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author = "Wasylyk, C"
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Found 19 documents, displaying page 1 of 2

Short and long range activation by the SV40 enhancer.

Author(s) : Wasylyk, B , Wasylyk, C , Chambon, P
Description : Activation of transcription by the SV40 enhancer decreases in an apparently biphasic manner when DNA sequences are interposed between the SV40 enhancer and either the homologous SV40 early or the heterologous conalbumin promoter elements. With increasing lengths of short DNA fragments (up to about 1...
Repository : Europe PubMed Central
Language(s) : English

The immunoglobulin heavy-chain B-lymphocyte enhancer efficiently stimulates transcription in non-lymphoid cells.

Author(s) : Wasylyk, C , Wasylyk, B
Description : The mouse immunoglobulin heavy-chain (IgH) B-lymphocyte enhancer stimulates transcription from heterologous promoters 20- to 40-fold when transfected into several non-lymphoid cell lines. Stimulation in B-lymphocyte melanoma cell-lines is only about 5--10 times better. A central sequence is equally ...
Repository : Europe PubMed Central
Language(s) : English

Oncogenic conversion of Ets affects redox regulation in-vivo and in-vitro.

Author(s) : Wasylyk, C , Wasylyk, B
Description : The avian acute leukemia virus E26 encodes a fusion protein between viral Gag and the cellular transcription factors cMyb and cEts1(p68). vEts on its own transforms more mature erythroid cells. We have compared the properties of vEts and cEts1(p68). vEts interacts preferentially with an antibody tha...
Repository : Europe PubMed Central
Language(s) : English

Transcription from the SV40 early-early and late-early overlapping promoters in the absence of DNA replication.

Author(s) : Wasylyk, B , Wasylyk, C , Matthes, H , Wintzerith, M , Chambon, P
Description : Transcription for a hybrid SV40 promoter-beta globin coding sequence recombinant initiates from both early-early (EE) and late-early (LE) SV40 start sites (EES and LES) in the absence of DNA replication. The 72-bp repeat is essential to potentiate the elements of the two overlapping EE and LE promot...
Repository : Europe PubMed Central
Language(s) : English

Transforming but not immortalizing oncogenes activate the transcription factor PEA1.

Author(s) : Wasylyk, C , Imler, J L , Wasylyk, B
Description : The transcription factor PEA1 (a homologue of AP1 and c-jun) is highly active in several fibroblast cell lines, compared to its low activity in a myeloma and an embryo-carcinoma (EC) cell line. Serum components are essential to attain these high levels of PEA1 activity in fibroblasts. This serum req...
Repository : Europe PubMed Central
Language(s) : English

Cell-specific regulation of oncogene-responsive sequences of the c-fos promoter.

Author(s) : Gutman, A , Wasylyk, C , Wasylyk, B
Description : We have identified oncogene-responsive sequences in the human c-fos promoter that mediate induction of transcription by several nonnuclear oncoproteins and the tumor promoter TPA. These sequences are regulated in a cell-specific manner. (i) In NIH 3T3 cells, the CArG box of the c-fos promoter is suf...
Repository : Europe PubMed Central
Language(s) : English

Interaction of Ets-1 and the POU-homeodomain protein GHF-1/Pit-1 reconstitutes pituitary-specific gene expression.

Author(s) : Bradford, A P , Wasylyk, C , Wasylyk, B , Gutierrez-Hartmann, A
Description : The pituitary-specific, POU-homeodomain factor GHF-1/Pit-1 is necessary, but not sufficient, for cell-specific expression of prolactin (PRL), growth hormone (GH), and thyrotropin. Combinatorial interactions of GHF-1 with other factors are likely to be required; however, such factors and their mechan...
Repository : Europe PubMed Central
Language(s) : English

Negative and positive factors determine the activity of the polyoma virus enhancer alpha domain in undifferentiated and differentiated cell types.

Author(s) : Wasylyk, B , Imler, J L , Chatton, B , Schatz, C , Wasylyk, C
Description : The host range of polyoma virus is dependent upon the activity of its enhancer, which is inactive in undifferentiated embryonal carcinoma cells, such as F9 cells, and is active after their differentiation. We show here that the activity of the alpha domain of the polyoma virus enhancer displays a si...
Repository : Europe PubMed Central
Language(s) : English

Expression of raf oncogenes activates the PEA1 transcription factor motif.

Author(s) : Wasylyk, C , Wasylyk, B , Heidecker, G , Huleihel, M , Rapp, U R
Description : PEA1 (AP1) motif transcription enhancer activity was stimulated by v-raf and more efficiently by activated c-raf-1 or A-raf than by their normal counterparts, in agreement with a role for PEA1 in transformation by raf. Mutations in the ATP-binding site of v-raf prevented activation, suggesting that ...
Repository : Europe PubMed Central
Language(s) : English

Negative regulation contributes to tissue specificity of the immunoglobulin heavy-chain enhancer.

Author(s) : Imler, J L , Lemaire, C , Wasylyk, C , Wasylyk, B
Description : We have identified in and around the immunoglobulin heavy-chain enhancer two apparently distinct negative regulatory elements which repress immunoglobulin H enhancer, simian virus 40 enhancer, and heterologous promoter activity in fibroblasts but not in myeloma cells. We propose that in nonlymphoid ...
Repository : Europe PubMed Central
Language(s) : English
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Found 19 documents, displaying page 1 of 2