Results
author = "Schmid, C"
Differential binding of human nuclear proteins to Alu subfamilies.
Description :
Several diagnostic differences that distinguish human Alu subfamilies are clustered just downstream from the B box of the RNA polymerase III promoter; we tentatively refer to this diagnostic region as the DB box. Assuming that this region might determine the relative transcriptional activity of Alu ...
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Europe PubMed Central
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English
Molecular evolution of the human adult alpha-globin-like gene region: insertion and deletion of Alu family repeats and non-Alu DNA sequences.
Description :
Previous heteroduplex studies have revealed extensive sequence homology between the two human adult alpha-globin-like genes (alpha 2 and alpha 1) and their flanking regions. These homologous regions, which are interrupted by two blocks of nonhomology, each span approximately 4 kilobases [Lauer, J., ...
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Europe PubMed Central
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English
Recently transposed Alu repeats result from multiple source genes.
Description :
A human Alu repeat subfamily (the PV subfamily) whose members include insertional polymorphisms is found, as predicted, to differ by five tightly linked mutations relative to another subfamily of recently inserted Alu repeats. Based on these sequence differences some of the small number of polymorph...
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Europe PubMed Central
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English
Cell stress and translational inhibitors transiently increase the abundance of mammalian SINE transcripts.
Description :
The abundance of Alu RNA is transiently increased by heat shock in human cell lines. This effect is specific to Alu repeats among Pol III transcribed genes, since the abundance of 7SL, 7SK, 5S and U6 RNAs is essentially unaffected by heat shock. The rapid induction of Alu expression precedes the hea...
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Europe PubMed Central
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English
p53 inhibits RNA polymerase III-directed transcription in a promoter-dependent manner.
Description :
Wild-type p53 represses Alu template activity in vitro and in vivo. However, upstream activating sequence elements from both the 7SL RNA gene and an Alu source gene relieve p53-mediated repression. p53 also represses the template activity of the U6 RNA gene both in vitro and in vivo but has no effec...
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Europe PubMed Central
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English
Transcription of a human transposon-like sequence is usually directed by other promoters.
Description :
The transcriptional activity of a human transposon-like family of repeats, called the THE-1 family, has been studied in cell culture and in human tissue. Both strands of THE-1 are present in several discrete length poly A plus RNAs. Primer extension studies and the structures of cDNA clones show tha...
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Europe PubMed Central
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English
Human transposon-like elements insert at a preferred target site: evidence for a retrovirally mediated process.
Description :
Members of the human transposon-like family of repetitive sequences (called THE 1 repeats) like many other repetitive DNA sequences are flanked by short direct repeats. Comparison of the base sequences of twelve examples of these flanking direct repeats indicates that THE 1 repeats insert into a pre...
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Europe PubMed Central
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English
L and H cells of nodular lymphocyte predominant Hodgkin's disease show immunoglobulin light-chain restriction.
Description :
The nodular form of lymphocyte predominant Hodgkin's disease (NLPHD) is widely accepted to be a B-cell-derived neoplasm. Despite this consensus, previous studies have not shown monotypic immunoglobulin (Ig) light-chain expression by the putatively malignant L & H cells. We have studied paraffin-embe...
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Europe PubMed Central
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English
Recombination mediates production of an extrachromosomal circular DNA containing a transposon-like human element, THE-1.
Description :
An abundant class of HeLa extrachromosomal circular DNA containing the transposon-like element, THE-1, is shown to arise via site specific recombination. The chromosomal locus from which these circles are derived, however, is single-copy. Northern blot analysis detects homology to two polyadenylated...
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Europe PubMed Central
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English
Effects of recombinant insulin-like growth factor I on insulin secretion and renal function in normal human subjects.
Description :
Insulin-like growth factor I (IGF-I) is an important mediator of growth hormone (GH) action and it appeared tempting to evaluate possible clinical applications. Recombinant IGF-I was infused s.c. at a dose of 20 micrograms/kg of body weight per hour during 6 days in two healthy adult subjects. Blood...
Repository :
Europe PubMed Central
Language(s) :
English