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author = "Wittmann, Valentin"
<< < 2 3 4 5 6 > >>

Found 59 documents, displaying page 4 of 6

Azides in Carbohydrate Chemistry

Author(s) : Beckmann, Henning S. G. , Wittmann, Valentin
Description :
Repository : Univ. Konstanz: Konstanzer Online-Publikations-System (KOPS)
Language(s) : English

One-Pot Procedure for Diazo Transfer and Azide-Alkyne Cycloaddition : Triazole Linkages from Amines

Author(s) : Beckmann, Henning S. G. , Wittmann, Valentin
Description : A one-pot reaction for Cu(II)-catalyzed diazo transfer and Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition (sometimes called click reaction) is reported. 1,4-Disubstituted 1,2,3-triazoles are obtained in excellent yields from a variety of readily available amines without the need for isolatio...
Repository : Univ. Konstanz: Konstanzer Online-Publikations-System (KOPS)
Language(s) : English

1H-Tetrazole as Catalyst in Phosphomorpholidate Coupling Reactions : Efficient Synthesis of GDP-Fucose, GDP-Mannose, and UDP-Galactose

Author(s) : Wittmann, Valentin , Wong, Chi-Huey
Description : An improved procedure is described for the efficient and high-yield (76-91%) synthesis of nucleoside diphosphate sugars from the readily available nucleoside 5'-monophosphomorpholidate and sugar 1-phosphate in the presence of 1H-tetrazole. Comparative kinetic investigations by means of (31)P NMR spe...
Repository : Univ. Konstanz: Konstanzer Online-Publikations-System (KOPS)
Language(s) : English

Temporary attachment of carbohydrates to cyclopeptide templates : a new strategy for single-bead analysis of multivalent neoglycopeptides

Author(s) : Wittmann, Valentin , Seeberger, Sonja , Schägger, Hermann
Description : Employing a cleavable carbohydrate peptide linker, a new strategy for single-bead analysis of multivalent cyclic neoglycopeptides based on Edman degradation is described. Edman degradation of glycopeptides is hampered by the acid lability of the glycosidic bond and potential incompatibilities of phe...
Repository : Univ. Konstanz: Konstanzer Online-Publikations-System (KOPS)
Language(s) : English

Probing multivalent carbohydrate-lectin interactions by an enzyme-linked lectin assay employing covalently immobilized carbohydrates

Author(s) : Maierhofer, Caroline , Rohmer, Katja , Wittmann, Valentin
Description : We report here the synthesis of a series of mono- to trivalent N-acetylglucosamine (GlcNAc) derivatives as ligands for the plant lectin wheat germ agglutinin (WGA). Their WGA binding potencies were determined by an established enzyme-linked lectin assay (ELLA) employing microtiter plates with non-co...
Repository : Univ. Konstanz: Konstanzer Online-Publikations-System (KOPS)
Language(s) : English

Stereoselective synthesis of 1,10-linked a-L-lyxopyranosyl b-D-glucopyranoside, the proposed biosynthetic precursor of the FG ring system of avilamycins

Author(s) : Schmidt, Magnus S. , Wittmann, Valentin
Description : The non-reducing disaccharide b-D-Glcp-(1M1)-a-L-Lyxp 1 had been proposed to be an early intermediate during the biosynthesis of avilamycin A [Boll, R.; Hofmann, C.; Heitmann, B.; Hauser, G.; Glaser, S.; Koslowski, T.; Friedrich, T.; Bechthold, A. J. Biol. Chem. 2006, 281, 14756 14763]. This work de...
Repository : Univ. Konstanz: Konstanzer Online-Publikations-System (KOPS)
Language(s) : English

Mechanistische Untersuchung multivalenter Kohlenhydrat-Protein-Wechselwirkungen durch EPR-Spektroskopie

Author(s) : Braun, Patrick , Nägele, Bettina , Wittmann, Valentin , Drescher, Malte
Description : Durch Abstandsmessungen mit Spinsonden-EPR-Spektroskopie gelang der direkte Nachweis multivalenter Protein-Ligand-Interaktionen in Lösung. Man erhält ein detailliertes Bild des Mechanismus der Bindung divalenter Liganden an ein Lectin. Chelatbindung lässt sich so von monovalentem Binden mehrerer Mol...
Repository : Univ. Konstanz: Konstanzer Online-Publikations-System (KOPS)
Language(s) : German

Mechanism of multivalent carbohydrate-protein interactions studied by EPR spectroscopy

Author(s) : Braun, Patrick , Nägele, Bettina , Wittmann, Valentin , Drescher, Malte
Description : From a distance: Distance measurements in the nanometer range by means of spin-label electron paramagnetic resonance provide structural evidence for multivalent protein–ligand interactions in solution (see picture; protein subunits: blue/green, ligand: black, spin labels: yellow circles, binding sit...
Repository : Univ. Konstanz: Konstanzer Online-Publikations-System (KOPS)
Language(s) : English

Carba-sugars Activate the glmS-Riboswitch of Staphylococcus aureus

Author(s) : Lünse, Christina E. , Schmidt, Magnus S. , Wittmann, Valentin , Mayer, Günter
Description : The glmS-riboswitch is unique among riboswitch families as it represents a metabolite-dependent ribozyme that undergoes self-cleavage upon recognition of glucosamin-6-phosphate. The glmS-riboswitch is located in the 5′-untranslated region of bacterial genes involved in cell wall biosynthesis. Theref...
Repository : Univ. Konstanz: Konstanzer Online-Publikations-System (KOPS)
Language(s) : English

High-affinity multivalent wheat germ agglutinin ligands by one-pot click reaction

Author(s) : Beckmann, Henning S. G. , Möller, Heiko M. , Wittmann, Valentin
Description :
Repository : Univ. Konstanz: Konstanzer Online-Publikations-System (KOPS)
Language(s) : English
<< < 2 3 4 5 6 > >>

Found 59 documents, displaying page 4 of 6