Results
author = "Varmus, Harold E."
Lung adenocarcinomas induced in mice by mutant EGF receptors foundin human lung cancers respondto a tyrosine kinase inhibitor orto down-regulation of the receptors
Author(s) :
Politi, Katerina
,
Zakowski, Maureen F.
,
Fan, Pang-Dian
,
Schonfeld, Emily A.
,
Pao, William
,
Varmus, Harold E.
Description :
Somatic mutations in exons encoding the tyrosine kinase domain of the epidermal growth factor receptor (EGFR) gene are found in human lung adenocarcinomas and are associated with sensitivity to the tyrosine kinase inhibitors gefitinib and erlotinib. Nearly 90% of the EGFR mutations are either short,...
Repository :
Europe PubMed Central
Language(s) :
English
Regulation of dorsal fate in the neuraxis by Wnt-1 and Wnt-3a
Description :
Members of the Wnt family of signaling molecules are expressed differentially along the dorsal–ventral axis of the developing neural tube. Thus we asked whether Wnt factors are involved in patterning of the nervous system along this axis. We show that Wnt-1 and Wnt-3a, both of which are expressed in...
Repository :
Europe PubMed Central
Language(s) :
English
The Absence of p53 Promotes Metastasis in a Novel Somatic Mouse Model for Hepatocellular Carcinoma†
Author(s) :
Lewis, Brian C.
,
Klimstra, David S.
,
Socci, Nicholas D.
,
Xu, Su
,
Koutcher, Jason A.
,
Varmus, Harold E.
Description :
We have generated a mouse model for hepatocellular carcinoma using somatic delivery of oncogene-bearing avian retroviral vectors to the liver cells of mice expressing the viral receptor TVA under the control of the albumin gene promoter (Alb-TVA mice). Viruses encoding mouse polyoma virus middle T a...
Repository :
Europe PubMed Central
Language(s) :
English
Detection of Avian Tumor Virus-Specific Nucleotide Sequences in Avian Cell DNAs
Author(s) :
Varmus, Harold E.
,
Weiss, Robin A.
,
Friis, Robert R.
,
Levinson, Warren
,
Bishop, J. Michael
Description :
The effect of unlabeled cellular DNA upon the reassociation kinetics of labeled double-stranded DNA made by DNA polymerase from avian tumor viruses has been used to measure virus-specific nucleotide sequences in cells. Multiple copies of these sequences were found equally in normal chick cells, in c...
Repository :
Europe PubMed Central
Language(s) :
English
Synthesis of Viral DNA in the Cytoplasm of Duck Embryo Fibroblasts and in Enucleated Cells after Infection by Avian Sarcoma Virus
Author(s) :
Varmus, Harold E.
,
Guntaka, Ramareddy V.
,
Fan, Warner J. W.
,
Heasley, Suzanne
,
Bishop, J. Michael
Description :
Two lines of evidence indicate that synthesis of viral DNA occurs in the cytoplasm of duck embryo fibroblasts infected with avian sarcoma virus: (i) viral DNA is detected first in the cytoplasmic fraction of infected cells and subsequently in the nuclear fraction; and (ii) viral DNA is synthesized a...
Repository :
Europe PubMed Central
Language(s) :
English
Why PLoS Became a Publisher
Description :
Public Library of Science has grown from a grassroots movement to a nonprofit publisher, in order to catalyze change towards open-access publishing of the scientific literature
Repository :
Europe PubMed Central
Language(s) :
English
PLoS Medicine— A Medical Journal for the Internet Age
Description :
A message from the founders of the Public Library of Science
Repository :
Europe PubMed Central
Language(s) :
English
Deficiency of Pten accelerates mammary oncogenesis in MMTV-Wnt-1 transgenic mice
Author(s) :
Li Yi
,
Podsypanina Katrina
,
Liu Xiufan
,
Crane Allison
,
Tan Lee K
,
Parsons Ramon
,
Varmus Harold E
Description :
Abstract
Background
Germline mutations in the tumor suppressor
Repository :
DOAJ-Articles
Language(s) :
English
Genetic evidence for a role for Src family kinases in TNF family receptor signaling and cell survival
Author(s) :
Xing, Lianping
,
Venegas, Ana M.
,
Chen, Amy
,
Garrett-Beal, Lisa
,
Boyce, Brendan F.
,
Varmus, Harold E.
,
Schwartzberg, Pamela L.
Description :
Mutant src−/− mice have osteopetrosis resulting from defective osteoclasts, the cells that resorb bone. However, signaling pathways involving Src family members in osteoclasts remain unclear. We demonstrate that expression of a truncated Src molecule, Src251, lacking the kinase domain, induces osteo...
Repository :
Europe PubMed Central
Language(s) :
English
Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src−/− mutant mice
Author(s) :
Schwartzberg, Pamela L.
,
Xing, Lianping
,
Hoffmann, Oskar
,
Lowell, Clifford A.
,
Garrett, Lisa
,
Boyce, Brendan F.
Description :
The Src tyrosine kinase has been implicated in a wide variety of signal transduction pathways, yet despite the nearly ubiquitous expression of c-src, src−/− mice show only one major phenotype—osteopetrosis caused by an intrinsic defect in osteoclasts, the cells responsible for resorbing bone. To exp...
Repository :
Europe PubMed Central
Language(s) :
English