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author = "Rocha, Miguel"
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Found 116 documents, displaying page 1 of 12

Estruturação de àreas com valor ambiental e paisagístico na AML O caso de estudo POLIS Costa da Caparica.

Author(s) : Rocha, Miguel Afonso
Description : A evolução da sociedade contemporânea tem vindo a mudar a maneira como conceptualizamos o fenómeno urbano. Os novos desafios territoriais e as novas visões de cidade têm-se traduzido, ao longo das últimas décadas, em novas respostas ao nível do projeto de grande escala na cidade europeia. O estudo d...
Repository : Repositório da Universidade Técnica de Lisboa
Language(s) : Portuguese

A computational tool for the simulation and optimization of microbial strains accounting integrated metabolic/ regulatory information

Author(s) : Vilaça, Paulo , Rocha, I. , Rocha, Miguel
Description : Background and scope Recently, a number of methods and tools have been proposed to allow the use of genome-scale metabolic models for the phenotype simulation and optimization of microbial strains, within the field of Metabolic Engineering (ME). One of the limitations of most of these algorithms and...
Repository : RepositóriUM - University of Minho Institutional Repository
Language(s) : English

Implementing metaheuristic optimization algorithms with JECoLi

Author(s) : Evangelista, Pedro , Rocha, I. , Rocha, Miguel
Description : This work proposes JECoLi - a novel Java-based library for the implementation of metaheuristic optimization algorithms with a focus on Genetic and Evolutionary Computation based methods. The library was developed based on the principles of flexibility, usability, adaptability, modularity, extensibil...
Repository : RepositóriUM - University of Minho Institutional Repository
Language(s) : English

Preventing premature convergence to local optima in genetic algorithms via random offspring generation

Author(s) : Rocha, Miguel , Neves, José
Description : The Genetic Algorithms (GAs) paradigm is being used increasingly in search and optimization problems. The method has shown to be efficient and robust in a considerable number of scientific domains, where the complexity and cardinality of the problems considered elected themselves as key factors to b...
Repository : RepositóriUM - University of Minho Institutional Repository
Language(s) : English

Systems Biology for the development of microbial cell factories

Author(s) : Rocha, I. , Lourenço, Anália , Rocha, Miguel , Ferreira, E. C.
Description :
Repository : RepositóriUM - University of Minho Institutional Repository
Language(s) : English

Evolutionary approaches for strain optimization using dynamic models under a metabolic engineering perspective

Author(s) : Evangelista, Pedro , Rocha, I. , Ferreira, E. C. , Rocha, Miguel
Description : One of the purposes of Systems Biology is the quantitative modeling of biochemical networks. In this effort, the use of dynamical mathematical models provides for powerful tools in the prediction of the phenotypical behavior of microorganisms under distinct environmental conditions or subject to gen...
Repository : RepositóriUM - University of Minho Institutional Repository
Language(s) : English

Highlighting metabolic strategies using network analysis over strain optimization results

Author(s) : Pinto, José P. , Rocha, I. , Rocha, Miguel
Description : The field of Metabolic Engineering has been growing, sup- ported by the increase in the number of annotated genomes and genome- scale metabolic models. In silico strain optimization methods allow to create mutant strains able to overproduce certain metabolites of interest in Biotechnology. Thus, it ...
Repository : RepositóriUM - University of Minho Institutional Repository
Language(s) : English

Evaluating evolutionary multiobjective algorithms for the in silico optimization of mutant strains

Author(s) : Maia, Paulo , Rocha, I. , Ferreira, E. C. , Rocha, Miguel
Description : In Metabolic Engineering, the identification of genetic manipulations that lead to mutant strains able to produce a given compound of interest is a promising, while still complex process. Evolutionary Algorithms (EAs) have been a successful approach for tackling the underlying in silico optimization...
Repository : RepositóriUM - University of Minho Institutional Repository
Language(s) : English

A software tool for the simulation and optimization of dynamic metabolic models

Author(s) : Evangelista, Pedro , Rocha, I. , Ferreira, E. C. , Rocha, Miguel
Description : In Systems Biology, there is a growing need for simulation and optimization tools for the prediction of the phenotypical behavior of microorganisms. In this paper, an open-source software platform is proposed to provide support for research in Metabolic Engineering, by implementing tools that enable...
Repository : RepositóriUM - University of Minho Institutional Repository
Language(s) : English

A comparison of algorithms for the optimization of fermentation processes

Author(s) : Mendes, Rui , Rocha, I. , Ferreira, E. C. , Rocha, Miguel
Description : The optimization of biotechnological processes is a complex problem that has been intensively studied in the past few years due to the economic impact of the products obtained from fermentations. In fed-batch processes, the goal is to find the optimal feeding trajectory that maximizes the final prod...
Repository : RepositóriUM - University of Minho Institutional Repository
Language(s) : English
1 2 3 4 5 > >>

Found 116 documents, displaying page 1 of 12