Results
author = "Pinton, P"
Calcium and apoptosis: facts and hypotheses
Author(s) :
Rizzuto, R
,
Pinton, P
,
Ferrari, D
,
Chami, M
,
Szabadkai, G
,
Magalhaes, PJ
,
Di Virgilio, F
,
Pozzan, T
Description :
Although longstanding experimental evidence has associated alterations of calcium homeostasis to cell death, only in the past few years the role of calcium in the signaling of apoptosis has been extensively investigated. In this review, we will summarize the current knowledge, focusing on (i) the ef...
Repository :
UCL Eprints
Language(s) :
Undetermined
Recombinant expression of the voltage-dependent anion channel enhances the transfer of Ca2+ microdomains to mitochondria
Author(s) :
Rapizzi, E
,
Pinton, P
,
Szabadkai, G
,
Wieckowski, MR
,
Vandecasteele, G
,
Baird, G
,
Tuft, RA
,
Fogarty, KE
,
Rizzuto, R
Description :
Although the physiological relevance of mitochondrial Ca2+ homeostasis is widely accepted, no information is yet available on the molecular identity of the proteins involved in this process. Here we analyzed the role of the voltage-dependent anion channel (VDAC) of the outer mitochondrial membrane i...
Repository :
UCL Eprints
Language(s) :
Undetermined
Cost effectiveness analysis of drotrecogin alfa (activated) as a treatment for severe sepsis in hospitalised patients
Author(s) :
Launois, R
,
Riou Franca, L
,
Guidet, B
,
Aegerter, P
,
Huet, X
,
Meshaka, P
,
Pinton, P
Description :
Repository :
Europe PubMed Central
Language(s) :
English
The prolyl-isomerase Pin1 activates the mitochondrial death program of p53
Author(s) :
Sorrentino, G
,
Mioni, M
,
Giorgi, C
,
Ruggeri, N
,
Pinton, P
,
Moll, U
,
Mantovani, F
,
Del Sal, G
Description :
In response to intense stress, the tumor protein p53 (p53) tumor suppressor rapidly
mounts a direct mitochondrial death program that precedes transcription-mediated
apoptosis. By eliminating severely damaged cells, this pathway contributes to tumor
suppression as well as to cancer cell killing induc...
Repository :
Europe PubMed Central
Language(s) :
English
Plasma membrane associated membranes (PAM) from Jurkat cells contain STIM1 protein Is PAM involved in the capacitative calcium entry?
Author(s) :
Koziel, K
,
Lebiedzinska, M
,
Szabadkai, G
,
Onopiuk, M
,
Brutkowski, W
,
Wierzbicka, K
,
Wilczynski, G
,
Pinton, P
,
Duszynski, J
Description :
A proper cooperation between the plasma membrane, the endoplasmic reticulum and the mitochondria seems to be essential for numerous cellular processes involved in Call signalling and maintenance of Ca2+ homeostasis. A presence of microsomal and mitochondrial proteins together with those characterist...
Repository :
UCL Eprints
Language(s) :
Undetermined
p66Shc Aging Protein in Control of Fibroblasts Cell Fate
Author(s) :
Suski, JM
,
Karkucinska-Wieckowska, A
,
Lebiedzinska, M
,
Giorgi, C
,
Szczepanowska, J
,
Szabadkai, G
,
Duszynski, J
,
Pronicki, M
Description :
Reactive oxygen species (ROS) are wieldy accepted as one of the main factors of the aging process. These highly reactive compounds modify nucleic acids, proteins and lipids and affect the functionality of mitochondria in the first case and ultimately of the cell. Any agent or genetic modification th...
Repository :
UCL Eprints
Language(s) :
Undetermined
Oxidative stress induced p66Shc phosphorylation in fibroblasts with neuropathy, ataxia and retinitis pigmentosa (NARP) syndrome
Author(s) :
Lebiedzinska, M
,
Karkucinska-Wieckowska, A
,
Suski, JM
,
Szabadkai, G
,
Diogo, CV
,
Wilczynski, G
,
Wlodarczyk, J
,
Pronicki, M
Description :
Repository :
UCL Eprints
Language(s) :
Undetermined
Novel role for polycystin-1 in modulating cell proliferation through calcium oscillations in kidney cells
Author(s) :
Aguiari, G
,
Trimi, V
,
Bogo, M
,
Mangolini, A
,
Szabadkai, G
,
Pinton, P
,
Witzgall, R
,
Harris, PC
,
Borea, PA
,
Rizzuto, R
,
del Senno, L
Description :
Objectives: Polycystin-1 (PC1), a signalling receptor regulating Ca2+-permeable cation channels, is mutated in autosomal dominant polycystic kidney disease, which is typically characterized by increased cell proliferation. However, the precise mechanisms by which PC1 functions on Ca2+ homeostasis, s...
Repository :
UCL Eprints
Language(s) :
Undetermined
Analysis of distribution in the human, pig, and rat genomes points toward a general subtelomeric origin of minisatellite structures (vol 52, pg 62, 1998).
Description :
Repository :
Oxford University Research Archive (ORA)
Language(s) :
Undetermined
Analysis of distribution in the human, pig, and rat genomes points toward a general subtelomeric origin of minisatellite structures.
Description :
We have developed approaches for the cloning of minisatellites from total genomic libraries and applied these approaches to the human, rat, and pig genomes. The chromosomal distribution of minisatellites in the three genomes is strikingly different, with clustering at chromosome ends in human, a see...
Repository :
Oxford University Research Archive (ORA)
Language(s) :
English