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author = "Reyburn, Hugh"

Found 68 documents, displaying page 2 of 7

Abandoning presumptive antimalarial treatment for febrile children aged less than five years - a case of running before we can walk?

Description : Citation: English, M. et al. (2009). 'Abandoning presumptive antimalarial treatment for febrile children aged less than five years - a case of running before we can walk?', PLoS Medicine, 6(1): e1000015. [Available at http://journals.plos.org/plosmedicine]. © 2009 English et al. This is an open-acce...
Repository : Oxford University Research Archive (ORA)
Language(s) : English

Expression of the UL16 glycoprotein of Human Cytomegalovirus protects the virus-infected cell from attack by natural killer cells

Description : Abstract Background Human Cytomegalovirus (HCMV) has acquired through evolution a number of genes to try to evade immune recognition of the virus-infected cell. Many of these mechanisms act to inhibit the MHC class I antigen presentation pathway, but any virus-infected cell which has down-regulated ...
Repository : DSpace at Cambridge
Language(s) : English

Abandoning Presumptive Antimalarial Treatment for Febrile Children Aged Less Than Five Years—A Case of Running Before We Can Walk?

Description : Background to the debate: Current guidelines recommend that all fever episodes in African children be treated presumptively with antimalarial drugs. But declining malarial transmission in parts of sub-Saharan Africa, declining proportions of fevers due to malaria, and the availability of rapid diagn...
Repository : Europe PubMed Central
Language(s) : English

Genetic Variability of the Major Histocompatibility Complex Class I Homologue Encoded by Human Cytomegalovirus Leads to Differential Binding to the Inhibitory Receptor ILT2†

Description : Human cytomegalovirus carries a gene, UL18, that is homologous to cellular major histocompatibility complex (MHC) class I genes. Like MHC class I molecules, the protein product of the UL18 gene associates with β2-microglobulin, and the stability of this complex depends on peptide loading. UL18 prote...
Repository : Europe PubMed Central
Language(s) : English

A Nested-PCR-Based Schizodeme Method for Identifying Leishmania Kinetoplast Minicircle Classes Directly from Clinical Samples and Its Application to the Study of the Epidemiology of Leishmania tropica in Pakistan

Description : A nested PCR was developed to amplify the variable region of the kinetoplast minicircles of all Leishmania species which infect mammals. Each Leishmania parasite contains approximately 10,000 kinetoplast DNA minicircles, which are unequally distributed among approximately 10 minicircle classes. The ...
Repository : Europe PubMed Central
Language(s) : English

Human NKG2D-ligands: cell biology strategies to ensure immune recognition

Description : Immune recognition mediated by the activating receptor NKG2D plays an important role for the elimination of stressed cells, including tumors and virus-infected cells. On the other hand, the ligands for NKG2D can also be shed into the sera of cancer patients where they weaken the immune response by d...
Repository : Europe PubMed Central
Language(s) : English

Found 68 documents, displaying page 2 of 7