Results
author = "Vassart, G"
An unusually long poly(purine)-poly(pyrimidine) sequence is located upstream from the human thyroglobulin gene.
Description :
A region of human genomic DNA encompassing the 5' end of the thyroglobulin gene has been sequenced and the position of the transcriptional start site has been determined. The 5' non-translated portion of the mRNA displays a quasi-palindromic sequence which could allow this region to adopt a hairpin ...
Repository :
Europe PubMed Central
Language(s) :
English
Thyrotropin controls transcription of the thyroglobulin gene.
Description :
The availability of rat thyroglobulin cDNA clones was exploited to study the regulation of thyroglobulin gene transcription by thyrotropin (TSH). Groups of rats were subjected to treatments leading to reduction or increase in the rat serum TSH (rTSH) levels. Thyroid gland nuclei were isolated, incub...
Repository :
Europe PubMed Central
Language(s) :
English
Cloning and sequencing of a calcium-binding protein regulated by cyclic AMP in the thyroid.
Description :
p24 is a thyroid protein (Mr 24,000) identified by two-dimensional gel electrophoresis on the basis that its synthesis and phosphorylation are up-regulated by thyrotropin and cyclic AMP agonists. p24 cDNA was cloned from a lambda gt11 cDNA library using a polyclonal antibody raised against the prote...
Repository :
Europe PubMed Central
Language(s) :
English
Abnormal cellular localization of thyroglobulin mRNA associated with hereditary congenital goiter and thyroglobulin deficiency.
Description :
The goiters in a breed of hypothyroid goats contain only minute amounts of thyroblobulin-related antigens (0.01% of normal value). We have analyzed these goiters for the presence of mRNA coding for thyroglobulin. Using DNA complementary to beef 33S thyroglobulin mRNA as a probe, we found that the mR...
Repository :
Europe PubMed Central
Language(s) :
English
Complete nucleotide sequence of the human thyroperoxidase-microsomal antigen cDNA.
Description :
Repository :
Europe PubMed Central
Language(s) :
English
A 3' splice site mutation in the thyroglobulin gene responsible for congenital goiter with hypothyroidism.
Author(s) :
Ieiri, T
,
Cochaux, P
,
Targovnik, H M
,
Suzuki, M
,
Shimoda, S
,
Perret, J
,
Vassart, G
Description :
A case of congenital goiter with defective thyroglobulin synthesis has been studied in molecular terms. The patient is the fifth of a kindred of six, three of which have a goiter. The parents are first cousins. Segregation of thyroglobulin alleles in the family was studied by Southern blotting with ...
Repository :
Europe PubMed Central
Language(s) :
English
INTERPRETATION OF SURFACE ASPECTS OF CELL SECTIONS
Description :
Repository :
Europe PubMed Central
Language(s) :
English
Thyroperoxidase, an auto-antigen with a mosaic structure made of nuclear and mitochondrial gene modules.
Description :
A lambda gt11 cDNA library was constructed from a normal human thyroid and screened with a rabbit anti-porcine thyroperoxidase antibody. A series of thyroperoxidase (TPO) clones were obtained which allowed determination of the complete primary structure of the protein. The library was also screened ...
Repository :
Europe PubMed Central
Language(s) :
English
A sequence in M13 phage detects hypervariable minisatellites in human and animal DNA.
Author(s) :
Vassart, G.
,
Georges, Michel
,
Monsieur, R.
,
Brocas, H.
,
Lequarré, Anne-Sophie
,
Christophe, D.
Description :
The term "DNA fingerprint" has been used to describe the extensive restriction fragment length polymorphism associated with hypervariable minisatellites present in the human genome. Until now, it was necessary to hybridize Southern blots to specific probes cloned from human genomic DNA in order to o...
Repository :
ORBi (University of Liège)
Language(s) :
English
Genetic immunization of outbred mice with thyrotropin receptor cDNA provides a model of Graves' disease.
Author(s) :
Costagliola, S
,
Denef, Jean-François
,
Many, Marie-Christine
,
Pohlenz, J
,
Refetoff, S.
,
Vassart, G.
Description :
We performed genetic immunization of outbred NMRI mice, using a cDNA encoding the human thyrotropin receptor (TSHr). All mice produced antibodies capable of recognizing the recombinant receptor expressed at the surface of stably transfected Chinese hamster ovary (CHO) cells, and sera from most of th...
Repository :
DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) :
English