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author = "Varmus, Harold E."
<< < 1 2 3 4 5 > >>

Found 46 documents, displaying page 2 of 5

Evolution of somatic mutations in mammary tumors in transgenic mice is influenced by the inherited genotype

Author(s) : Podsypanina, Katrina , Li, Yi , Varmus, Harold E
Description :
Repository : Europe PubMed Central
Language(s) : English

PLoS Medicine- A Medical Journal for the Internet Age

Author(s) : Eisen Michael B , Brown Patrick O , Varmus Harold E
Description :
Repository : DOAJ-Articles
Language(s) : Undetermined

Why PLoS Became a Publisher

Author(s) : Brown Patrick O , Eisen Michael B , Varmus Harold E
Description :
Repository : DOAJ-Articles
Language(s) : Undetermined

Modeling mutations in the G1 arrest pathway in human gliomas: overexpression of CDK4 but not loss of INK4a–ARF induces hyperploidy in cultured mouse astrocytes

Author(s) : Holland, Eric C. , Hively, Wendy P. , Gallo, Vittorio , Varmus, Harold E.
Description : Nearly all human gliomas exhibit alterations in one of three genetic loci governing G1 arrest: INK4a–ARF, CDK4, or RB. To discern the roles of CDK4 amplification and INK4a–ARF loss in gliomagenesis, we compared the behavior of astrocytes lacking a functional INK4a–ARF locus with astrocytes overexpre...
Repository : Europe PubMed Central
Language(s) : English

Use of avian retroviral vectors to introduce transcriptional regulators into mammalian cells for analyses of tumor maintenance

Author(s) : Pao, William , Klimstra, David S. , Fisher, Galen H. , Varmus, Harold E.
Description : A key issue in cancer biology is whether genetic lesions involved in tumor initiation or progression are required for tumor maintenance. This question can be addressed with mouse models that conditionally express oncogenic transgenes, i.e., under the control of tetracycline (tet)-dependent trans...
Repository : Europe PubMed Central
Language(s) : English

Development of an Avian Leukosis-Sarcoma Virus Subgroup A Pseudotyped Lentiviral Vector

Author(s) : Lewis, Brian C. , Chinnasamy, Nachimuthu , Morgan, Richard A. , Varmus, Harold E.
Description : We are using avian leukosis-sarcoma virus (ALSV) vectors to generate mouse tumor models in transgenic mice expressing TVA, the receptor for subgroup A ALSV. Like other classical retroviruses, ALSV requires cell division to establish a provirus after infection of host cells. In contrast, lentiviral v...
Repository : Europe PubMed Central
Language(s) : English

env Gene of Chicken RNA Tumor Viruses: Extent of Conservation in Cellular and Viral Genomes

Author(s) : Fujita, Donald J. , Tal, Jacov , Varmus, Harold E. , Bishop, J. Michael
Description : The env gene of avian sarcoma-leukosis viruses codes for envelope glycoproteins that determine viral host range, antigenic specificity, and interference patterns. We used molecular hybridization to analyze the natural distribution and possible origins of the nucleotide sequences that encode env; our...
Repository : Europe PubMed Central
Language(s) : English

Membrane-anchored Plakoglobins Have Multiple Mechanisms of Action in Wnt Signaling

Author(s) : Klymkowsky, Michael W. , Williams, Bart O. , Barish, Grant D. , Varmus, Harold E. , Vourgourakis, Yanni E.
Description : In Wnt signaling, β-catenin and plakoglobin transduce signals to the nucleus through interactions with TCF-type transcription factors. However, when plakoglobin is artificially engineered to restrict it to the cytoplasm by fusion with the transmembrane domain of connexin (cnxPg), it efficiently indu...
Repository : Europe PubMed Central
Language(s) : English

Genetic Mapping of the Cloned Subgroup A Avian Sarcoma and Leukosis Virus Receptor Gene to the TVA Locus

Author(s) : Bates, Paul , Rong, Lijun , Varmus, Harold E. , Young, John A. T. , Crittenden, Lyman B.
Description : A chicken gene conferring susceptibility to subgroup A avian sarcoma and leukosis viruses (ASLV-A) was recently identified by a gene transfer strategy. Classical genetic approaches had previously identified a locus, TVA, that controls susceptibility to ASLV-A. Using restriction fragment length polym...
Repository : Europe PubMed Central
Language(s) : English

A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice

Author(s) : Holland, Eric C. , Hively, Wendy P. , DePinho, Ronald A. , Varmus, Harold E.
Description : The epidermal growth factor receptor (EGFR) gene is amplified or mutated in 30%–50% of human gliobastoma multiforme (GBM). These mutations are associated usually with deletions of the INK4a–ARF locus, which encodes two gene products (p16INK4a and p19ARF) involved in cell-cycle arrest and apoptosis. ...
Repository : Europe PubMed Central
Language(s) : English
<< < 1 2 3 4 5 > >>

Found 46 documents, displaying page 2 of 5