Results
author = "Rizzuto, A"
Novel role for polycystin-1 in modulating cell proliferation through calcium oscillations in kidney cells
Author(s) :
Aguiari, G
,
Trimi, V
,
Bogo, M
,
Mangolini, A
,
Szabadkai, G
,
Pinton, P
,
Witzgall, R
,
Harris, P C
,
Borea, P A
,
Rizzuto, R
Description :
Objectives: Polycystin-1 (PC1), a signalling receptor regulating Ca2+-permeable cation channels, is mutated in autosomal dominant polycystic kidney disease, which is typically characterized by increased cell proliferation. However, the precise mechanisms by which PC1 functions on Ca2+ homeostasis, s...
Repository :
Europe PubMed Central
Language(s) :
English
Development of Animal Models for Adeno-Associated Virus Site-Specific Integration
Author(s) :
Rizzuto, Gabriella
,
Gorgoni, Barbara
,
Cappelletti, Manuela
,
Lazzaro, Domenico
,
Gloaguen, Isabelle
,
Poli, Valeria
Description :
The adeno-associated virus (AAV) is unique in its ability to target viral DNA integration to a defined region of human chromosome 19 (AAVS1). Since AAVS1 sequences are not conserved in a rodent’s genome, no animal model is currently available to study AAV-mediated site-specific integration. We descr...
Repository :
Europe PubMed Central
Language(s) :
English
Modulation of Caspase Activity Regulates Skeletal Muscle Regeneration and Function in Response to Vasopressin and Tumor Necrosis Factor
Author(s) :
Moresi, Viviana
,
Garcia-Alvarez, Gisela
,
Pristerà, Alessandro
,
Rizzuto, Emanuele
,
Albertini, Maria C.
,
Rocchi, Marco
Description :
Muscle homeostasis involves de novo myogenesis, as observed in conditions of acute or chronic muscle damage. Tumor Necrosis Factor (TNF) triggers skeletal muscle wasting in several pathological conditions and inhibits muscle regeneration. We show that intramuscular treatment with the myogenic factor...
Repository :
Europe PubMed Central
Language(s) :
English
Efficient and regulated erythropoietin production by naked DNA injection and muscle electroporation
Author(s) :
Rizzuto, Gabriella
,
Cappelletti, Manuela
,
Maione, Domenico
,
Savino, Rocco
,
Lazzaro, Domenico
,
Costa, Patrizia
,
Mathiesen, Iacob
Description :
We show that an electric treatment in the form of high-frequency, low-voltage electric pulses can increase more than 100-fold the production and secretion of a recombinant protein from mouse skeletal muscle. Therapeutical erythopoietin (EPO) levels were achieved in mice with a single injection of as...
Repository :
Europe PubMed Central
Language(s) :
English
Molecular, cellular and physiological characterization of the cancer cachexia-inducing C26 colon carcinoma in mouse
Author(s) :
Aulino, Paola
,
Berardi, Emanuele
,
Cardillo, Veronica M
,
Rizzuto, Emanuele
,
Perniconi, Barbara
,
Ramina, Carla
,
Padula, Fabrizio
Description :
Repository :
Europe PubMed Central
Language(s) :
English
A V3 Loop-Dependent gp120 Element Disrupted by CD4 Binding Stabilizes the Human Immunodeficiency Virus Envelope Glycoprotein Trimer▿
Author(s) :
Xiang, Shi-Hua
,
Finzi, Andrés
,
Pacheco, Beatriz
,
Alexander, Kevin
,
Yuan, Wen
,
Rizzuto, Carlo
,
Huang, Chih-Chin
,
Kwong, Peter D.
Description :
Human immunodeficiency virus (HIV-1) entry into cells is mediated by a trimeric complex consisting of noncovalently associated gp120 (exterior) and gp41 (transmembrane) envelope glycoproteins. The binding of gp120 to receptors on the target cell alters the gp120-gp41 relationship and activates the m...
Repository :
Europe PubMed Central
Language(s) :
English
Translocation of signalling proteins to the plasma membrane revealed by a new bioluminescent procedure
Author(s) :
Giorgi, Carlotta
,
Romagnoli, Anna
,
Agnoletto, Chiara
,
Bergamelli, Leda
,
Sorrentino, Giovanni
,
Brini, Marisa
,
Pozzan, Tullio
Description :
Repository :
Europe PubMed Central
Language(s) :
English
Embryonic and foetal Islet-1 positive cells in human hearts are also positive to c-Kit
Author(s) :
Serradifalco, C.
,
Catanese, P.
,
Rizzuto, L.
,
Cappello, F.
,
Puleio, R.
,
Barresi, V.
,
Nunnari, C.M.
,
Zummo, G.
,
Di Felice, V.
Description :
During embryogenesis, the mammalian heart develops from a primitive heart tube originating from two bilateral primary heart fields located in the lateral plate mesoderm. Cells belongings to the pre-cardiac mesoderm will differentiate into early cardiac progenitors, which express early transcription ...
Repository :
Europe PubMed Central
Language(s) :
English
The Mitochondrial Ca2+ Uniporter MCU Is Essential for Glucose-Induced ATP Increases in Pancreatic β-Cells
Author(s) :
Tarasov, Andrei I.
,
Semplici, Francesca
,
Ravier, Magalie A.
,
Bellomo, Elisa A.
,
Pullen, Timothy J.
,
Gilon, Patrick
Description :
Glucose induces insulin release from pancreatic β-cells by stimulating ATP synthesis, membrane depolarisation and Ca2+ influx. As well as activating ATP-consuming processes, cytosolic Ca2+ increases may also potentiate mitochondrial ATP synthesis. Until recently, the ability to study the role of mit...
Repository :
Europe PubMed Central
Language(s) :
English
Extracellular ATP Causes ROCK I-dependent Bleb Formation in P2X7-transfected HEK293 CellsV⃞
Author(s) :
Morelli, Anna
,
Chiozzi, Paola
,
Chiesa, Anna
,
Ferrari, Davide
,
Sanz, Juana M.
,
Falzoni, Simonetta
,
Pinton, Paolo
,
Rizzuto, Rosario
Description :
The P2X7 ATP receptor mediates the cytotoxic effect of
extracellular ATP. P2X7-dependent cell death is heralded by
dramatic plasma membrane bleb formation. Membrane blebbing is a complex
phenomenon involving as yet poorly characterized intracellular pathways. We
have investigated the effect of e...
Repository :
Europe PubMed Central
Language(s) :
English