Results
author = "Pozzan, T"
Calcium influx and mitochondrial alterations at synapses exposed to snake neurotoxins or their phospholipid hydrolysis products
Author(s) :
Rigoni, M
,
Pizzo, P
,
Schiavo, G
,
Weston, AE
,
Zatti, G
,
Caccin, P
,
Rossetto, O
,
Pozzan, T
,
Montecucco, C
Description :
Repository :
UCL Eprints
Language(s) :
Undetermined
Dystrophin muscle enhancer 1 is implicated in the activation of non-muscle isoforms in the skeletal muscle of patients with X-linked dilated cardiomyopathy
Author(s) :
Bastianutto, C
,
Bestard, JA
,
Lahnakoski, K
,
Broere, D
,
De Visser, M
,
Zaccolo, M
,
Pozzan, T
,
Ferlini, A
,
Muntoni, F
,
Patarnello, T
Description :
X-linked dilated cardiomyopathy (XLDC) is a dystrophinopathy characterized by severe cardiomyopathy with no skeletal muscle involvement. Several XLDC patients have been described with mutations that abolish dystrophin muscle (M) isoform expression. The absence of skeletal muscle degeneration normall...
Repository :
UCL Eprints
Language(s) :
Undetermined
Mitochondrial matrix pH controls oxidative phosphorylation and metabolism-secretion coupling in INS-1E clonal beta cells.
Description :
Glucose-evoked mitochondrial signals augment ATP synthesis in the pancreatic β cell. This activation of energy metabolism increases the cytosolic ATP/ADP ratio, which stimulates plasma membrane electrical activity and insulin granule exocytosis. We have recently demonstrated that matrix pH increases...
Repository :
Oxford University Research Archive (ORA)
Language(s) :
English
Myosin Va cooperates with PKA RIalpha to mediate maintenance of the endplate in vivo.
Description :
Myosin V motor proteins facilitate recycling of synaptic receptors, including AMPA and acetylcholine receptors, in central and peripheral synapses, respectively. To shed light on the regulation of receptor recycling, we employed in vivo imaging of mouse neuromuscular synapses. We found that myosin V...
Repository :
Oxford University Research Archive (ORA)
Language(s) :
English
Interaction of lymphokine-activated killer cells with susceptible targets does not induce second messenger generation and cytolytic granule exocytosis.
Description :
CTL activation by specific targets leads to a rapid rise of inositol phosphates (InsPs) and of cytoplasmic-free Ca2+ concentration ([Ca2+]i). While these events are considered necessary to trigger granule secretion, Ca2+-independent cytolytic mechanisms have been recently proposed in addition or as ...
Repository :
Oxford University Research Archive (ORA)
Language(s) :
English
Termination of cAMP signals by Ca2+ and Gαi via extracellular Ca2+ sensors: a link to intracellular Ca2+ oscillations
Author(s) :
Gerbino, Andrea
,
Ruder, Warren C.
,
Curci, Silvana
,
Pozzan, Tullio
,
Zaccolo, Manuela
,
Hofer, Aldebaran M.
Description :
Termination of cyclic adenosine monophosphate (cAMP) signaling via the extracellular Ca2+-sensing receptor (CaR) was visualized in single CaR-expressing human embryonic kidney (HEK) 293 cells using ratiometric fluorescence resonance energy transfer–dependent cAMP sensors based on protein kinase A an...
Repository :
Europe PubMed Central
Language(s) :
English
Subcellular analysis of Ca2+ homeostasis in primary cultures of skeletal muscle myotubes.
Author(s) :
Brini, M
,
De Giorgi, F
,
Murgia, M
,
Marsault, R
,
Massimino, M L
,
Cantini, M
,
Rizzuto, R
,
Pozzan, T
Description :
Specifically targeted aequorin chimeras were used for studying the dynamic changes of Ca2+ concentration in different subcellular compartments of differentiated skeletal muscle myotubes. For the cytosol, mitochondria, and nucleus, the previously described chimeric aequorins were utilized; for the sa...
Repository :
Europe PubMed Central
Language(s) :
English
CXCR4–CCR5: A couple modulating T cell functions
Author(s) :
Contento, Rita Lucia
,
Molon, Barbara
,
Boularan, Cedric
,
Pozzan, Tullio
,
Manes, Santos
,
Marullo, Stefano
,
Viola, Antonella
Description :
Chemokines and their receptors direct leukocyte migration among blood, lymph and tissues. Evidence has recently accumulated that, besides their chemotactic functions, chemokine receptors are highly versatile players that fine tune immune responses. During human T cell activation by antigen-presentin...
Repository :
Europe PubMed Central
Language(s) :
English
Ca2+ Homeostasis in the Endoplasmic Reticulum: Coexistence of High and Low [Ca2+] Subcompartments in Intact HeLa Cells
Author(s) :
Montero, Mayte
,
Alvarez, Javier
,
Scheenen, Wilhelm J.J.
,
Rizzuto, Rosario
,
Meldolesi, Jacopo
,
Pozzan, Tullio
Description :
Two recombinant aequorin isoforms with different Ca2+ affinities, specifically targeted to the endoplasmic reticulum (ER), were used in parallel to investigate free Ca2+ homeostasis in the lumen of this organelle. Here we show that, although identically and homogeneously distributed in the ER syst...
Repository :
Europe PubMed Central
Language(s) :
English
Ca2+ oscillation frequency decoding in cardiac cell hypertrophy: Role of calcineurin/NFAT as Ca2+ signal integrators
Author(s) :
Colella, Matilde
,
Grisan, Francesca
,
Robert, Valerie
,
Turner, Jay D.
,
Thomas, Andrew P.
,
Pozzan, Tullio
Description :
The role of Ca2+ signaling in triggering hypertrophy was investigated in neonatal rat cardiomyocytes in vitro. We show that an increase in cell size and sarcomere reorganization were elicited by receptor agonists such as Angiotensin II, aldosterone, and norepinephrine and by a small rise in medium K...
Repository :
Europe PubMed Central
Language(s) :
English