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author = "Onyekwere, Onyinye"
1

Found 5 documents, displaying page 1 of 1

Sickle Cell Disease (SCD), iNKT Cells, and Regadenoson Infusion

Author(s) : Nathan, David G. , Field, Joshua , Lin, Gene , Neuberg, Donna , Majerus, Elaine , Onyekwere, Onyinye , Keefer, Jeffrey
Description : A humanized murine sickle cell–disease (SCD) model (NY1DD) has been used to study ischemia/reperfusion injury (IRI) in sickle cell anemia, and iNKT cells (a very small subset of murine and human T cells) have been found to instigate such injury in this model. Furthermore, levels of activated iNKT ce...
Repository : Europe PubMed Central
Language(s) : English

Elevated tricuspid regurgitant jet velocity in children and adolescents with sickle cell disease: association with hemolysis and hemoglobin oxygen desaturation

Author(s) : Minniti, Caterina P. , Sable, Craig , Campbell, Andrew , Rana, Sohail , Ensing, Gregory , Dham, Niti , Onyekwere, Onyinye
Description : An elevated echocardiography-determined tricuspid regurgitant jet velocity predicts high systolic pulmonary artery pressure and early mortality in adults with sickle cell disease. The study provides evidence for independent associations of elevated jet velocity with hemolysis and oxygen desaturation...
Repository : Europe PubMed Central
Language(s) : English

Relationship of erythropoietin, fetal hemoglobin, and hydroxyurea treatment to tricuspid regurgitation velocity in children with sickle cell disease

Author(s) : Gordeuk, Victor R. , Campbell, Andrew , Rana, Sohail , Nouraie, Mehdi , Niu, Xiaomei , Minniti, Caterina P. , Sable, Craig
Description : Hydroxyurea and higher hemoglobin F improve the clinical course and survival in sickle cell disease, but their roles in protecting from pulmonary hypertension are not clear. We studied 399 children and adolescents with sickle cell disease at steady state; 38% were being treated with hydroxyurea. Pat...
Repository : Europe PubMed Central
Language(s) : English

A randomised comparison of deferasirox versus deferoxamine for the treatment of transfusional iron overload in sickle cell disease

Author(s) : Vichinsky, Elliott , Onyekwere, Onyinye , Porter, John , Swerdlow, Paul , Eckman, James , Lane, Peter , Files, Beatrice
Description : Deferasirox is a once-daily, oral iron chelator developed for treating transfusional iron overload. Preclinical studies indicated that the kidney was a potential target organ of toxicity. As patients with sickle cell disease often have abnormal baseline renal function, the primary objective of this ...
Repository : Europe PubMed Central
Language(s) : English

Hospitalization for pain in patients with sickle cell disease treated with sildenafil for elevated TRV and low exercise capacity

Author(s) : Machado, Roberto F. , Barst, Robyn J. , Yovetich, Nancy A. , Hassell, Kathryn L. , Kato, Gregory J. , Gordeuk, Victor R.
Description : In adults with sickle cell disease (SCD), an increased tricuspid regurgitation velocity (TRV) by Doppler echocardiography is associated with increased morbidity and mortality. Although sildenafil has been shown to improve exercise capacity in patients with pulmonary arterial hypertension, it has not...
Repository : Europe PubMed Central
Language(s) : English
1

Found 5 documents, displaying page 1 of 1