Results
author = "Shaw, Peter"
Phylogeny, phylogeography, phylobetadiversity and the molecular analysis of biological communities
Description :
There has been much recent interest and progress in the characterization of community structure and community assembly processes through the application of phylogenetic methods. To date most focus has been on groups of taxa for which some relevant detail of their ecology is known, for which communit...
Repository :
Europe PubMed Central
Language(s) :
English
Transcription Sites Are Not Correlated with Chromosome Territories in Wheat Nuclei
Description :
We have determined the relationship between overall nuclear architecture, chromosome territories, and transcription sites within the nucleus, using three-dimensional confocal microscopy of well preserved tissue sections of wheat roots. Chromosome territories were visualized by GISH using rye genomi...
Repository :
Europe PubMed Central
Language(s) :
English
Colorectal cancers with microsatellite instability display mRNA expression signatures characteristic of increased immunogenicity
Author(s) :
Banerjea Ayan
,
Ahmed Shafi
,
Hands Rebecca E
,
Huang Fei
,
Han Xia
,
Shaw Peter M
,
Feakins Roger
,
Bustin Stephen A
,
Dorudi Sina
Description :
Abstract
Background
Colorectal cancers displaying high-degree microsatellite instability (MSI-H) have an improved prognosis compared to microsatellite stable (MSS) cancers. The observation of pronounced lymphocytic infiltrates suggests that MSI-H cancers are inherently more immunoge...
Repository :
DOAJ-Articles
Language(s) :
English
Interplay of ribosomal DNA Loci in nucleolar dominance: dominant NORs are up-regulated by chromatin dynamics in the wheat-rye system
Author(s) :
Silva, Manuela
,
Viegas, Wanda
,
Pereira, H. Sofia
,
Bento, Miguel
,
Santos, Ana Paula
,
Shaw, Peter
,
Delgado, Margarida
Description :
Background: Chromatin organizational and topological plasticity, and its functions in gene expression regulation, have
been strongly revealed by the analysis of nucleolar dominance in hybrids and polyploids where one parental set of
ribosomal RNA (rDNA) genes that are clustered in nucleolar organizi...
Repository :
Repositório da Universidade Técnica de Lisboa
Language(s) :
English
KOJAK encodes a cellulose synthase-like protein required for root hair cell morphogenesis in Arabidopsis
Author(s) :
Favery, Bruno
,
Ryan, Eoin
,
Foreman, Julia
,
Linstead, Paul
,
Boudonck, Kurt
,
Steer, Martin
,
Shaw, Peter
,
Dolan, Liam
Description :
The cell wall is an important determinant of plant cell form. Here we define a class of Arabidopsis root hair mutants with defective cell walls. Plants homozygous for kojak (kjk) mutations initiate root hairs that rupture at their tip soon after initiation. The KJK gene was isolated by positional cl...
Repository :
Europe PubMed Central
Language(s) :
English
Interplay of Ribosomal DNA Loci in Nucleolar Dominance: Dominant NORs Are Up-Regulated by Chromatin Dynamics in the Wheat-Rye System
Author(s) :
Silva, Manuela
,
Pereira, H. Sofia
,
Bento, Miguel
,
Santos, Ana Paula
,
Shaw, Peter
,
Delgado, Margarida
,
Neves, Nuno
Description :
Repository :
Europe PubMed Central
Language(s) :
English
The Structural Determinants of Macrolide-Actin Binding: In Silico Insights
Author(s) :
Melville, James L.
,
Moal, Iain H.
,
Baker-Glenn, Charles
,
Shaw, Peter E.
,
Pattenden, Gerald
,
Hirst, Jonathan D.
Description :
By the use of x-ray structures and flexible docking, we have developed the first in silico ligand-based view of the structural determinants of the binding of small molecule mimics of gelsolin, natural products bound to actin. Our technique highlights those residues on the actin binding site forming ...
Repository :
Europe PubMed Central
Language(s) :
English
Cyclic AMP-Dependent Kinase Regulates Raf-1 Kinase Mainly by Phosphorylation of Serine 259
Author(s) :
Dhillon, Amardeep S.
,
Pollock, Claire
,
Steen, Helge
,
Shaw, Peter E.
,
Mischak, Harald
,
Kolch, Walter
Description :
The Raf-1 kinase activates the ERK (extracellular-signal-regulated kinase) pathway. The cyclic AMP (cAMP)-dependent protein kinase (PKA) can inhibit Raf-1 by direct phosphorylation. We have mapped all cAMP-induced phosphorylation sites in Raf-1, showing that serines 43, 259, and 621 are phosphorylat...
Repository :
Europe PubMed Central
Language(s) :
English
DNA-bound transcription factor complexes analysed by mass-spectrometry: binding of novel proteins to the human c-fos SRE and related sequences
Author(s) :
Drewett, Victoria
,
Molina, Henrik
,
Millar, Alan
,
Muller, Silke
,
Hesler, Friedrich
von
,
Shaw, Peter E.
Description :
Transcription factors control eukaryotic polymerase II function
by influencing the recruitment of multiprotein complexes to promoters
and their subsequent integrated function. The complexity of the
functional ‘transcriptosome’ has necessitated
biochemical fractionation and subsequent protein seq...
Repository :
Europe PubMed Central
Language(s) :
English
Amphotericin B in Children with Malignant Disease: a Comparison of the Toxicities and Pharmacokinetics of Amphotericin B Administered in Dextrose versus Lipid Emulsion
Author(s) :
Nath, Christa E.
,
Shaw, Peter J.
,
Gunning, Robyn
,
McLachlan, Andrew J.
,
Earl, John W.
Description :
In a prospective, randomized clinical trial, the toxicity of 1 mg of amphotericin B (AmB) per kg of body weight per day infused in 5% dextrose was compared with that of AmB infused in lipid emulsion in children with malignant disease. In an analysis of 82 children who received a full course of 6 day...
Repository :
Europe PubMed Central
Language(s) :
English