Results
author = "Pozzan, T"
The Pathophysiology of LETM1
Author(s) :
Nowikovsky, Karin
,
Pozzan, Tullio
,
Rizzuto, Rosario
,
Scorrano, Luca
,
Bernardi, Paolo
Description :
Repository :
Europe PubMed Central
Language(s) :
English
Free cytoplasmic Ca2+ and neurotransmitter release: studies on PC12 cells and synaptosomes exposed to alpha-latrotoxin.
Description :
The relationship between the free cytoplasmic Ca2+ concentration, [Ca2+]i, and neurotransmitter release was investigated in guinea pig brain synaptosomes and the neurosecretory cell line PC12. Release was induced by alpha-latrotoxin, which acts in both Ca2+ -containing and Ca2+ -free incubation medi...
Repository :
Europe PubMed Central
Language(s) :
English
Free [Ca2+] dynamics measured in agonist-sensitive stores of single living intact cells: a new look at the refilling process.
Description :
Free [Ca2+] in agonist-sensitive internal stores of single intact cells was measured in situ in order to examine the role of [Ca2+] in modulating the store refilling process. BHK-21 fibroblasts were loaded with the low-affinity fluorescent calcium indicator mag-fura-2-AM such that >80% of the dye wa...
Repository :
Europe PubMed Central
Language(s) :
English
Direct in vivo monitoring of sarcoplasmic reticulum Ca2+ and cytosolic cAMP dynamics in mouse skeletal muscle
Description :
Skeletal muscle contraction depends on the release of Ca2+ from the sarcoplasmic reticulum (SR), but the dynamics of the SR free Ca2+ concentration ([Ca2+]SR), its modulation by physiological stimuli such as catecholamines, and the concomitant changes in cAMP handling have never been directly determ...
Repository :
Europe PubMed Central
Language(s) :
English
In vivo monitoring of Ca2+ uptake into mitochondria of mouse skeletal muscle during contraction
Description :
Although the importance of mitochondria in patho-physiology has become increasingly evident, it remains unclear whether these organelles play a role in Ca2+ handling by skeletal muscle. This undefined situation is mainly due to technical limitations in measuring Ca2+ transients reliably during the c...
Repository :
Europe PubMed Central
Language(s) :
English
Phorbol myristate acetate stimulates ATP-dependent calcium transport by the plasma membrane of neutrophils.
Description :
We studied the effect of phorbol myristate acetate (PMA) on the plasma membrane ATP-dependent calcium pump in neutrophils. Plasma membrane-enriched fractions ("podosomes") from PMA-stimulated guinea pig neutrophils exhibited a twofold stimulation of ATP-dependent calcium transport when compared with...
Repository :
Europe PubMed Central
Language(s) :
English
Endoplasmic reticulum, Bcl-2 and Ca2+ handling in apoptosis
Author(s) :
Ferrari, D
,
Pinton, P
,
Szabadkai, G
,
Chami, M
,
Campanella, M
,
Pozzan, T
,
Rizzuto, R
Description :
In the complex signalling interplay that allows extracellular signals to be decoded into activation of apoptotic cell death, Ca2+ plays a significant role. This is supported not only by evidence linking alterations in Ca2+ homeostasis to the triggering of apoptotic (and in some cases necrotic) cell ...
Repository :
UCL Eprints
Language(s) :
Undetermined
Odorant receptors at the growth cone are coupled to localized cAMP and Ca2+ increases.
Description :
A distinctive feature in the topographic organization of the olfactory system in mammals is the dual function of the odorant receptor (OR): it detects odors in the nasal epithelium and plays an instructive role in the axonal convergence of olfactory sensory neurons (OSN) into the olfactory bulb (OB)...
Repository :
Oxford University Research Archive (ORA)
Language(s) :
English
Calcium and inositolphosphates in the activation of T cell-mediated cytotoxicity.
Description :
Reports from a number of laboratories have shown that mAbs against the T3-Ti receptor complex cause an increase in cytosolic-free Ca2+ [( Ca2+]i) and the hydrolysis of phosphatidylinositolbisphosphate (PIP2) in CTLs. In the present report we show that activation of CTLs by their specific targets cau...
Repository :
Oxford University Research Archive (ORA)
Language(s) :
English
Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis
Author(s) :
Bassik, Michael C
,
Scorrano, Luca
,
Oakes, Scott A
,
Pozzan, Tullio
,
Korsmeyer, Stanley J
Description :
Phosphorylation of BCL-2 within an unstructured loop inhibits its antiapoptotic effect. We found that phosphorylated BCL-2 predominantly localized to the endoplasmic reticulum (ER) and tested whether phosphorylation would control its activity at this organelle, where Ca2+ dynamics serve as a critica...
Repository :
Europe PubMed Central
Language(s) :
English