani, Patrice
,
Attane, Camille
Description :
Adipose tissue (AT) secretes several adipokines that influence insulin sensitivity and potentially link obesity to insulin resistance. Apelin, a peptide present in different tissues, is also secreted by adipocytes. Apelin is upregulated in obese and hyperinsulinemic humans and mice. Although a tight...
Repository :
DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) :
English
The acyclic CB1R inverse agonist taranabant mediates weight loss by increasing energy expenditure and decreasing caloric intake
Author(s) :
Addy, Carol
,
Van Laere, Koen
,
De Lepeleire, Inge
,
Cilissen, Caroline
,
de Hoon, Jan
,
Bormans, Guy M.
,
Depre, Marleen
Description :
Cannabinoid 1 receptor (CB1R) inverse agonists are emerging as a potential obesity therapy. However, the physiological mechanisms by which these agents modulate human energy balance are incompletely elucidated. Here, we describe a comprehensive clinical research study of taranabant, a structurally n...
Repository :
DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) :
English
Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes
Author(s) :
Pospisilik, J. Andrew
,
Knauf, Claude
,
Joza, Nicholas
,
Benit, Paule
,
Orthofer, Michael
,
Cani, Patrice
,
Ebersberger, Ingo
Description :
Type-2 diabetes results from the development of insulin resistance and a concomitant impairment of insulin secretion. Recent studies place altered mitochondrial oxidative phosphorylation (OxPhos) as an underlying genetic element of insulin resistance. However, the causative or compensatory nature of...
Repository :
DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) :
English
Regulation of HIF-1 alpha stability through S-nitrosylation
Author(s) :
Li, Fang
,
Sonveaux, Pierre
,
Rabbani, Zahid N.
,
Liu, Shanling
,
Yan, Bin
,
Huang, Qian
,
Vujaskovic, Zeljko
,
Dewhirst, Mark W.
Description :
Hypoxia-inducible factor 1 (HIF-1) is a master transcriptional factor. Under normal oxygen tension, HIF-1 activity is usually suppressed due to the rapid, oxygen-dependent degradation of one of its two subunits, HIF-1 alpha. Here we report that normoxic HIF-1 activity can be upregulated through NO-m...
Repository :
DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) :
English
Cerebellar LTD and pattern recognition by Purkinje cells
Author(s) :
Steuber, Volker
,
Mittmann, Wolfgang
,
Hoebeek, Freek E.
,
Silver, R. Angus
,
De Zeeuw, Chris I.
,
Hausser, Michael
Description :
Many theories of cerebellar function assume that long-term depression (LTD) of parallel fiber (PF) synapses enables Purkinje cells to learn to recognize PF activity patterns. We have studied the LTD-based recognition of PF patterns in a biophysically realistic Purkinje-cell model. With simple-spike ...
Repository :
DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) :
English
Structure of a 14-3-3 coordinated hexamer of the plant plasma membrane H+-ATPase by combining X-ray crystallography and electron cryomicroscopy
Author(s) :
Ottmann, Christian
,
Marco, Sergio
,
Jaspert, Nina
,
Marcon, Caroline
,
Schauer, Nicolas
,
Weyand, Michael
,
Vandermeeren, Caroline
Description :
Regulatory 14-3-3 proteins activate the plant plasma membrane H+-ATPase by binding to its C-terminal autoinhibitory domain. This interaction requires phosphorylation of a C-terminal, mode III, recognition motif as well as an adjacent span of approximately 50 amino acids. Here we report the X-ray cry...
Repository :
DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) :
English