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author = "Mullenders, Leon H. F."
<< < 1 2

Found 16 documents, displaying page 2 of 2

Global Phosphoproteome Profiling Reveals Unanticipated Networks Responsive to Cisplatin Treatment of Embryonic Stem Cells ▿ †

Author(s) : Pines, Alex , Kelstrup, Christian D. , Vrouwe, Mischa G. , Puigvert, Jordi C. , Typas, Dimitris , Misovic, Branislav
Description : Cellular responses to DNA-damaging agents involve the activation of various DNA damage signaling and transduction pathways. Using quantitative and high-resolution tandem mass spectrometry, we determined global changes in protein level and phosphorylation site profiles following treatment of SILAC (s...
Repository : Europe PubMed Central
Language(s) : English

Induction of nevi and skin tumors in Ink4a/Arf Xpa knockout mice by neonatal, intermittent, or chronic UVB exposures.

Author(s) : Schanke, Arne van , Venrooij, Gemma M C A L van , Jongsma, Marjan J , Banus, H Alexander , Mullenders, Leon H F , Kranen, Henk J van
Description : Nevi and melanomas correlate to childhood and intermittent solar UV exposure, xeroderma pigmentosum patients run increased risk, and p16(Ink4a) expression is often lost in malignant progression. To ascertain the effect of these risk factors, pigmented hairless Ink4a/Arf-, Xpa- knockout mice were sub...
Repository : Webbased Archive of RIVM Publications
Language(s) : English

Association between transcriptional activity, local chromatin structure, and the efficiencies of both subpathways of nucleotide excision repair of melphalan adducts.

Author(s) : Episkopou, Hara , Kyrtopoulos, Soterios A. , Sfikakis, Petros P. , Fousteri, Maria , Dimopoulos, Meletios A. , Mullenders, Leon H.F.
Description : The repair of melphalan-induced N-alkylpurine monoadducts and interstrand cross-links was examined in different repair backgrounds, focusing on four genes (beta-actin, p53, N-ras, and delta-globin) with dissimilar transcription activities. Adducts were found to be substrates for both global genome r...
Repository : ECNIS Repository (Environmental Cancer Risk, Nutrition and Individual Susceptibility Repository)
Language(s) : English

Replication protein A safeguards genome integrity by controlling NER incision events

Author(s) : Overmeer, René M. , Moser, Jill , Volker, Marcel , Kool, Hanneke , Tomkinson, Alan E. , van Zeeland, Albert A. , Mullenders, Leon H.F.
Description : Continued association of RPA with sites of incomplete nucleotide excision repair averts further incision events until repair is completed.
Repository : Europe PubMed Central
Language(s) : English

Local UV-induced DNA damage in cell nuclei results in local transcription inhibition

Author(s) : Moné, Martijn J. , Volker, Marcel , Nikaido, Osamu , Mullenders, Leon H.F. , van Zeeland, Albert A. , Verschure, Pernette J.
Description : UV-induced DNA damage causes cells to repress RNA synthesis and to initiate nucleotide excision repair (NER). NER and transcription are intimately linked processes. Evidence has been presented that, in addition to damaged genes, undamaged loci are transcriptionally inhibited. We investigated whether...
Repository : Europe PubMed Central
Language(s) : English

Heterochromatin protein 1 is recruited to various types of DNA damage

Author(s) : Luijsterburg, Martijn S. , Dinant, Christoffel , Lans, Hannes , Stap, Jan , Wiernasz, Elzbieta , Lagerwerf, Saskia , Warmerdam, Daniël O.
Description : Heterochromatin protein 1 (HP1) family members are chromatin-associated proteins involved in transcription, replication, and chromatin organization. We show that HP1 isoforms HP1-α, HP1-β, and HP1-γ are recruited to ultraviolet (UV)-induced DNA damage and double-strand breaks (DSBs) in human cells. ...
Repository : Europe PubMed Central
Language(s) : English
<< < 1 2

Found 16 documents, displaying page 2 of 2