Results
author = "Zaat, S.A.J."
Platelet microbicidal activity is an important defense factor against viridans streptococcal endocarditis
Description :
Repository :
Publications of the Universiteit van Amsterdam
Language(s) :
Undetermined
Altered gene expression of Staphylococcus aureus upon interaction with human endothelial cells
Author(s) :
Vriesema, A.J.M.
,
Beekhuizen, H.
,
Hamdi, M.
,
Soufan, A.
,
Lammers, A.
,
Willekens, B.
,
Bakker, O.
,
Veltrop, M.H.A.M.
Description :
Staphylococcus aureus is isolated from a substantial number of patients with infective endocarditis who are not known to have predisposing heart abnormalities. It has been suggested that the infection is initiated by the direct binding of S. aureus to human vascular endothelium. To determine the mut...
Repository :
Wageningen University and Researchcenter Publications
Language(s) :
English
Serum Stabilities of Short Tryptophan-and Arginine-Rich Antimicrobial Peptide Analogs
Description :
Background: Several short antimicrobial peptides that are rich in tryptophan and arginine residues were designed with a series of simple modifications such as end capping and cyclization. The two sets of hexapeptides are based on the Trp- and Arg-rich primary sequences from the "antimicrobial centre...
Repository :
Publications of the Universiteit van Amsterdam
Language(s) :
Undetermined
Two Major Medicinal Honeys Have Different Mechanisms of Bactericidal Activity
Author(s) :
Kwakman, P.H.S.
,
Velde, A.A. te
,
Boer, L. de
,
Vandenbroucke-Grauls, C.M.J.E.
,
Zaat, S.A.J.
Description :
Honey is increasingly valued for its antibacterial activity, but knowledge regarding the mechanism of action is still incomplete. We assessed the bactericidal activity and mechanism of action of Revamil (R) source (RS) honey and manuka honey, the sources of two major medical-grade honeys. RS honey k...
Repository :
Publications of the Universiteit van Amsterdam
Language(s) :
Undetermined
Microscopic Detection of Viable Staphylococcus epidermidis in Peri-Implant Tissue in Experimental Biomaterial-Associated Infection, Identified by Bromodeoxyuridine Incorporation ▿
Description :
Infection of biomedical devices is characterized by biofilm formation and colonization of surrounding tissue by the causative pathogens. To investigate whether bacteria detected microscopically in tissue surrounding infected devices were viable, we used bromodeoxyuridine (BrdU), a nucleotide analogu...
Repository :
Europe PubMed Central
Language(s) :
English
Enhanced Susceptibility to Subcutaneous Abscess Formation and Persistent Infection around Catheters Is Associated with Sustained Interleukin-1β Levels
Author(s) :
Boelens, J. J.
,
Zaat, S. A. J.
,
Murk, J. L.
,
Weening, J. J.
,
van der Poll, T.
,
Dankert, J.
Description :
A persistent Staphylococcus epidermidis infection in mice around a subcutaneous polyvinylpyrrolidone-grafted silicon elastomer catheter (SEpvp) but not around a conventional silicon elastomer catheter was observed. With SEpvp pericatheter tissue, protracted and exaggerated interleukin-1β (IL-1β) pro...
Repository :
Europe PubMed Central
Language(s) :
English
Two Major Medicinal Honeys Have Different Mechanisms of Bactericidal Activity
Author(s) :
Kwakman, P.H.S.
,
Velde, A.A.T.
,
Boer, L.
,
Vandenbroucke-Grauls, C.M.J.E.
,
Zaat, S.A.J.
Description :
Repository :
DSpace at Vrije Universiteit Amsterdam
Language(s) :
Undetermined
Nebulized antithrombin limits bacterial outgrowth and lung injury in Streptococcus pneumoniae pneumonia in rats
Author(s) :
Hofstra, J.J.
,
Cornet, A.D.
,
Rooy, B.F. de
,
Vlaar, A.P.
,
Poll, T. van der
,
Levi, M.
,
Zaat, S.A.J.
,
Schultz, M.J.
Description :
Introduction Disturbed alveolar fibrin turnover is a cardinal feature of severe pneumonia. Clinical studies suggest that natural inhibitors of coagulation exert lung-protective effects via anticoagulant and possibly also anti-inflammatory pathways. Intravenous infusion of the natural anticoagulants ...
Repository :
Publications of the Universiteit van Amsterdam
Language(s) :
Undetermined
Comparison of PCR, Culture, and Serological Tests for Diagnosis of Mycoplasma pneumoniae Respiratory Tract Infection in Children
Author(s) :
Dorigo-Zetsma, J. W.
,
Zaat, S. A. J.
,
Wertheim-van Dillen, P. M. E.
,
Spanjaard, L.
,
Rijntjes, J.
,
van Waveren, G.
Description :
For diagnosis of Mycoplasma pneumoniae infection we compared two rapid tests, PCR and the immunoglobulin M immunofluorescence assay (IgM IFA), with culture and the complement fixation test (CFT), in a prospective study among 92 children with respiratory tract infection and 74 controls. Based on posi...
Repository :
Europe PubMed Central
Language(s) :
English
Medical-grade honey enriched with antimicrobial peptides has enhanced activity against antibiotic-resistant pathogens
Author(s) :
Kwakman, P. H. S.
,
de Boer, L.
,
Ruyter-Spira, C. P.
,
Creemers-Molenaar, T.
,
Helsper, J. P. F. G.
,
Vandenbroucke-Grauls, C. M. J. E.
Description :
Honey has potent activity against both antibiotic-sensitive and -resistant bacteria, and is an interesting agent for topical antimicrobial application to wounds. As honey is diluted by wound exudate, rapid bactericidal activity up to high dilution is a prerequisite for its successful application. We...
Repository :
Europe PubMed Central
Language(s) :
English