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author = "Seeburg, P H"
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Found 42 documents, displaying page 1 of 5

A system for shotgun DNA sequencing.

Author(s) : Messing, J , Crea, R , Seeburg, P H
Description : A multipurpose cloning site has been introduced into the gene for beta-galactosidase (beta-D-galactosidegalactohydrolase, EC 3.21.23) on the single-stranded DNA phage M13mp2 (Gronenborn, B. and Messing, J., (1978) Nature 272, 375-377) with the use of synthetic DNA. The site contributes 14 additional...
Repository : Europe PubMed Central
Language(s) : English

gamma-Aminobutyric acid type A receptor point mutation increases the affinity of compounds for the benzodiazepine site.

Author(s) : Pritchett, D B , Seeburg, P H
Description : Recombinantly expressed gamma-aminobutyric acid type A (GABAA) receptors consisting of alpha 1, beta 2, and gamma 2 subunits contain a binding site for benzodiazepines that differs in its properties from that of alpha 3 beta 2 gamma 2 receptors. Amino acid substitutions between the GABAA receptor al...
Repository : Europe PubMed Central
Language(s) : English

Molecular basis for familial isolated growth hormone deficiency.

Author(s) : Phillips, J A , Hjelle, B L , Seeburg, P H , Zachmann, M
Description : Nuclear DNA from four individuals with familial isolated growth hormone (somatotropin) deficiency (IGHD) type A was studied by restriction endonuclease analysis. By using 32P-labeled human growth hormone (hGH) cDNA sequences as a probe, patterns seen after various digestions indicated that these ind...
Repository : Europe PubMed Central
Language(s) : English

The human growth hormone gene family: structure and evolution of the chromosomal locus.

Author(s) : Barsh, G S , Seeburg, P H , Gelinas, R E
Description : The structure of the human growth hormone gene cluster has been determined over a 78 kilobase region of DNA by the study of two overlapping cosmids. There are two growth hormone genes interspersed with three chorionic somatomammotropin genes, all in the same transcriptional orientation. One of the g...
Repository : Europe PubMed Central
Language(s) : English

Relative levels of methylation in human growth hormone and chorionic somatomammotropin genes in expressing and non-expressing tissues.

Author(s) : Hjelle, B L , Phillips, J A , Seeburg, P H
Description : It has been shown that the extent of methylation of cytosine in vertebrate DNA is inversely correlated with gene expression. We studied cytosine methylation in and around the homologous human growth hormone (GH) and chorionic somatomammotropin (CS) genes to determine if these genes are undermethylat...
Repository : Europe PubMed Central
Language(s) : English

Rapid construction in yeast of complex targeting vectors for gene manipulation in the mouse.

Author(s) : Storck, T , Krüth, U , Kolhekar, R , Sprengel, R , Seeburg, P H
Description : Targeting vectors for embryonic stem (ES) cells typically contain a mouse gene segment of >7 kb with the neo gene inserted for positive selection of the targeting event. More complex targeting vectors carry additional genetic elements (e.g. lacZ, loxP, point mutations). Here we use homologous recomb...
Repository : Europe PubMed Central
Language(s) : English

Isolation of the gene and hypothalamic cDNA for the common precursor of gonadotropin-releasing hormone and prolactin release-inhibiting factor in human and rat.

Author(s) : Adelman, J P , Mason, A J , Hayflick, J S , Seeburg, P H
Description : Cloned cDNAs encoding the precursor protein for gonadotropin-releasing hormone (Gn-RH) and prolactin release-inhibiting factor (PIF) were isolated from libraries derived from human and rat hypothalamic mRNA. Nucleotide sequence analyses predict precursor proteins of 92 amino acids for both species a...
Repository : Europe PubMed Central
Language(s) : English

Cloning and expression of cDNA for human diazepam binding inhibitor, a natural ligand of an allosteric regulatory site of the gamma-aminobutyric acid type A receptor.

Author(s) : Gray, P W , Glaister, D , Seeburg, P H , Guidotti, A , Costa, E
Description : Diazepam binding inhibitor (DBI) is a protein that displaces ligands bound to the beta-carboline/benzodiazepine recognition site, an allosteric modulatory site of the type A gamma-aminobutyric acid receptor complex. An incomplete rat cDNA clone coding for DBI was isolated. This rat sequence was util...
Repository : Europe PubMed Central
Language(s) : English

Regulation of growth hormone messenger RNA by thyroid and glucocorticoid hormones.

Author(s) : Martial, J A , Baxter, J D , Goodman, H M , Seeburg, P H
Description : Thyroid and glucocorticoid hormones stimulate growth hormone synthesis in cultured rat pituitary cells (GC). We have compared changes in growth hormone production and mRNA in these cells. Triiodothyronine (10 nM) and dexamethasone (1 micron) stimulated increases in growth hormone production by 2.5- ...
Repository : Europe PubMed Central
Language(s) : English

The complete nucleotide sequence of the human gonadotropin-releasing hormone gene.

Author(s) : Hayflick, J S , Adelman, J P , Seeburg, P H
Description :
Repository : Europe PubMed Central
Language(s) : English
1 2 3 4 5 > >>

Found 42 documents, displaying page 1 of 5