Results
author = "Reynaud, Claude-Agnès"
Gene profiling of CD11b+ and CD11b− B1 cell subsets reveals potential cell sorting artifacts
Description :
Repository :
Europe PubMed Central
Language(s) :
English
Splenic marginal zone B cells in humans: where do they mutate their Ig receptor?
Description :
Human IgM+ IgD+ CD27+ B cells have mutated Ig genes and harbor a splenic marginal zone (MZ) phenotype. In this issue, the group of R. K?rs has studied the expression of the enzyme activation-induced cytidine deaminase (AID) in human spleen samples by immunocytochemistry and failed to detect a signif...
Repository :
HAL - Hyper Article on Line
Language(s) :
English
Vaccination against encapsulated bacteria in humans: paradoxes.
Description :
Infection with encapsulated bacteria can be prevented by vaccination with capsular polysaccharides, either plain or conjugated to a protein carrier. However, results concerning these vaccinations raise several paradoxes. Polysaccharides from encapsulated bacteria are generally considered to be T cel...
Repository :
HAL - Hyper Article on Line
Language(s) :
English
Proteasomal degradation restricts the nuclear lifespan of AID
Author(s) :
Aoufouchi, Said
,
Faili, Ahmad
,
Zober, Carole
,
D'Orlando, Orietta
,
Weller, Sandra
,
Weill, Jean-Claude
,
Reynaud, Claude-Agnès
Description :
Activation-induced cytidine deaminase (AID) initiates all postrearrangement processes that diversify the immunoglobulin repertoire by specific deamination of cytidines at the immunoglobulin (Ig) locus. As uncontrolled expression of AID is potentially mutagenic, different types of regulation, particu...
Repository :
Europe PubMed Central
Language(s) :
English
Somatic diversification in the absence of antigen-driven responses is the hallmark of the IgM+IgD+CD27+ B cell repertoire in infants
Author(s) :
Weller, Sandra
,
Mamani-Matsuda, Maria
,
Picard, Capucine
,
Cordier, Corinne
,
Lecoeuche, Damiana
,
Gauthier, Frédéric
Description :
T cell–dependent immune responses develop soon after birth, whereas it takes 2 yr for humans to develop T cell–independent responses. We used this dissociation to analyze the repertoire diversification of IgM+IgD+CD27+ B cells (also known as “IgM memory” B cells), comparing these cells with switched...
Repository :
Europe PubMed Central
Language(s) :
English
Normal Immune System Development in Mice Lacking the Deltex-1 RING Finger Domain
Author(s) :
Storck, Sébastien
,
Delbos, Frédéric
,
Stadler, Nicolas
,
Thirion-Delalande, Catherine
,
Bernex, Florence
,
Verthuy, Christophe
Description :
The Notch signaling pathway controls several cell fate decisions during lymphocyte development, from T-cell lineage commitment to the peripheral differentiation of B and T lymphocytes. Deltex-1 is a RING finger ubiquitin ligase which is conserved from Drosophila to humans and has been proposed to be...
Repository :
Europe PubMed Central
Language(s) :
English
Two novel human and mouse DNA polymerases of the polX family
Author(s) :
Aoufouchi, Said
,
Flatter, Eric
,
Dahan, Auriel
,
Faili, Ahmad
,
Bertocci, Barbara
,
Storck, Sebastien
,
Delbos, Frédéric
Description :
We describe here two novel mouse and human DNA polymerases: one (pol λ) has homology with DNA polymerase β while the other one (pol µ) is closer to terminal deoxynucleotidyltransferase. However both have DNA polymerase activity in vitro and share similar structural organization, including a BRCT dom...
Repository :
Europe PubMed Central
Language(s) :
English
A Targeted Deletion of a Region Upstream from the Jκ Cluster Impairs κ Chain Rearrangement In Cis in Mice and in the 103/bcl2 Cell Line
Author(s) :
Cocea, Laurentiu
,
De Smet, Annie
,
Saghatchian, Mahasti
,
Fillatreau, Simon
,
Ferradini, Laurent
,
Schurmans, Stéphane
Description :
We have shown previously that a mutation of the KI-KII site immediately 5′ to Jκ1 on the mouse immunoglobulin light chain κ locus reduces the rearrangement level in cis, although it does not affect transcription. Here we deleted by homologous recombination in mouse embryonic stem cells a 4-kb DNA ...
Repository :
Europe PubMed Central
Language(s) :
English
Normal immune system development in mice lacking the Deltex-1 RING finger domain.
Author(s) :
Storck, Sébastien
,
Delbos, Frédéric
,
Stadler, Nicolas
,
Thirion-Delalande, Catherine
,
Bernex, Florence
,
Verthuy, Christophe
Description :
The Notch signaling pathway controls several cell fate decisions during lymphocyte development, from T-cell lineage commitment to the peripheral differentiation of B and T lymphocytes. Deltex-1 is a RING finger ubiquitin ligase which is conserved from Drosophila to humans and has been proposed to be...
Repository :
HAL - Hyper Article on Line
Language(s) :
English
Proteasomal degradation restricts the nuclear lifespan of AID.
Author(s) :
Aoufouchi, Said
,
Faili, Ahmad
,
Zober, Carole
,
D'Orlando, Orietta
,
Weller, Sandra
,
Weill, Jean-Claude
,
Reynaud, Claude-Agnès
Description :
Activation-induced cytidine deaminase (AID) initiates all postrearrangement processes that diversify the immunoglobulin repertoire by specific deamination of cytidines at the immunoglobulin (Ig) locus. As uncontrolled expression of AID is potentially mutagenic, different types of regulation, particu...
Repository :
HAL - Hyper Article on Line
Language(s) :
English