Results
author = "Wong, Chi-Huey"
Plasma proteome of severe acute respiratory syndrome analyzed by two-dimensional gel electrophoresis and mass spectrometry
Author(s) :
Chen, Jenn-Han
,
Chang, Yu-Wang
,
Yao, Chen-Wen
,
Chiueh, Tzong-Shi
,
Huang, Su-Chin
,
Chien, Ko-Yi
,
Chen, An
,
Chang, Feng-Yee
Description :
We have investigated the plasma proteome by using 2D gel electrophoresis and MS from patients with severe acute respiratory syndrome (SARS). A complete proteomic analysis was performed on four patients with SARS in different time courses, and a total of 38 differential spots were selected for protei...
Repository :
Europe PubMed Central
Language(s) :
English
Ganoderma lucidum polysaccharides in human monocytic leukemia cells: from gene expression to network construction
Author(s) :
Cheng, Kun-Chieh
,
Huang, Hsuan-Cheng
,
Chen, Jenn-Han
,
Hsu, Jia-Wei
,
Cheng, Hsu-Chieh
,
Ou, Chern-Han
,
Yang, Wen-Bin
Description :
Repository :
Europe PubMed Central
Language(s) :
English
Profiling Carbohydrate-Receptor Interaction with Recombinant Innate Immunity Receptor-Fc Fusion Proteins*
Author(s) :
Hsu, Tsui-Ling
,
Cheng, Shih-Chin
,
Yang, Wen-Bin
,
Chin, See-Wen
,
Chen, Bo-Hua
,
Huang, Ming-Ting
,
Hsieh, Shie-Liang
Description :
The recognition of bacteria, viruses, fungi, and other microbes is controlled by host immune cells, which are equipped with many innate immunity receptors, such as Toll-like receptors, C-type lectin receptors, and immunoglobulin-like receptors. Our studies indicate that the immune modulating propert...
Repository :
Europe PubMed Central
Language(s) :
English
In Vivo Protection Provided by a Synthetic New Alpha-Galactosyl Ceramide Analog against Bacterial and Viral Infections in Murine Models▿
Author(s) :
Lin, Kun-Hsien
,
Liang, Jian-Jong
,
Huang, Wen-I
,
Lin-Chu, Shao-Ying
,
Su, Ching-Yao
,
Lee, Yi-Ling
,
Jan, Jia-Tsong
,
Lin, Yi-Ling
Description :
Alpha-galactosyl ceramide (α-GalCer) has been known to bind to the CD1d receptor on dendritic cells and activate invariant natural killer T (iNKT) cells, which subsequently secrete T-helper-cell 1 (Th1) and Th2 cytokines, which correlate with anti-infection activity and the prevention of autoimmune ...
Repository :
Europe PubMed Central
Language(s) :
English
Broadly neutralizing DNA vaccine with specific mutation alters the antigenicity and sugar-binding activities of influenza hemagglutinin
Author(s) :
Chen, Ming-Wei
,
Liao, Hsin-Yu
,
Huang, Yaoxing
,
Jan, Jia-Tsrong
,
Huang, Chih-Cheng
,
Ren, Chien-Tai
,
Wu, Chung-Yi
,
Cheng, Ting-Jen Rachel
Description :
The rapid genetic drift of influenza virus hemagglutinin is an obstacle to vaccine efficacy. Previously, we found that the consensus hemagglutinin DNA vaccine (pCHA5) can only elicit moderate neutralization activities toward the H5N1 clade 2.1 and clade 2.3 viruses. Two approaches were thus taken to...
Repository :
Europe PubMed Central
Language(s) :
English
Avidity of CD1d-ligand-receptor ternary complex contributes to T-helper 1 (Th1) polarization and anticancer efficacy
Author(s) :
Wu, Tai-Na
,
Lin, Kun-Hsien
,
Chang, Ya-Jen
,
Huang, Jing-Rong
,
Cheng, Jing-Yan
,
Yu, Alice L.
,
Wong, Chi-Huey
Description :
Invariant natural killer T cell (NKT) cells (iNKT cells) produce both T-helper 1 (Th1) and T-helper 2 cytokines in response to α-Galactosylceramide (α-GalCer) stimulation and are thought to be the important effectors in the regulation of both innate and adaptive immunity involved in autoimmune disor...
Repository :
Europe PubMed Central
Language(s) :
English
Modulation of Substrate Specificities of d-Sialic Acid Aldolase through Single Mutations of Val-251*
Author(s) :
Chou, Chien-Yu
,
Ko, Tzu-Ping
,
Wu, Kuan-Jung
,
Huang, Kai-Fa
,
Lin, Chun-Hung
,
Wong, Chi-Huey
,
Wang, Andrew H.-J.
Description :
In a recent directed-evolution study, Escherichia coli d-sialic acid aldolase was converted by introducing eight point mutations into a new enzyme with relaxed specificity, denoted RS-aldolase (also known formerly as l-3-deoxy-manno-2-octulosonic acid (l-KDO) aldolase), which showed a preferred sele...
Repository :
Europe PubMed Central
Language(s) :
English
Crystal structure of Staphylococcus aureus transglycosylase in complex with a lipid II analog and elucidation of peptidoglycan synthesis mechanism
Author(s) :
Huang, Chia-Ying
,
Shih, Hao-Wei
,
Lin, Li-Ying
,
Tien, Yi-Wen
,
Cheng, Ting-Jen Rachel
,
Cheng, Wei-Chieh
,
Wong, Chi-Huey
Description :
Bacterial transpeptidase and transglycosylase on the surface are essential for cell wall synthesis, and many antibiotics have been developed to target the transpeptidase; however, the problem of antibiotic resistance has arisen and caused a major threat in bacterial infection. The transglycosylase h...
Repository :
Europe PubMed Central
Language(s) :
English
Expression of 5-lipoxygenase and leukotriene A4 hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability
Author(s) :
Qiu, Hong
,
Gabrielsen, Anders
,
Agardh, Hanna E.
,
Wan, Min
,
Wetterholm, Anders
,
Wong, Chi-Huey
,
Hedin, Ulf
,
Swedenborg, Jesper
Description :
Leukotrienes (LT) are a group of proinflammatory lipid mediators that are implicated in the pathogenesis and progression of atherosclerosis. Here we report that mRNA levels for the three key proteins in LTB4 biosynthesis, namely 5-lipoxygenase (5-LO), 5-LO-activating protein (FLAP), and LTA4 hydrola...
Repository :
Europe PubMed Central
Language(s) :
English
Potent immune-modulating and anticancer effects of NKT cell stimulatory glycolipids
Author(s) :
Chang, Ya-Jen
,
Huang, Jing-Rong
,
Tsai, Yi-Chien
,
Hung, Jung-Tung
,
Wu, Douglass
,
Fujio, Masakazu
,
Wong, Chi-Huey
,
Yu, Alice L.
Description :
α-Galactosylceramide (α-GalCer), a glycolipid that stimulates natural killer T (NKT) cells to produce both T helper (Th)1 and Th2 cytokines, has shown antitumor effects in mice but failed in clinical trials. We evaluated 16 analogs of α-GalCer for their CD1-mediated T cell receptor (TCR) activation ...
Repository :
Europe PubMed Central
Language(s) :
English