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author = "Varmus, Harold E."
1 2 3 4 5 > >>

Found 46 documents, displaying page 1 of 5

Dexamethasone Induction of the Intracellular RNAs of Mouse Mammary Tumor Virus

Author(s) : Robertson, Donald L. , Varmus, Harold E.
Description : We have studied the kinetics of dexamethasone induction of mouse mammary tumor virus (MMTV) RNAs and proteins in virus-infected rat XC cells and GR mouse mammary tumor cells. A detectable increase in viral RNA in infected XC cells was present within 10 min after hormone addition, and half-maximal in...
Repository : Europe PubMed Central
Language(s) : English

Cell-Specific Transduction of Prdm1-Expressing Lineages Mediated by a Receptor for Avian Leukosis Virus Subgroup B▿ †

Author(s) : Asimakopoulos, Fotis , Varmus, Harold E.
Description : The transcription factor Blimp-1 has emerged as a regulator of cell fate in embryonic (germ cell) and adult (B- and T-cell immune effector and epithelial) lineages. It has also been proposed to act as a tumor suppressor in B-cell malignancy. Here, we present a novel in vivo system enabling the targe...
Repository : Europe PubMed Central
Language(s) : English

Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in mice

Author(s) : Holland, Eric C. , Varmus, Harold E.
Description : Basic fibroblast growth factor (bFGF) is overexpressed in most high-grade human gliomas, implying that it is involved in the pathogenesis of these tumors. To assess the biological effect of inappropriate production of bFGF in normal astrocytes, we developed a system for glia-specific gene transfer i...
Repository : Europe PubMed Central
Language(s) : English

Evolution of somatic mutations in mammary tumors in transgenic mice is influenced by the inherited genotype

Author(s) : Podsypanina Katrina , Li Yi , Varmus Harold E
Description :

Abstract

Background

MMTV-Wnt1 transgenic mice develop mammary hyperplasia early in development, followed by the appearance of solitary mammary tumors with a high proportion of cells expressing early lineage markers and many myoepithelial cells. The occurrence of tumors is a...

Repository : DOAJ-Articles
Language(s) : English

The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancer

Author(s) : Lewis, Brian C. , Klimstra, David S. , Varmus, Harold E.
Description : We have generated a mouse model for pancreatic cancer through the somatic delivery of oncogene-bearing avian retroviruses to mice that express TVA, the receptor for avian leukosis sarcoma virus subgroup A (ALSV-A), under the control of the elastase promoter. Delivery of ALSV-A-based RCAS vectors enc...
Repository : Europe PubMed Central
Language(s) : English

Integration of Deoxyribonucleic Acid Specific for Rous Sarcoma Virus after Infection of Permissive and Nonpermissive Hosts

Author(s) : Varmus, Harold E. , Vogt, Peter K. , Bishop, J. Michael
Description : A relatively simple but stringent technique was developed to detect the integration of virus-specific DNA into the genomes of higher organisms. In both permissive (duck) and nonpermissive (mammalian) cells which normally contain no nucleotide sequences specific for Rous sarcoma virus, transformation...
Repository : Europe PubMed Central
Language(s) : English

The Classic: Integration of Deoxyribonucleic Acid Specific for Rous Sarcoma Virus after Infection of Permissive and Nonpermissive Hosts: (RNA tumor viruses/reassociation kinetics/duck cells)

Author(s) : Varmus, Harold E. , Vogt, Peter K. , Bishop, J. Michael
Description : A relatively simple but stringent technique was developed to detect the integration of virus-specific DNA into the genomes of higher organisms. In both permissive (duck) and nonpermissive (mammalian) cells which normally contain no nucleotide sequences specific for Rous sarcoma virus, transformation...
Repository : Europe PubMed Central
Language(s) : English

Erratum: The Classic: Integration of Deoxyribonucleic Acid Specific for Rous Sarcoma Virus after Infection of Permissive and Nonpermissive Hosts: (RNA tumor viruses/reassociation kinetics/duck cells)

Author(s) : Varmus, Harold E. , Vogt, Peter K. , Bishop, J. Michael
Description :
Repository : Europe PubMed Central
Language(s) : English

Oncogene cooperation in tumor maintenance and tumor recurrence in mouse mammary tumors induced by Myc and mutant Kras

Author(s) : Podsypanina, Katrina , Politi, Katerina , Beverly, Levi J. , Varmus, Harold E.
Description : Most, if not all, cancers are composed of cells in which more than one gene has a cancer-promoting mutation. Although recent evidence has shown the benefits of therapies targeting a single mutant protein, little attention has been given to situations in which experimental tumors are induced by multi...
Repository : Europe PubMed Central
Language(s) : English

Use of DNA-DNA Annealing to Detect New Virus-Specific DNA Sequences in Chicken Embryo Fibroblasts After Infection by Avian Sarcoma Virus

Author(s) : Varmus, Harold E. , Heasley, Suzanne , Bishop, J. Michael
Description : Labeled, virus-specific DNA synthesized in vitro by the virion-associated polymerase of avian sarcoma virus (ASV) was used to measure virus-specific sequences in cell DNA in three ways: (i) by determining the effect of cell DNA upon the reassociation rate of double-stranded polymerase products; (ii)...
Repository : Europe PubMed Central
Language(s) : English
1 2 3 4 5 > >>

Found 46 documents, displaying page 1 of 5