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author = "Sartori, Alessandro A."
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Found 7 documents, displaying page 1 of 1

Pa-AGOG, the founding member of a new family of archaeal 8-oxoguanine DNA-glycosylases

Author(s) : Sartori, Alessandro A. , Lingaraju, Gondichatnahalli M. , Hunziker, Peter , Winkler, Fritz K. , Jiricny, Josef
Description : Oxidative damage represents a major threat to genomic stability, as the major product of DNA oxidation, 8-oxoguanine (GO), frequently mispairs with adenine during replication. In order to prevent these mutagenic events, organisms have evolved GO-DNA glycosylases that remove this oxidized base from D...
Repository : Europe PubMed Central
Language(s) : English

MRE11 complex links RECQ5 helicase to sites of DNA damage

Author(s) : Zheng, Lu , Kanagaraj, Radhakrishnan , Mihaljevic, Boris , Schwendener, Sybille , Sartori, Alessandro A. , Gerrits, Bertran
Description : RECQ5 DNA helicase suppresses homologous recombination (HR) possibly through disruption of RAD51 filaments. Here, we show that RECQ5 is constitutively associated with the MRE11–RAD50–NBS1 (MRN) complex, a primary sensor of DNA double-strand breaks (DSBs) that promotes DSB repair and regulates DNA da...
Repository : Europe PubMed Central
Language(s) : English

CtIP-dependent DNA resection is required for DNA damage checkpoint maintenance but not initiation

Author(s) : Kousholt, Arne Nedergaard , Fugger, Kasper , Hoffmann, Saskia , Larsen, Brian D. , Menzel, Tobias , Sartori, Alessandro A.
Description : CtIP-dependent DNA end resection, which was previously thought to be necessary for CHK1 kinase activation and subsequent DNA damage checkpoint induction, is in fact only required for sustained checkpoint signaling.
Repository : Europe PubMed Central
Language(s) : English

A novel uracil-DNA glycosylase with broad substrate specificity and an unusual active site

Author(s) : Sartori, Alessandro A. , Fitz-Gibbon, Sorel , Yang, Hanjing , Miller, Jeffrey H. , Jiricny, Josef
Description : Uracil-DNA glycosylases (UDGs) catalyse the removal of uracil by flipping it out of the double helix into their binding pockets, where the glycosidic bond is hydrolysed by a water molecule activated by a polar amino acid. Interestingly, the four known UDG families differ in their active site make-up...
Repository : Europe PubMed Central
Language(s) : English

γ-Radiation Promotes Immunological Recognition of Cancer Cells through Increased Expression of Cancer-Testis Antigens In Vitro and In Vivo

Author(s) : Sharma, Anu , Bode, Beata , Wenger, Roland H. , Lehmann, Kuno , Sartori, Alessandro A. , Moch, Holger , Knuth, Alexander
Description :
Repository : Europe PubMed Central
Language(s) : English

Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells

Author(s) : Toller, Isabella M. , Neelsen, Kai J. , Steger, Martin , Hartung, Mara L. , Hottiger, Michael O. , Stucki, Manuel , Kalali, Behnam
Description : The bacterial pathogen Helicobacter pylori chronically infects the human gastric mucosa and is the leading risk factor for the development of gastric cancer. The molecular mechanisms of H. pylori-associated gastric carcinogenesis remain ill defined. In this study, we examined the possibility that H....
Repository : Europe PubMed Central
Language(s) : English

RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection

Author(s) : Chapman, J. Ross , Barral, Patricia , Vannier, Jean-Baptiste , Borel, Valérie , Steger, Martin , Tomas-Loba, Antonia
Description : The appropriate execution of DNA double-strand break (DSB) repair is critical for genome stability and tumor avoidance. 53BP1 and BRCA1 directly influence DSB repair pathway choice by regulating 5′ end resection, but how this is achieved remains uncertain. Here we report that Rif1−/− mice are severe...
Repository : Europe PubMed Central
Language(s) : English
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Found 7 documents, displaying page 1 of 1