Results
author = "Song, HL"
ESR1/SYNE1 Polymorphism and Invasive Epithelial Ovarian Cancer Risk: An Ovarian Cancer Association Consortium Study
Author(s) :
Doherty, JA
,
Rossing, MA
,
Cushing-Haugen, KL
,
Chen, C
,
Van Den Berg, DJ
,
Wu, AH
,
Pike, MC
,
Ness, RB
,
Moysich, K
,
Chenevix-Trench, G
Description :
We genotyped 13 single nucleotide polymorphisms (SNPs) in the estrogen receptor alpha gene (ESR1) region in three population-based case-control studies of epithelial ovarian cancer conducted in the United States, comprising a total of 1,128 and 1,866 non-Hispanic white invasive cases and controls, r...
Repository :
UCL Eprints
Language(s) :
Undetermined
Polymorphism in the GALNT1 Gene and Epithelial Ovarian Cancer in Non-Hispanic White Women: The Ovarian Cancer Association Consortium
Author(s) :
Phelan, CM
,
Tsai, YY
,
Goode, EL
,
Vierkant, RA
,
Fridley, BL
,
Beesley, J
,
Chen, XQ
,
Webb, PM
,
Chanock, S
,
Cramer, DW
,
Moysich, K
Description :
Aberrant glycosylation is a well-described hallmark of cancer. In a previous ovarian cancer case control study that examined polymorphisms in 26 glycosylation-associated genes, we found strong statistical evidence (P = 0.00017) that women who inherited two copies of a single-nucleotide polymorphism ...
Repository :
UCL Eprints
Language(s) :
Undetermined
Polymorphism in the IL18 Gene and Epithelial Ovarian Cancer in Non-Hispanic White Women
Author(s) :
Palmieri, RT
,
Wilson, MA
,
Iversen, ES
,
Clyde, MA
,
Calingaert, B
,
Moorman, PG
,
Poole, C
,
Anderson, AR
,
Anderson, S
,
Anton-Culver, H
Description :
Over 22,000 cases of ovarian cancer were diagnosed in 2007 in the United States, but only a fraction of them can be attributed to mutations in highly penetrant genes such as BRCA1. To determine whether low-penetrance genetic variants contribute to ovarian cancer risk, we genotyped 1,536 single nucle...
Repository :
UCL Eprints
Language(s) :
Undetermined
Single Nucleotide Polymorphisms in the TP53 Region and Susceptibility to Invasive Epithelial Ovarian Cancer
Author(s) :
Schildkraut, JM
,
Goode, EL
,
Clyde, MA
,
Iversen, ES
,
Moorman, PG
,
Berchuck, A
,
Marks, JR
,
Lissowska, J
,
Brinton, L
,
Peplonska, B
Description :
The p53 protein is critical for multiple cellular functions including cell growth and DNA repair. We assessed whether polymorphisms in the region encoding TP53 were associated with risk of invasive ovarian cancer. The study population includes a total of 5,206 invasive ovarian cancer cases (2,829 of...
Repository :
UCL Eprints
Language(s) :
Undetermined
Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study
Author(s) :
Song, HL
,
Ramus, SJ
,
Kjaer, SK
,
DiCioccio, RA
,
Chenevix-Trench, G
,
Pearce, CL
,
Hogdall, E
,
Whittemore, AS
,
McGuire, V
Description :
Because both ovarian and breast cancer are hormone-related and are known to have some predisposition genes in common, we evaluated 11 of the most significant hits (six with confirmed associations with breast cancer) from the breast cancer genome-wide association study for association with invasive o...
Repository :
UCL Eprints
Language(s) :
Undetermined
Genetic Variation in TYMS in the One-Carbon Transfer Pathway Is Associated with Ovarian Carcinoma Types in the Ovarian Cancer Association Consortium
Author(s) :
Kelemen, LE
,
Goodman, MT
,
McGuire, V
,
Rossing, MA
,
Webb, PM
,
Kobel, M
,
Anton-Culver, H
,
Beesley, J
,
Berchuck, A
,
Brar, S
Description :
Background: We previously reported the risks of ovarian carcinoma for common polymorphisms in one-carbon transfer genes. We sought to replicate associations for DPYD rs1801265, DNMT3A rs13420827, MTHFD1 rs1950902, MTHFS rs17284990, and TYMS rs495139 with risk of ovarian carcinoma overall and to use ...
Repository :
UCL Eprints
Language(s) :
Undetermined
Evaluation of Candidate Stromal Epithelial Cross-Talk Genes Identifies Association between Risk of Serous Ovarian Cancer and TERT, a Cancer Susceptibility "Hot-Spot''
Author(s) :
Johnatty, SE
,
Beesley, J
,
Chen, XQ
,
Macgregor, S
,
Duffy, DL
,
Spurdle, AB
,
deFazio, A
,
Gava, N
,
Webb, PM
,
Rossing, MA
,
Doherty, JA
Description :
We hypothesized that variants in genes expressed as a consequence of interactions between ovarian cancer cells and the host micro-environment could contribute to cancer susceptibility. We therefore used a two-stage approach to evaluate common single nucleotide polymorphisms (SNPs) in 173 genes invol...
Repository :
UCL Eprints
Language(s) :
Undetermined
Common alleles in candidate susceptibility genes associated with risk and development of epithelial ovarian cancer
Author(s) :
Notaridou, M
,
Quaye, L
,
Dafou, D
,
Jones, C
,
Song, HL
,
Hogdall, E
,
Kjaer, SK
,
Christensen, L
,
Hogdall, C
,
Blaakaer, J
,
McGuire, V
Description :
Common germline genetic variation in the population is associated with susceptibility to epithelial ovarian cancer. Microcell-mediated chromosome transfer and expression microarray analysis identified nine genes associated with functional suppression of tumorogenicity in ovarian cancer cell lines; A...
Repository :
UCL Eprints
Language(s) :
Undetermined
A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2
Author(s) :
Song, HL
,
Ramus, SJ
,
Tyrer, J
,
Bolton, KL
,
Gentry-Maharaj, A
,
Wozniak, E
,
Anton-Culver, H
,
Chang-Claude, J
,
Cramer, DW
Description :
Epithelial ovarian cancer has a major heritable component, but the known susceptibility genes explain less than half the excess familial risk(1). We performed a genome-wide association study (GWAS) to identify common ovarian cancer susceptibility alleles. We evaluated 507,094 SNPs genotyped in 1,817...
Repository :
UCL Eprints
Language(s) :
Undetermined
The Role of KRAS rs61764370 in Invasive Epithelial Ovarian Cancer: Implications for Clinical Testing
Author(s) :
Pharoah, PDP
,
Palmieri, RT
,
Ramus, SJ
,
Gayther, SA
,
Andrulis, IL
,
Anton-Culver, H
,
Antonenkova, N
,
Antoniou, AC
,
Goldgar, D
Description :
Purpose: An assay for the single-nucleotide polymorphism (SNP), rs61764370, has recently been commercially marketed as a clinical test to aid ovarian cancer risk evaluation in women with family histories of the disease. rs67164370 is in a 3'-UTR miRNA binding site of the KRAS oncogene and is a candi...
Repository :
UCL Eprints
Language(s) :
Undetermined