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author = "Schweighoffer, Edina"
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Found 9 documents, displaying page 1 of 1

Új eljárás a citometriás DNS szintézis mérésére

Description :
Repository : Debreceni Egyetem elektronikus Archivumanak (DEA)
Language(s) : Hungarian

CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development

Description : The C-type lectin receptor CLEC-2 signals through a pathway that is critically dependent on the tyrosine kinase Syk. We show that homozygous loss of either protein results in defects in brain vascular and lymphatic development, lung inflation and perinatal lethality. Furthermore, we find that condit...
Repository : The Univ. of Birmingham: The ePrints Archive
Language(s) : Undetermined

Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection

Description : Innate immune cells detect pathogens via pattern recognition receptors (PRRs), which signal for initiation of immune responses to infection. Studies with Dectin-1, a PRR for fungi, have defined a novel innate signaling pathway involving Syk kinase and the adaptor CARD9, which is critical for inducin...
Repository : Europe PubMed Central
Language(s) : English

LAT Is Required for Tyrosine Phosphorylation of Phospholipase Cγ2 and Platelet Activation by the Collagen Receptor GPVI

Description : In the present study, we have addressed the role of the linker for activation of T cells (LAT) in the regulation of phospholipase Cγ2 (PLCγ2) by the platelet collagen receptor glycoprotein VI (GPVI). LAT is tyrosine phosphorylated in human platelets heavily in response to collagen, collagen-related ...
Repository : Europe PubMed Central
Language(s) : English

Restoration of Pattern Recognition Receptor Costimulation to Treat Chromoblastomycosis, a Chronic Fungal Infection of the Skin

Description : Chromoblastomycosis is a chronic skin infection caused by the fungus Fonsecaea pedrosoi. Exploring the reasons underlying the chronic nature of F. pedrosoi infection in a murine model of chromoblastomycosis, we find that chronicity develops due to a lack of pattern recognition receptor (PRR) costimu...
Repository : Europe PubMed Central
Language(s) : English

Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors

Description : Recognition of microbial components by germ-line encoded pattern recognition receptors (PRR) initiates immune responses to infectious agents. We and others have proposed that pairs or sets of PRR mediate host immunity. One such pair comprises the fungal β-glucan receptor, Dectin-1, which collaborate...
Repository : Europe PubMed Central
Language(s) : English

CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development

Description : The C-type lectin receptor CLEC-2 signals through a pathway that is critically dependent on the tyrosine kinase Syk. We show that homozygous loss of either protein results in defects in brain vascular and lymphatic development, lung inflation, and perinatal lethality. Furthermore, we find that condi...
Repository : Europe PubMed Central
Language(s) : English
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Found 9 documents, displaying page 1 of 1