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author = "Voets, T."
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Found 7 documents, displaying page 1 of 1

Potent block of volume-activated chloride currents in endothelial cells by the uncharged form of quinine and quinidine.

Description : 1. The effects of quinine and quinidine on the volume-activated chloride current (ICl(vol)) in cultured endothelial cells from bovine pulmonary artery were studied by use of the whole-cell patch-clamp technique. 2. At pH 7.4 both quinine and quinidine induced a fast and reversible block of ICl(vol))...
Repository : Europe PubMed Central
Language(s) : English

Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4

Description : TRPV4 is a Ca2+- and Mg2+-permeable cation channel within the vanilloid receptor subgroup of the transient receptor potential (TRP) family, and it has been implicated in Ca2+-dependent signal transduction in several tissues, including brain and vascular endothelium. TRPV4-activating stimuli include ...
Repository : Europe PubMed Central
Language(s) : English

Homo- and heterotetrameric architecture of the epithelial Ca2+ channels TRPV5 and TRPV6

Description : The molecular assembly of the epithelial Ca2+ channels (TRPV5 and TRPV6) was investigated to determine the subunit stoichiometry and composition. Immunoblot analysis of Xenopus laevis oocytes expressing TRPV5 and TRPV6 revealed two specific bands of 75 and 85–100 kDa, corresponding to the core and g...
Repository : Europe PubMed Central
Language(s) : English

Modulation of synaptic plasticity and Tau phosphorylation by wild-type and mutant presenilin1

Description : The function of presenilin1 (PS1) in intra-membrane proteolysis is undisputed, as is its role in neurodegeneration in FAD, in contrast to its exact function in normal conditions. In this study, we analyzed synaptic plasticity and its underlying mechanisms biochemically in brain of mice with a neuron...
Repository : DI-fusion
Language(s) : English

Trpv5/6 is vital for epithelial calcium uptake and bone formation

Description : Calcium is an essential ion serving a multitude of physiological roles. Aside from its role as a second messenger, it is an essential component of the vertebrate bone matrix. Efficient uptake and storage of calcium are therefore indispensable for all vertebrates. Transient receptor potential family,...
Repository : Wageningen University and Researchcenter Publications
Language(s) : English
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Found 7 documents, displaying page 1 of 1