Results
author = "Sette, Alessandro"
The Immune Epitope Database and Analysis Resource: From Vision to Blueprint
Author(s) :
Peters, Bjoern
,
Sidney, John
,
Bourne, Phil
,
Bui, Huynh-Hoa
,
Buus, Soeren
,
Doh, Grace
,
Fleri, Ward
,
Kronenberg, Mitch
Description :
A planned repository of immune epitope data with associated analysis tools should be a boon to vaccine development
Repository :
Europe PubMed Central
Language(s) :
English
HLA class I-restricted responses to vaccinia recognize a broad array of proteins mainly involved in virulence and viral gene regulation
Author(s) :
Oseroff, Carla
,
Kos, Ferdynand
,
Bui, Huynh-Hoa
,
Peters, Bjoern
,
Pasquetto, Valerie
,
Glenn, Jean
,
Palmore, Tara
,
Sidney, John
Description :
We have analyzed by ex vivo ELISPOT the anti-vaccinia cytotoxic T lymphocyte responses of peripheral blood mononuclear cells from humans vaccinated with Dryvax vaccine. More than 6,000 peptides from 258 putative vaccinia ORFs predicted to bind the common molecules of the HLA A1, A2, A3, A24, B7, and...
Repository :
Europe PubMed Central
Language(s) :
English
In Silico Prediction of Peptides Binding to Multiple HLA-DR Molecules Accurately Identifies Immunodominant Epitopes from gp43 of Paracoccidioides brasiliensis Frequently Recognized in Primary Peripheral Blood Mononuclear Cell Responses from Sensitized Individuals
Author(s) :
Iwai, Leo Kei
,
Yoshida, Márcia
,
Sidney, John
,
Shikanai-Yasuda, Maria Aparecida
,
Goldberg, Anna Carla
,
Juliano, Maria Aparecida
Description :
One of the major drawbacks limiting the use of synthetic peptide vaccines in genetically distinct populations is the fact that different epitopes are recognized by T cells from individuals displaying distinct major histocompatibility complex molecules. Immunization of mice with peptide (181-195) fro...
Repository :
Europe PubMed Central
Language(s) :
English
A Community Resource Benchmarking Predictions of Peptide Binding to MHC-I Molecules
Author(s) :
Peters, Bjoern
,
Bui, Huynh-Hoa
,
Frankild, Sune
,
Nielsen, Morten
,
Lundegaard, Claus
,
Kostem, Emrah
,
Basch, Derek
,
Lamberth, Kasper
Description :
Recognition of peptides bound to major histocompatibility complex (MHC) class I molecules by T lymphocytes is an essential part of immune surveillance. Each MHC allele has a characteristic peptide binding preference, which can be captured in prediction algorithms, allowing for the rapid scan of enti...
Repository :
Europe PubMed Central
Language(s) :
English
CD8+ T-Cell Responses to Trypanosoma cruzi Are Highly Focused on Strain-Variant trans-Sialidase Epitopes
Author(s) :
Martin, Diana L
,
Weatherly, D. Brent
,
Laucella, Susana A
,
Cabinian, Melissa A
,
Crim, Matthew T
,
Sullivan, Susan
Description :
CD8+ T cells are crucial for control of a number of medically important protozoan parasites, including Trypanosoma cruzi, the agent of human Chagas disease. Yet, in contrast to the wealth of information from viral and bacterial infections, little is known about the antigen specificity or the general...
Repository :
Europe PubMed Central
Language(s) :
English
Identification of Protective Lassa Virus Epitopes That Are Restricted by HLA-A2
Author(s) :
Botten, Jason
,
Alexander, Jeff
,
Pasquetto, Valerie
,
Sidney, John
,
Barrowman, Polly
,
Ting, Joey
,
Peters, Bjoern
,
Southwood, Scott
Description :
Recovery from Lassa virus (LASV) infection usually precedes the appearance of neutralizing antibodies, indicating that cellular immunity plays a primary role in viral clearance. To date, the role of LASV-specific CD8+ T cells has not been evaluated in humans. To facilitate such studies, we utilized ...
Repository :
Europe PubMed Central
Language(s) :
English
Comprehensive Analysis of Human Immunodeficiency Virus Type 1-Specific CD4 Responses Reveals Marked Immunodominance of gag and nef and the Presence of Broadly Recognized Peptides
Author(s) :
Kaufmann, Daniel E.
,
Bailey, Paul M.
,
Sidney, John
,
Wagner, Bradford
,
Norris, Philip J.
,
Johnston, Mary N.
,
Cosimi, Lisa A.
Description :
Increasing evidence suggests that human immunodeficiency virus type 1 (HIV-1)-specific CD4 T-cell responses contribute to effective immune control of HIV-1 infection. However, the breadths and specificities of these responses have not been defined. We screened fresh CD8-depleted peripheral blood mon...
Repository :
Europe PubMed Central
Language(s) :
English
Identification of poxvirus CD8+ T cell determinants to enable rational design and characterization of smallpox vaccines
Author(s) :
Tscharke, David C.
,
Karupiah, Gunasegaran
,
Zhou, Jie
,
Palmore, Tara
,
Irvine, Kari R.
,
Haeryfar, S.M. Mansour
,
Williams, Shanicka
Description :
The large size of poxvirus genomes has stymied attempts to identify determinants recognized by CD8+ T cells and greatly impeded development of mouse smallpox vaccination models. Here, we use a vaccinia virus (VACV) expression library containing each of the predicted 258 open reading frames to identi...
Repository :
Europe PubMed Central
Language(s) :
English
Herpes simplex virus type 2 tegument proteins contain subdominant T-cell epitopes detectable in BALB/c mice after DNA immunization and infection
Author(s) :
Muller, William J.
,
Dong, Lichun
,
Vilalta, Adrian
,
Byrd, Benjamin
,
Wilhelm, Kai M.
,
McClurkan, Christopher L.
,
Margalith, Michal
Description :
Cytotoxic T cells are important in controlling herpes simplex virus type 2 (HSV-2) reactivation and peripheral lesion resolution. Humans latently infected with HSV-2 have cytotoxic T cells directed against epitopes present in tegument proteins. Studies in mice of immunity to HSV have commonly focuse...
Repository :
Europe PubMed Central
Language(s) :
English
Cellular immune response to cryptic epitopes during therapeutic gene transfer
Author(s) :
Li, Chengwen
,
Goudy, Kevin
,
Hirsch, Matt
,
Asokan, Aravind
,
Fan, Yun
,
Alexander, Jeff
,
Sun, Junjiang
,
Monahan, Paul
Description :
The immune response has been implicated as a critical factor in determining the success or failure of clinical gene therapy trials. Generally, such a response is elicited by the desired transgene product or, in some cases, the delivery system. In the current study, we report the previously uncharact...
Repository :
Europe PubMed Central
Language(s) :
English