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author = "Pinton, P"
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Found 25 documents, displaying page 1 of 3

The Golgi apparatus is an inositol 1,4,5-trisphosphate-sensitive Ca2+ store, with functional properties distinct from those of the endoplasmic reticulum.

Author(s) : Pinton, P , Pozzan, T , Rizzuto, R
Description : In the past few years, intracellular organelles, such as the endoplasmic reticulum, the nucleus and the mitochondria, have emerged as key determinants in the generation and transduction of Ca2+ signals of high spatio-temporal complexity. Little is known about the Golgi apparatus, despite the fact th...
Repository : Europe PubMed Central
Language(s) : English

The role of PML in the control of apoptotic cell fate: a new key player at ER–mitochondria sites

Author(s) : Pinton, P , Giorgi, C , Pandolfi, P P
Description : The development of malignant tumors results from deregulated proliferation or an inability of cells to undergo apoptotic cell death. Experimental works of the past decade have highlighted the importance of calcium (Ca2+) in the regulation of apoptosis. Several studies indicate that the Ca2+ content ...
Repository : Europe PubMed Central
Language(s) : English

A pericentric inversion of chromosome 4 in pigs

Author(s) : Ducos, A , Pinton, A , Séguéla, A , Berland, HM , Blanc, MF , Darré, A , Pinton, P , Yerle, M , Darré, R
Description :
Repository : Europe PubMed Central
Language(s) : English

Mitochondrial Ca2+ signalling: Molecular determinants and physiological role

Author(s) : Rizzuto, R , Pinton, P , Rapizzi, E , Vandecastecle, G , Szabadkai, G
Description :
Repository : UCL Eprints
Language(s) : Undetermined

A pericentric inversion of chromosome 4 in pigs

Author(s) : Ducos A , Pinton A , Séguéla A , Berland HM , Blanc MF , Darré A , Pinton P , Yerle M , Darré R
Description :
Repository : DOAJ-Articles
Language(s) : Undetermined

Overexpression of adenine nucleotide translocase reduces Ca2+ signal transmission between the ER and mitochondria

Author(s) : Wieckowski, MR , Szabadkai, G , Wasilewski, M , Pinton, P , Duszynski, J , Rizzuto, R
Description : The adenine nucleotide translocase (ANT), besides transferring ATP from the mitochondrial matrix to the rest of the cell, has also been proposed to be involved in mitochondrial permeability transition (MPT), and accordingly in mitochondrial Ca2+ homeostasis. In order to assess the role of ANT in Ca2...
Repository : UCL Eprints
Language(s) : Undetermined

Endoplasmic reticulum, Bcl-2 and Ca2+ handling in apoptosis

Author(s) : Ferrari, D , Pinton, P , Szabadkai, G , Chami, M , Campanella, M , Pozzan, T , Rizzuto, R
Description : In the complex signalling interplay that allows extracellular signals to be decoded into activation of apoptotic cell death, Ca2+ plays a significant role. This is supported not only by evidence linking alterations in Ca2+ homeostasis to the triggering of apoptotic (and in some cases necrotic) cell ...
Repository : UCL Eprints
Language(s) : Undetermined

Bcl-2 and Bax exert opposing effects on Ca2+ signaling, which do not depend on their putative pore-forming region

Author(s) : Chami, M , Prandini, A , Campanella, M , Pinton, P , Szabadkai, G , Reed, JC , Rizzuto, R
Description : Recent work has shown that Bcl-2 and other antiapoptotic proteins partially deplete the endoplasmic reticulum (ER) Ca2+ store and that this alteration of Ca2+ signaling reduces cellular sensitivity to apoptotic stimuli. We expressed in HeLa cells Bcl-2, Bax, and Bcl-2/Bax chimeras in which the putat...
Repository : UCL Eprints
Language(s) : Undetermined

Selective modulation of subtype III IP3R by Akt regulates ER Ca2+ release and apoptosis

Author(s) : Marchi, S , Marinello, M , Bononi, A , Bonora, M , Giorgi, C , Rimessi, A , Pinton, P
Description : Ca2+ transfer from endoplasmic reticulum (ER) to mitochondria can trigger apoptotic pathways by inducing release of mitochondrial pro-apoptotic factors. Three different types of inositol 1,4,5-trisphosphate receptor (IP3R) serve to discharge Ca2+ from ER, but possess some peculiarities, especially i...
Repository : Europe PubMed Central
Language(s) : English

VDAC1 selectively transfers apoptotic Ca2+ signals to mitochondria

Author(s) : De Stefani, D , Bononi, A , Romagnoli, A , Messina, A , De Pinto, V , Pinton, P , Rizzuto, R
Description : Voltage-dependent anion channels (VDACs) are expressed in three isoforms, with common channeling properties and different roles in cell survival. We show that VDAC1 silencing potentiates apoptotic challenges, whereas VDAC2 has the opposite effect. Although all three VDAC isoforms are equivalent in a...
Repository : Europe PubMed Central
Language(s) : English
1 2 3 > >>

Found 25 documents, displaying page 1 of 3