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author = "Sette, Alessandro"

Found 140 documents, displaying page 2 of 14

Design and utilization of epitope-based databases and predictive tools

Description : In the last decade, significant progress has been made in expanding the scope and depth of publicly available immunological databases and online analysis resources, which have become an integral part of the repertoire of tools available to the scientific community for basic and applied research. Her...
Repository : Europe PubMed Central
Language(s) : English

Meta-analysis of All Immune Epitope Data in the Flavivirus Genus: Inventory of Current Immune Epitope Data Status in the Context of Virus Immunity and Immunopathology

Description : A meta-analysis was performed in order to inventory the immune epitope data related to viruses in the genus Flavivirus. Nearly 2000 epitopes were captured from over 130 individual Flavivirus-related references identified from PubMed and reported as of September 2009. This report includes all epitope...
Repository : Europe PubMed Central
Language(s) : English

Targeting OX40 Promotes Lung-Resident Memory CD8 T Cell Populations That Protect against Respiratory Poxvirus Infection▿

Description : One goal of vaccination is to promote development of mucosal effector cells that can immediately respond to peripheral infection. This is especially important for protection against viruses that enter the host through the respiratory tract. We show that targeting the OX40 costimulatory receptor (CD1...
Repository : Europe PubMed Central
Language(s) : English

Positional Bias of MHC Class I Restricted T-Cell Epitopes in Viral Antigens Is Likely due to a Bias in Conservation

Description : The immune system rapidly responds to intracellular infections by detecting MHC class I restricted T-cell epitopes presented on infected cells. It was originally thought that viral peptides are liberated during constitutive protein turnover, but this conflicts with the observation that viral epitope...
Repository : Europe PubMed Central
Language(s) : English

Predicting population coverage of T-cell epitope-based diagnostics and vaccines

Description :

Abstract

Background

T cells recognize a complex between a specific major histocompatibility complex (MHC) molecule and a particular pathogen-derived epitope. A given epitope will elicit a response only in individuals that express an MHC molecule capable of binding that particular ep...

Repository : DOAJ-Articles
Language(s) : English

Of mice and humans: how good are HLA transgenic mice as a model of human immune responses?

Description :

Abstract

Background

Previous studies have defined vaccinia virus (VACV)-derived T cell epitopes in VACV-infected human leukocyte antigen-A*0201 (HLA-A2.1) transgenic (Tg) mice and A2.1-positive human Dryvax vaccinees. A total of 14 epitopes were detected in humans and 16 epitopes in...

Repository : DOAJ-Articles
Language(s) : English

Peptide binding predictions for HLA DR, DP and DQ molecules

Description :

Abstract

Background

MHC class II binding predictions are widely used to identify epitope candidates in infectious agents, allergens, cancer and autoantigens. The vast majority of prediction algorithms for human MHC class II to date have targeted HLA molecules encoded in the DR locus...

Repository : DOAJ-Articles
Language(s) : English

Found 140 documents, displaying page 2 of 14