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author = "Robert, Séverine"
1
Found 9 documents, displaying page 1 of 1
Description globale de la structure de vibration-rotaton de la molécule d'acétylène / Global description of the vibration-rotation structure of the molecule of acetylene
Author(s) :
Robert, Séverine
Description :
Afin de progresser dans la compréhension de la structure de vibration-rotation de l'acétylène dans son état électronique fondamental, un modèle global a été développé avec succès pour trois de ses isotopologues, permettant d'attribuer de nouvelles données de spectres enregistrés sous diverses condit...
Repository :
DI-fusion
Language(s) :
Undetermined
Novel 3-carboxamide-coumarins as potent and selective FXIIa inhibitors.
Author(s) :
Robert, Séverine
,
Bertolla, Carine
,
Masereel, Bernard
,
Dogné, Jean-Michel
,
Pochet, Lionel
Description :
Recently, FXIIa was highlighted as an original attractive target for the development of new anticoagulant drugs with low rates of therapy-related hemorrhages. In this work, we describe the development of a new series of 3-carboxamide-coumarins that are the first potent and selective nonpeptidic inhi...
Repository :
DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) :
English
Effects of leaf extracts from Croton zambesicus Muell. Arg. on hemostasis
Author(s) :
Robert, Severine
,
Baccelli, Chiara
,
Devel, Philippe
,
Dogne, Jean-Michel
,
Quetin-Leclercq, Joelle
Description :
Ethnopharmacological relevance: The leaf decoction of Croton zambesicus Muell. Arg. (Euphorbiaceae; syn. Croton amabilis Muell. Arg., Croton gratissimus Burch) is traditionally used in Benin to treat hypertension. Aim of the study: As hypertension and thromboembolism are often associated in several ...
Repository :
DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) :
English
Investigation of mechanism-based thrombin inhibitors: Implications of a highly conserved water molecule for the binding of coumarins within the S pocket.
Author(s) :
Frédérick, Raphaël
,
Charlier, Caroline
,
Robert, Séverine
,
Wouters, Johan
,
Masereel, Bernard
,
Pochet, Lionel
Description :
The synthesis of novel coumarins bearing on the lateral side chain in the 3-position an amine or a guanidine group is described. In vitro evaluation highlighted 14d which possesses a meta aniline side chain as a very potent THR inhibitor. Surprisingly, the introduction of a guanidine moiety always l...
Repository :
DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) :
English
Mechanism-based thrombin inhibitors: design, synthesis, and molecular docking of a new selective 2-oxo-2H-1-benzopyran derivative.
Author(s) :
Frédérick, Raphaël
,
Robert, Séverine
,
Charlier, Caroline
,
Wouters, Johan
,
Masereel, Bernard
,
Pochet, Lionel
Description :
New 2-oxo-2H-1-benzopyran derivatives were prepared to optimize 2a,b, initially developed as mechanism-based alpha-chymotrypsin (alpha-CT) inhibitors, into potent and selective thrombin (THR) inhibitors. From this study, 22, characterized by a 2-(N-ethyl-2'-oxoacetamide)-5'-chlorophenyl ester side c...
Repository :
DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) :
English
Is thrombin generation the new rapid, reliable and relevant pharmacological tool for the development of anticoagulant drugs?
Author(s) :
Robert, Séverine
,
Ghiotto, Jérémie
,
Pirotte, Bernard
,
David, Jean-Louis
,
Masereel, Bernard
,
Pochet, Lionel
,
Dogné, Jean-Michel
Description :
The ex vivo testing emerges as an essential and critical step for the selection of the most promising prospective anticoagulant agents. The aim of the present study was to validate the thrombin generation assay as an ex vivo pharmacological screening test for measuring the anticoagulant behaviour an...
Repository :
DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) :
English
3,6-disubstituted coumarins as mechanism-based inhibitors of thrombin and factor Xa.
Author(s) :
Frédérick, Raphaël
,
Robert, Séverine
,
Charlier, Caroline
,
de Ruyck, Jérôme
,
Wouters, Johan
,
Pirotte, Bernard
,
Masereel, Bernard
Description :
In this work, coumarins were screened on thrombin (THR) and factor Xa (FXa), two of the most promising targets for the development of anticoagulant drugs. This allowed us to highlight compound 30, characterized by a 2,5-dichlorophenyl ester in the 3-position and a chloromethyl moiety in the 6-positi...
Repository :
DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) :
English
Ir-CPI, a coagulation contact phase inhibitor from the tick Ixodes ricinus, inhibits thrombus formation without impairing hemostasis
Author(s) :
Decrem, Yves
,
Rath, Géraldine
,
Blasioli, Virginie
,
Cauchie, Philippe
,
Robert, Severine
,
Beaufays, Jerome
,
Frere, Jean-Marie
Description :
Blood coagulation starts immediately after damage to the vascular endothelium. This system is essential for minimizing blood loss from an injured blood vessel but also contributes to vascular thrombosis. Although it has long been thought that the intrinsic coagulation pathway is not important for cl...
Repository :
DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) :
English
Ir-CPI, a coagulation contact phase inhibitor from the tick Ixodes ricinus, inhibits thrombus formation without impairing hemostasis
Author(s) :
Decrem, Yves
,
Rath, Géraldine
,
Blasioli, Virginie
,
Cauchie, Philippe
,
Robert, Séverine
,
Beaufays, Jérôme
,
Frère, Jean-Marie
Description :
Blood coagulation starts immediately after damage to the vascular endothelium. This system is essential for minimizing blood loss from an injured blood vessel but also contributes to vascular thrombosis. Although it has long been thought that the intrinsic coagulation pathway is not important for cl...
Repository :
Europe PubMed Central
Language(s) :
English
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Found 9 documents, displaying page 1 of 1