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author = "Zhang, Xiuqing"
1 2 3 4 5 > >>

Found 48 documents, displaying page 1 of 5

High resolution profiling of human exon methylation by liquid hybridization capture-based bisulfite sequencing

Author(s) : Wang Junwen , Jiang Hui , Ji Guanyu , Gao Fei , Wu Mingzhi , Sun Jihua , Luo Huijuan , Wu Jinghua , Wu Renhua , Zhang Xiuqing
Description :

Abstract

Background

DNA methylation plays important roles in gene regulation during both normal developmental and disease states. In the past decade, a number of methods have been developed and applied to characterize the genome-wide distribution of DNA methylation. Most of these me...

Repository : DOAJ-Articles
Language(s) : English

Comprehensive evaluation of SNP identification with the Restriction Enzyme-based Reduced Representation Library (RRL) method

Author(s) : Du Ye , Jiang Hui , Chen Ying , Li Cong , Zhao Meiru , Wu Jinghua , Qiu Yong , Li Qibin , Zhang Xiuqing
Description :

Abstract

Background

Restriction Enzyme-based Reduced Representation Library (RRL) method represents a relatively feasible and flexible strategy used for Single Nucleotide Polymorphism (SNP) identification in different species. It has remarkable advantage of reducing the complexity o...

Repository : DOAJ-Articles
Language(s) : English

Sequencing bias: comparison of different protocols of MicroRNA library construction

Author(s) : Tian, Geng , Yin, XuYang , Luo, Hong , Xu, XiaoHong , Bolund, Lars , Zhang, XiuQing
Description :
Repository : Europe PubMed Central
Language(s) : English

Comprehensive evaluation of SNP identification with the Restriction Enzyme-based Reduced Representation Library (RRL) method

Author(s) : Du, Ye , Jiang, Hui , Chen, Ying , Li, Cong , Zhao, Meiru , Wu, Jinghua , Qiu, Yong , Li, Qibin , Zhang, Xiuqing
Description :
Repository : Europe PubMed Central
Language(s) : English

An improved method for genome wide DNA methylation profiling correlated to transcription and genomic instability in two breast cancer cell lines

Author(s) : Li Jian , Gao Fei , Li Ning , Li Shengting , Yin Guangliang , Tian Geng , Jia Shangang , Wang Kai , Zhang Xiuqing , Yang Huanming
Description :

Abstract

Background

DNA methylation is a widely studied epigenetic mechanism known to correlate with gene repression and genomic stability. Development of sensitive methods for global detection of DNA methylation events is of particular importance.

Results

We here desc...

Repository : DOAJ-Articles
Language(s) : English

Sequencing bias: comparison of different protocols of MicroRNA library construction

Author(s) : Tian Geng , Yin XuYang , Luo Hong , Xu XiaoHong , Bolund Lars , Zhang XiuQing
Description :

Abstract

Background

MicroRNAs(miRNAs) are 18-25 nt small RNAs playing critical roles in many biological processes. The majority of known miRNAs were discovered by conventional cloning and a Sanger sequencing approach. The next-generation sequencing (NGS) technologies enable in-depth...

Repository : DOAJ-Articles
Language(s) : English

Double restriction-enzyme digestion improves the coverage and accuracy of genome-wide CpG methylation profiling by reduced representation bisulfite sequencing

Author(s) : Wang Junwen , Xia Yudong , Li Lili , Gong Desheng , Yao Yu , Luo Huijuan , Lu Hanlin , Yi Na , Wu Honglong , Zhang Xiuqing , Tao Qian
Description :

Abstract

Background

Reduced representation bisulfite sequencing (RRBS) was developed to measure DNA methylation of high-CG regions at single base-pair resolution, and has been widely used because of its minimal DNA requirements and cost efficacy; however, the CpG coverage of genomic...

Repository : DOAJ-Articles
Language(s) : English

Sequencing bias: comparison of different protocols of MicroRNA library construction

Author(s) : Tian Geng , Gan ShangQuang , Yin XuYang , Luo Hong , Xu XiaoHong , Bolund Lars , Zhang XiuQing , Li Ning
Description :
Repository : DOAJ-Articles
Language(s) : English

Deep RNA sequencing at single base-pair resolution reveals high complexity of the rice transcriptome

Author(s) : Zhang, Guojie , Guo, Guangwu , Hu, Xueda , Zhang, Yong , Li, Qiye , Li, Ruiqiang , Zhuang, Ruhong , Lu, Zhike , He, Zengquan
Description : Understanding the dynamics of eukaryotic transcriptome is essential for studying the complexity of transcriptional regulation and its impact on phenotype. However, comprehensive studies of transcriptomes at single base resolution are rare, even for modern organisms, and lacking for rice. Here, we pr...
Repository : Europe PubMed Central
Language(s) : English

High-Resolution Mapping of Genotype-Phenotype Relationships in Cri du Chat Syndrome Using Array Comparative Genomic Hybridization

Author(s) : Zhang, Xiaoxiao  , Snijders, Antoine  , Segraves, Richard  , Zhang, Xiuqing  , Niebuhr, Anita  , Albertson, Donna  , Yang, Huanming 
Description : We have used array comparative genomic hybridization to map DNA copy–number changes in 94 patients with cri du chat syndrome who had been carefully evaluated for the presence of the characteristic cry, speech delay, facial dysmorphology, and level of mental retardation (MR). Most subjects had simple...
Repository : Europe PubMed Central
Language(s) : English
1 2 3 4 5 > >>

Found 48 documents, displaying page 1 of 5