Results
author = "Struman, Ingrid"
Sprouty1, a new target of the angiostatic agent 16K prolactin, negatively regulates angiogenesis
Author(s) :
Sabatel, Céline
,
Cornet, Anne
,
Tabruyn, Sébastien
,
Malvaux, Ludovic
,
Castermans, Karolien
,
Martial, Joseph
,
Struman, Ingrid
Description :
BACKGROUND:Disorganized angiogenesis is associated with several pathologies, including cancer. The identification of new genes that control tumor neovascularization can provide novel insights for future anti-cancer therapies. Sprouty1 (SPRY1), an inhibitor of the MAPK pathway, might be one of these ...
Repository :
ORBi (University of Liège)
Language(s) :
English
Sprouty1, a new target of the angiostatic agent 16K prolactin, negatively regulates angiogenesis
Author(s) :
Sabatel, Céline
,
Cornet, Anne M
,
Tabruyn, Sébastien P
,
Malvaux, Ludovic
,
Castermans, Karolien
,
Martial, Joseph A
Description :
Repository :
Europe PubMed Central
Language(s) :
English
The Antiangiogenic 16K Prolactin Impairs Functional Tumor Neovascularization by Inhibiting Vessel Maturation
Author(s) :
Nguyen, Ngoc-Quynh-Nhu
,
Castermans, Karolien
,
Berndt, Sarah
,
Herkenne, Stéphanie
,
Tabruyn, Sébastien
,
Blacher, Silvia
Description :
Background: Angiogenesis, the formation of new blood vessels from existing vasculature, plays an essential role in tumor growth, invasion, and metastasis. 16K hPRL, the antiangiogenic 16-kDa N-terminal fragment of human prolactin was shown to prevent tumor growth and metastasis by modifying tumor ve...
Repository :
ORBi (University of Liège)
Language(s) :
English
Inhibition of tumor growth and metastasis establishment by adenovirus-mediated gene transfer delivery of the antiangiogenic factor 16K hPRL
Author(s) :
Nguyen, Ngoc-Quynh-Nhu
,
Cornet, Anne
,
Blacher, Silvia
,
Tabruyn, Sébastien
,
Foidart, Jean-Michel
,
Noël, Agnès
,
Martial, Joseph
Description :
Tumor metastases, the most fearsome aspect of cancer, are generally resistant to conventional therapies. Angiogenesis is a crucial aspect of tumor growth and metastatic dissemination. Antiangiogenic therapy, therefore, holds potential as an attractive strategy for inhibiting metastasis development. ...
Repository :
ORBi (University of Liège)
Language(s) :
English
The antiangiogenic factor 16K human prolactin induces caspase-dependent apoptosis by a mechanism that requires activation of nuclear factor-kappa B
Author(s) :
Tabruyn, Sébastien
,
Sorlet, C. M.
,
Rentier-Delrue, Françoise
,
Bours, Vincent
,
Weiner, R. I.
,
Martial, Joseph
,
Struman, Ingrid
Description :
We have previously shown that the 16-kDa N-terminal fragment of human prolactin (16K hPRL) has antiangiogenic properties, including the ability to induce apoptosis in vascular endothelial cells. Here, we examined whether the nuclear factor-kappaB (NF-kappaB) signaling pathway was involved in mediati...
Repository :
ORBi (University of Liège)
Language(s) :
English
Zebrafish Sox7 and Sox18 function together to control arterial-venous identity
Author(s) :
Pendeville-Samain, Hélène
,
Winandy, Marie
,
Manfroid, Isabelle
,
Nivelles, Olivier
,
Motte, Patrick
,
Pasque, V.
,
Peers, Bernard
Description :
Sox7 and Sox18 are members of the F-subgroup of Sox transcription factors family and are mostly expressed in endothelial compartments. In humans, dominant mutations in Sox18 are the underlying cause of the severe hypotrichosis-lymphedema-telangiectasia disorder characterized by vascular defects. How...
Repository :
ORBi (University of Liège)
Language(s) :
English
Recovery from postpartum cardiomyopathy in 2 patients by blocking prolactin release with bromocriptine
Author(s) :
Hilfiker-Kleiner, D.
,
Meyer, G. P.
,
Schieffer, E.
,
Goldmann, B.
,
Podewski, E.
,
Struman, Ingrid
,
Fischer, P.
,
Drexler, H.
Description :
Repository :
ORBi (University of Liège)
Language(s) :
English
Dre-miR-2188 Targets Nrp2a and Mediates Proper Intersegmental Vessel Development in Zebrafish Embryos.
Author(s) :
Soares, Ana R.
,
Reverendo, Marisa
,
Pereira, Patricia M.
,
Nivelles, Olivier
,
Pendeville, Helene
,
Bezerra, Ana Rita
Description :
BACKGROUND: MicroRNAs (miRNAs) are a class of small RNAs that are implicated in the control of eukaryotic gene expression by binding to the 3'UTR of target mRNAs. Several algorithms have been developed for miRNA target prediction however, experimental validation is still essential for the correct id...
Repository :
ORBi (University of Liège)
Language(s) :
English
The angiostatic 16K human prolactin overcomes endothelial cell anergy and promotes leukocyte infiltration via nuclear factor-kappaB activation
Author(s) :
Tabruyn, Sébastien
,
Sabatel, Céline
,
Nguyen, Ngoc-Quynh-Nhu
,
Verhaeghe
,
Castermans, Karolien
,
Malvaux, Ludovic
Description :
The 16-kDa N-terminal fragment of human prolactin (16K hPRL) is a potent angiostatic factor that inhibits tumor growth in mouse models. Using microarray experiments, we have dissected how the endothelial-cell genome responds to 16K hPRL treatment. We found 216 genes that show regulation by 16K hPRL,...
Repository :
ORBi (University of Liège)
Language(s) :
English
Evaluation of bromocriptine in the treatment of acute severe peripartum cardiomyopathy: a proof-of-concept pilot study.
Author(s) :
Sliwa, Karen
,
Blauwet, Lori
,
Tibazarwa, Kemi
,
Libhaber, Elena
,
Smedema, Jan*-Peter
,
Becker, Anthony
,
McMurray, John
Description :
BACKGROUND: Peripartum cardiomyopathy (PPCM) is a potentially life-threatening heart disease that occurs in previously healthy women. We identified prolactin, mainly its 16-kDa angiostatic and proapoptotic form, as a key factor in PPCM pathophysiology. Previous reports suggest that bromocriptine may...
Repository :
ORBi (University of Liège)
Language(s) :
English