Results
author = "Talmage, D A"
Drosophila melanogaster H1 histone is phosphorylated stably.
Description :
Phosphorylation of histone H1 is developmentally regulated in Drosophila spp. It cannot be detected in preblastoderm embryos or polytene salivary gland cells, but in cellular blastoderm, postblastoderm embryo, and amitotic adult head nuclei, it occurs with a frequency of roughly 4 x 10(5) molecules ...
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Europe PubMed Central
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English
T cells can be cytotoxic without making interleukin 2: a model of separate pathways of induction.
Description :
The thoracic duct lymphocytes from rats previously injected with ultraviolet-light-irradiated allogeneic lymphocytes were grown for 4 days with alloantigen, with or without Con A-induced lymphokine factors, and then for 3 days with the lymphokines alone. They were then tested for their cytoxicity an...
Repository :
Europe PubMed Central
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English
Enhancement of the primary cytotoxic response to membrane by a lymphokine costimulator.
Description :
The primary and secondary cytotoxic T cell responses of C57Bl/6 (H-2b) mouse spleen cells to P-815 membrane fragments (H-2d) were examined. The primary response required the addition of a supernatant from mitogen-stimulated spleen cells, or costimulator, to the culture medium. Costimulator had littl...
Repository :
Europe PubMed Central
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English
Synergistic activation of simian immunodeficiency virus and human immunodeficiency virus type 1 transcription by retinoic acid and phorbol ester through an NF-kappa B-independent mechanism.
Description :
The activation of human immunodeficiency virus type 1 (HIV-1) expression in latently infected cells by exogenous agents is believed to be important in the progression of AIDS. Most factors that are known to activate HIV-1 gene expression increase the binding of NF-kappa B or NF-kappa B-like transcri...
Repository :
Europe PubMed Central
Language(s) :
English
Polyomavirus middle T antigen induces ribosomal protein S6 phosphorylation through pp60c-src-dependent and -independent pathways.
Description :
Phosphorylation of ribosomal protein S6 is elevated in polyomavirus-infected cells. This elevation results only in part from activation of S6 kinase activity. These effects appear to reflect independent activities of wild-type middle T antigen. Hr-t mutant NG59, encoding a defective middle T protein...
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Europe PubMed Central
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English
Rejection of stable cultured allografts by active or passive (adoptive) immunization.
Description :
Injection of live lymphoid cells of donor strain or immune cells of recipient strain resulted in rejection of previously stable cultured mouse thyroid allografts. The results are interpreted to indicate that a cultured graft is relatively ineffective in activating recipient lymphocytes but is capabl...
Repository :
Europe PubMed Central
Language(s) :
English
Macrophage activation: dissociation of cytotoxic activity from Ia-A antigen expression.
Description :
Peritoneal macrophages were obtained from DBA/2 mice that were untreated or after the injection of bacillus Calmette-Guerin (BCG), thioglycollate broth, proteose-peptone broth, or gamma-irradiated P-815 tumor cells. These macrophages were "activated" to become cytotoxic for a fibroblast cell line (L...
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Europe PubMed Central
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English
Immunosuppression by a mouse tumor resembles antigenic competition.
Description :
The intraperitoneal injection of gamma-radiated, UV-radiated, or unradiated P-815 tumor cells into syngeneic or allogeneic mice suppressed the immune response to a subsequent intraperitoneal injection of sheep erythrocytes in a manner similar to the suppression caused by the injection of manner simi...
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Europe PubMed Central
Language(s) :
English
Dimethyl sulfoxide prevents DNA nicking mediated by ionizing radiation or iron/hydrogen peroxide-generated hydroxyl radical.
Description :
Eighty percent of the single-strand DNA breaks induced by gamma-irradiation were prevented by the hydroxyl radical (.OH) scavenger dimethyl sulfoxide (Me2SO); CH4 was generated in the process as a product of the interaction of .OH and Me2SO. In contrast, Me2SO completely blocked DNA nicking by an ir...
Repository :
Europe PubMed Central
Language(s) :
English
Activation of cytotoxic T cells by nonstimulating tumor cells and spleen cell factor(s).
Description :
The ability of three cultured mouse tumor lines to stimulate a cytotoxic response in 5-day cultures of allogeneic lymph node cells was studied with a 51Cr release assay. Two lines of mesenchymal origin, P815 and EL-4, were found to be highly stimulatory, whereas the third cell line, CaD2, a mammary ...
Repository :
Europe PubMed Central
Language(s) :
English