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author = "Shevelev, Igor"
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Found 15 documents, displaying page 2 of 2

The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase β and increases its DNA substrate utilisation efficiency: implications for DNA repair

Author(s) : Toueille, Magali , El-Andaloussi, Nazim , Frouin, Isabelle , Freire, Raimundo , Funk, Dorothee , Shevelev, Igor , Friedrich-Heineken, Erica
Description : In eukaryotic cells, checkpoints are activated in response to DNA damage. This requires the action of DNA damage sensors such as the Rad family proteins. The three human proteins Rad9, Rad1 and Hus1 form a heterotrimeric complex (called the 9-1-1 complex) that is recruited onto DNA upon damage. DNA ...
Repository : Europe PubMed Central
Language(s) : English

Physical Interaction of RECQ5 Helicase with RAD51 Facilitates Its Anti-recombinase Activity*

Author(s) : Schwendener, Sybille , Raynard, Steven , Paliwal, Shreya , Cheng, Anita , Kanagaraj, Radhakrishnan , Shevelev, Igor
Description : Homologous recombination (HR) provides an efficient mechanism for error-free repair of DNA double-strand breaks (DSBs). However, HR can be also harmful as inappropriate or untimely HR events can give rise to lethal recombination intermediates and chromosome rearrangements. A critical step of HR is t...
Repository : Europe PubMed Central
Language(s) : English

RECQ5 helicase associates with the C-terminal repeat domain of RNA polymerase II during productive elongation phase of transcription

Author(s) : Kanagaraj, Radhakrishnan , Huehn, Daniela , MacKellar, April , Menigatti, Mirco , Zheng, Lu , Urban, Vaclav , Shevelev, Igor
Description : It is known that transcription can induce DNA recombination, thus compromising genomic stability. RECQ5 DNA helicase promotes genomic stability by regulating homologous recombination. Recent studies have shown that RECQ5 forms a stable complex with RNA polymerase II (RNAPII) in human cells, but the ...
Repository : Europe PubMed Central
Language(s) : English

The human RecQ helicases BLM and RECQL4 cooperate to preserve genome stability

Author(s) : Singh, Dharmendra Kumar , Popuri, Venkateswarlu , Kulikowicz, Tomasz , Shevelev, Igor , Ghosh, Avik K. , Ramamoorthy, Mahesh
Description : Bacteria and yeast possess one RecQ helicase homolog whereas humans contain five RecQ helicases, all of which are important in preserving genome stability. Three of these, BLM, WRN and RECQL4, are mutated in human diseases manifesting in premature aging and cancer. We are interested in determining t...
Repository : Europe PubMed Central
Language(s) : English

In Vitro Gap-directed Translesion DNA Synthesis of an Abasic Site Involving Human DNA Polymerases ϵ, λ, and β*

Author(s) : Villani, Giuseppe , Hubscher, Ulrich , Gironis, Nadege , Parkkinen, Sinikka , Pospiech, Helmut , Shevelev, Igor , di Cicco, Giulia
Description : DNA polymerase (pol) ϵ is thought to be the leading strand replicase in eukaryotes, whereas pols λ and β are believed to be mainly involved in re-synthesis steps of DNA repair. DNA elongation by the human pol ϵ is halted by an abasic site (apurinic/apyrimidinic (AP) site). In this study, we present ...
Repository : Europe PubMed Central
Language(s) : English
<< < 1 2

Found 15 documents, displaying page 2 of 2