Results
author = "Sarasin, Alain"
UVSSA and USP7: new players regulating transcription-coupled nucleotide excision repair in human cells
Author(s) :
Sarasin, Alain
Description :
Transcription-coupled nucleotide excision repair (TC-NER) specifically removes DNA damage located in actively transcribed genes. Defects in TC-NER are associated with several human disorders, including Cockayne syndrome (CS) and ultraviolet (UV)-sensitive syndrome (UVSS). Using exome sequencing, and...
Repository :
Europe PubMed Central
Language(s) :
English
2nd German-French DNA repair meeting : DNA damage and repair in ageing and degenerative diseases, Konstanz, Germany, September 20-23, 2009
Description :
In September 2009, the French Society of Genetic Toxicology and the German Society for Research on DNA Repair jointly organized the 2nd German-French DNA repair meeting - DNA damage and repair in ageing and degenerative diseases , which was held in Konstanz, Germany. Here we summarize the content o...
Repository :
Univ. Konstanz: Konstanzer Online-Publikations-System (KOPS)
Language(s) :
English
Galectin-7 overexpression is associated with the apoptotic process in UVB-induced sunburn keratinocytes
Description :
Galectin-7 is a β-galactoside binding protein specifically expressed in stratified epithelia and notably in epidermis, but barely detectable in epidermal tumors and absent from squamous carcinoma cell lines. Galectin-7 gene is an early transcriptional target of the tumor suppressor protein P53 [Poly...
Repository :
Europe PubMed Central
Language(s) :
English
Effects of camptothecin on double-strand break repair by non-homologous end-joining in DNA mismatch repair-deficient human colorectal cancer cell lines
Description :
Loss of a functional mismatch repair (MMR) system in colorectal cancer (CRC) cells is associated with microsatellite instability and increased sensitivity to topoisomerase inhibitors. In this study, we have investigated whether a defect in double-strand break (DSB) repair by non-homologous end-joini...
Repository :
Europe PubMed Central
Language(s) :
English
Transcriptional Mutagenesis Induced by 8-Oxoguanine in Mammalian Cells
Description :
Most of the somatic cells of adult metazoans, including mammals, do not undergo continuous cycles of replication. Instead, they are quiescent and devote most of their metabolic activity to gene expression. The mutagenic consequences of exposure to DNA–damaging agents are well documented, but less is...
Repository :
Europe PubMed Central
Language(s) :
English
The DNA repair genes XPB and XPD defend cells from retroviral infection
Author(s) :
Yoder, Kristine
,
Sarasin, Alain
,
Kraemer, Kenneth
,
McIlhatton, Michael
,
Bushman, Frederic
,
Fishel, Richard
Description :
Reverse transcription of retroviral RNA genomes produce a double-stranded linear cDNA molecule. A host degradation system prevents a majority of the cDNA molecules from completing the obligatory genomic integration necessary for pathogenesis. We demonstrate that the human TFIIH complex proteins XPB ...
Repository :
Europe PubMed Central
Language(s) :
English
Transcription coupled repair of 8-oxoguanine in murine cells: The Ogg1 protein is required for repair in nontranscribed sequences but not in transcribed sequences
Author(s) :
Le Page, Florence
,
Klungland, Arne
,
Barnes, Deborah E.
,
Sarasin, Alain
,
Boiteux, Serge
Description :
To assess the role of the Ogg1 DNA glycosylase in the transcription-coupled repair (TCR) of the mutagenic lesion, 7,8-dihydro-8oxoguanine (8-OxoG), we have investigated the removal of this lesion in wild-type and ogg1−/− null mouse embryo fibroblast (MEF) cell lines. We used nonreplicating plasmids ...
Repository :
Europe PubMed Central
Language(s) :
English
Amplification of the Inflammatory Cellular Redox State by Human Immunodeficiency Virus Type 1-Immunosuppressive Tat and gp160 Proteins
Author(s) :
Lachgar, Abderrahim
,
Sojic, Neso
,
Arbault, Stephane
,
Bruce, Delphine
,
Sarasin, Alain
,
Amatore, Christian
,
Bizzini, Bernard
Description :
In the course of our studies on oxidative stress as a component of pathological processes in humans, we showed that microintrusion into cells with microcapillary and ultramicroelectrochemical detection could mimic many types of mechanical intrusion leading to an instant (0.1 s) and high (some femtom...
Repository :
Europe PubMed Central
Language(s) :
English
Clues to epidermal cancer proneness revealed by reconstruction of DNA repair-deficient xeroderma pigmentosum skin in vitro
Author(s) :
Bernerd, Françoise
,
Asselineau, Daniel
,
Vioux, Corinne
,
Chevallier-Lagente, Odile
,
Bouadjar, Bakar
,
Sarasin, Alain
Description :
Sun exposure has been clearly implicated in premature skin aging and neoplastic development. These features are exacerbated in patients with xeroderma pigmentosum (XP), a hereditary disease, the biochemical hallmark of which is a severe deficiency in the nucleotide excision repair of UV-induced DNA ...
Repository :
Europe PubMed Central
Language(s) :
English
High levels of patched gene mutations in basal-cell carcinomas from patients with xeroderma pigmentosum
Author(s) :
Bodak, Nathalie
,
Queille, Sophie
,
Avril, Marie Françoise
,
Bouadjar, Bakar
,
Drougard, Christiane
,
Sarasin, Alain
Description :
Recently, hptc, a human gene homologous to the Drosophila segment polarity gene patched (ptc), has been implicated in the nevoid basal-cell carcinoma (BCC) syndrome, and somatic mutations of hptc also have been found in sporadic BCCs, the most frequent cancers found in the white population. We have ...
Repository :
Europe PubMed Central
Language(s) :
English