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author = "Webster, R G"
<< < 2 3 4 5 6 > >>

Found 101 documents, displaying page 4 of 11

Mutations in the hemagglutinin receptor-binding site can change the biological properties of an influenza virus.

Author(s) : Naeve, C W , Hinshaw, V S , Webster, R G
Description : Avian influenza virus reassortants containing human influenza virus hemagglutinins do not replicate in ducks. Two mutations in the receptor-binding site of a human hemagglutinin at residues 226 and 228 allowed replication in ducks. The mutations resulted in a receptor-binding-site sequence identical...
Repository : Europe PubMed Central
Language(s) : English

Antigenic variation of influenza A virus nucleoprotein detected with monoclonal antibodies.

Author(s) : van Wyke, K L , Hinshaw, V S , Bean, W J , Webster, R G
Description : Monoclonal antibodies were used to study antigenic variation in the nucleoprotein of influenza A viruses. We found that the nucleoprotein molecule of the WSN/33 strain possesses at least five different determinants. Viruses of other influenza A virus subtypes showed antigenic variation in these nucl...
Repository : Europe PubMed Central
Language(s) : English

The B-cell response in lymphoid tissue of mice immunized with various antigenic forms of the influenza virus hemagglutinin.

Author(s) : Justewicz, D M , Doherty, P C , Webster, R G
Description : Protection of BALB/c (H-2d) mice against secondary challenge with influenza A viruses is primarily dependent on appropriate recognition of the hemagglutinin (HA) molecule by effectors of humoral immunity, the B lymphocytes and their product the immunoglobulin molecules. The influence of the antigeni...
Repository : Europe PubMed Central
Language(s) : English

Analysis of the evolution and variation of the human influenza A virus nucleoprotein gene from 1933 to 1990.

Author(s) : Shu, L L , Bean, W J , Webster, R G
Description : This study examined the evolution and variation of the human influenza virus nucleoprotein gene from the earliest isolates to the present. Phylogenetic reconstruction of the most parsimonious evolutionary path connecting 49 nucleoprotein sequences yielded a single lineage. The average calculated rat...
Repository : Europe PubMed Central
Language(s) : English

Evolutionary analysis of the influenza A virus M gene with comparison of the M1 and M2 proteins.

Author(s) : Ito, T , Gorman, O T , Kawaoka, Y , Bean, W J , Webster, R G
Description : Phylogenetic analysis of 42 membrane protein (M) genes of influenza A viruses from a variety of hosts and geographic locations showed that these genes have evolved into at least four major host-related lineages: (i) A/Equine/prague/56, which has the most divergent M gene; (ii) a lineage containing o...
Repository : Europe PubMed Central
Language(s) : English

Replication of avian influenza A viruses in mammals.

Author(s) : Hinshaw, V S , Webster, R G , Easterday, B C , Bean, W J
Description : The recent appearance of an avian influenza A virus in seals suggests that viruses are transmitted from birds to mammals in nature. To examine this possibility, avian viruses of different antigenic subtypes were evaluated for their ability to replicate in three mammals-pigs, ferrets, and cats. In ea...
Repository : Europe PubMed Central
Language(s) : English

The origin of pandemic influenza

Author(s) : Webster, R. G. , Laver, W. G.
Description : Serological tests, using antisera specific to the surface subunits of the viruses (e.g., antisera to the haemagglutinin subunits devoid of any antineuraminidase or anti-host antigen activity) showed that the haemagglutinin subunits of the Hong Kong virus were, immunologically, distinct from the subu...
Repository : Europe PubMed Central
Language(s) : English

Antibodies to human influenzavirus neuraminidase (the A/Asian/57 H2N2 strain) in sera from Australian pelagic birds*

Author(s) : Laver, W. G. , Webster, R. G.
Description : Sera collected from Australian pelagic birds specifically inhibited the neuraminidase of the Asian/57 (H2N2) strain of human influenzavirus. Neuraminidase inhibition titres of some sera were high and the avidity of the inhibitor was comparable to that of specific antibody. The neuraminidase of A/Hon...
Repository : Europe PubMed Central
Language(s) : English

Glycosylation affects cleavage of an H5N2 influenza virus hemagglutinin and regulates virulence.

Author(s) : Deshpande, K L , Fried, V A , Ando, M , Webster, R G
Description : Based on nucleotide sequence analysis of the hemagglutinin (HA) gene from the virulent and avirulent A/chicken/Pennsylvania/83 influenza viruses, it was previously postulated that acquisition of virulence was associated with a point mutation that resulted in loss of a glycosylation site. Since there...
Repository : Europe PubMed Central
Language(s) : English

The corneal endothelium and Descemet's membrane in the iridocorneal endothelial syndrome.

Author(s) : Portis, J M , Stamper, R L , Spencer, W H , Webster, R G
Description : A 39-year-old woman with progressive left unilateral glaucoma associated with corneal edema, iris changes, and peripheral anterior synechia formation underwent a left trabeculectomy and iridectomy in an attempt to control the intraocular pressure. Shortly after surgery the edema worsened despite low...
Repository : Europe PubMed Central
Language(s) : English
<< < 2 3 4 5 6 > >>

Found 101 documents, displaying page 4 of 11