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author = "Redelinghuys, Pierre"
1

Found 5 documents, displaying page 1 of 1

Inhibitory C-type lectin receptors in myeloid cells

Author(s) : Redelinghuys, Pierre , Brown, Gordon D.
Description : C-type lectin receptors encoded by the natural killer gene complex play critical roles in enabling NK cell discrimination between self and non-self. In recent years, additional genes at this locus have been identified with patterns of expression that extend to cells of the myeloid lineage where many...
Repository : Europe PubMed Central
Language(s) : English

Dectin-1 Is Not Required for Controlling Candida albicans Colonization of the Gastrointestinal Tract

Author(s) : Vautier, Simon , Drummond, Rebecca A. , Redelinghuys, Pierre , Murray, Graeme I. , MacCallum, Donna M. , Brown, Gordon D.
Description : Candida albicans is normally found as a commensal microbe, commonly colonizing the gastrointestinal tract in humans. However, this fungus can also cause mucosal and systemic infections once immune function is compromised. Dectin-1 is an innate pattern recognition receptor essential for the control o...
Repository : Europe PubMed Central
Language(s) : English

The N Domain of Human Angiotensin-I-converting Enzyme: THE ROLE OF N-GLYCOSYLATION AND THE CRYSTAL STRUCTURE IN COMPLEX WITH AN N DOMAIN-SPECIFIC PHOSPHINIC INHIBITOR, RXP407*

Author(s) : Anthony, Colin S. , Corradi, Hazel R. , Schwager, Sylva L. U. , Redelinghuys, Pierre , Georgiadis, Dimitris , Dive, Vincent
Description : Angiotensin-I-converting enzyme (ACE) plays a critical role in the regulation of blood pressure through its central role in the renin-angiotensin and kallikrein-kinin systems. ACE contains two domains, the N and C domains, both of which are heavily glycosylated. Structural studies of ACE have been f...
Repository : Europe PubMed Central
Language(s) : English

Early Murine T-lymphocyte Activation Is Accompanied by a Switch from N-Glycolyl- to N-Acetyl-neuraminic Acid and Generation of Ligands for Siglec-E*

Author(s) : Redelinghuys, Pierre , Antonopoulos, Aristotelis , Liu, Yan , Campanero-Rhodes, Maria A. , McKenzie, Emma , Haslam, Stuart M.
Description : It is well established that murine T-lymphocyte activation is accompanied by major changes in cell-surface sialylation, potentially influencing interactions with sialic acid-binding immunoglobulin-like lectins (siglecs). In the present study, we analyzed early activation of murine CD4+ and CD8+ T-ly...
Repository : Europe PubMed Central
Language(s) : English

Characterisation of Innate Fungal Recognition in the Lung

Author(s) : Faro-Trindade, Inês , Willment, Janet A. , Kerrigan, Ann M. , Redelinghuys, Pierre , Hadebe, Sabelo , Reid, Delyth M.
Description : The innate recognition of fungi by leukocytes is mediated by pattern recognition receptors (PRR), such as Dectin-1, and is thought to occur at the cell surface triggering intracellular signalling cascades which lead to the induction of protective host responses. In the lung, this recognition is aide...
Repository : Europe PubMed Central
Language(s) : English
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Found 5 documents, displaying page 1 of 1