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author = "Stoeckli, Esther T."
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Found 5 documents, displaying page 1 of 1

Cell type specific, traceable gene silencing for functional gene analysis during vertebrate neural development

Author(s) : Wilson, Nicole H. , Stoeckli, Esther T.
Description : Many genes have several, sometimes divergent functions during development. Therefore, timing of gene knockdown for functional analysis during development has to be done with precise temporal control, as loss of a gene's function at early stages prevents its analysis later in development. RNAi, in co...
Repository : Europe PubMed Central
Language(s) : English

Evidence for a Role of srGAP3 in the Positioning of Commissural Axons within the Ventrolateral Funiculus of the Mouse Spinal Cord

Author(s) : Bacon, Claire , Endris, Volker , Andermatt, Irwin , Niederkofler, Vera , Waltereit, Robert , Bartsch, Dusan , Stoeckli, Esther T.
Description : Slit-Robo signaling guides commissural axons away from the floor-plate of the spinal cord and into the longitudinal axis after crossing the midline. In this study we have evaluated the role of the Slit-Robo GTPase activating protein 3 (srGAP3) in commissural axon guidance using a knockout (KO) mouse...
Repository : Europe PubMed Central
Language(s) : English

The transcription factors Nkx2.2 and Nkx2.9 play a novel role in floor plate development and commissural axon guidance

Author(s) : Holz, Andreas , Kollmus, Heike , Ryge, Jesper , Niederkofler, Vera , Dias, Jose , Ericson, Johan , Stoeckli, Esther T.
Description : The transcription factors Nkx2.2 and Nkx2.9 have been proposed to execute partially overlapping functions in neuronal patterning of the ventral spinal cord in response to graded sonic hedgehog signaling. The present report shows that in mice lacking both Nkx2 proteins, the presumptive progenitor cel...
Repository : Europe PubMed Central
Language(s) : English

Hereditary Sensory Neuropathy Type 1 Is Caused by the Accumulation of Two Neurotoxic Sphingolipids*♦

Author(s) : Penno, Anke , Reilly, Mary M. , Houlden, Henry , Laurá, Matilde , Rentsch, Katharina , Niederkofler, Vera , Stoeckli, Esther T.
Description : HSAN1 is an inherited neuropathy found to be associated with several missense mutations in the SPTLC1 subunit of serine palmitoyltransferase (SPT). SPT catalyzes the condensation of serine and palmitoyl-CoA, the initial step in the de novo synthesis of sphingolipids. Here we show that the HSAN1 muta...
Repository : Europe PubMed Central
Language(s) : English

A Direct Interaction of Axonin-1 with Ngcam-Related Cell Adhesion Molecule (Nrcam) Results in Guidance, but Not Growth of Commissural Axons

Author(s) : Fitzli, Dora , Stoeckli, Esther T. , Kunz, Stefan , Siribour, Kingsley , Rader, Christoph , Kunz, Beat , Kozlov, Serguei V.
Description : An interaction of growth cone axonin-1 with the floor-plate NgCAM-related cell adhesion molecule (NrCAM) was shown to play a crucial role in commissural axon guidance across the midline of the spinal cord. We now provide evidence that axonin-1 mediates a guidance signal without promoting axon elonga...
Repository : Europe PubMed Central
Language(s) : English
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Found 5 documents, displaying page 1 of 1