Results
author = "Mouton, J.W."
Killing of Pseudomonas aeruginosa during continuous and intermittent infusion of ceftazidime in an in vitro pharmacokinetic model.
Description :
An in vitro pharmacokinetic model mimicking human serum drug concentrations, based on a dialyzer unit, was developed to study the efficacies of continuous infusion and intermittent administration of ceftazidime over a period of 36 h. The daily dose of ceftazidime was 300 mg/liter/24 h given either a...
Repository :
Europe PubMed Central
Language(s) :
English
Pharmacokinetic-pharmacodynamic modeling of activity of ceftazidime during continuous and intermittent infusion.
Description :
We developed and applied pharmacokinetic-pharmacodynamic (PK-PD) models to characterize in vitro bacterial rate of killing as a function of ceftazidime concentrations over time. For PK-PD modeling, data obtained during continuous and intermittent infusion of ceftazidime in Pseudomonas aeruginosa kil...
Repository :
Europe PubMed Central
Language(s) :
English
Use of pharmacodynamic parameters to predict efficacy of combination therapy by using fractional inhibitory concentration kinetics
Description :
Combination therapy with antimicrobial agents can be used against bacteria
that have reduced susceptibilities to single agents. We studied various
tobramycin and ceftazidime dosing regimens against four resistant
Pseudomonas aeruginosa strains in an in vitro pharmacokin...
Repository :
RePub (Erasmus University Repository)
Language(s) :
English
Duration and clinical relevance of postantibiotic effect in relation to the dosing interval
Description :
The influence of half-life on the postantibiotic effect (PAE) of
tobramycin against Pseudomonas aeruginosa and Staphylococcus aureus was
investigated during one dosing interval. Tobramycin half-lives of 0.5 to
2.5 h were simulated in an in vitro model, and the PAE was d...
Repository :
RePub (Erasmus University Repository)
Language(s) :
English
Killing of Pseudomonas aeruginosa during continuous and intermittent infusion of ceftazidime in an in vitro pharmacokinetic model
Description :
An in vitro pharmacokinetic model mimicking human serum drug
concentrations, based on a dialyzer unit, was developed to study the
efficacies of continuous infusion and intermittent administration of
ceftazidime over a period of 36 h. The daily dose of ceftazidime was 30...
Repository :
RePub (Erasmus University Repository)
Language(s) :
English
Is continuous infusion of beta-lactam antibiotics worthwhile?--efficacy and pharmacokinetic considerations
Description :
The most important pharmacodynamic parameter for beta-lactam antibiotics
has been shown to be the time above the MIC, which is used as an argument
to administer beta-lactam antibiotics by continuous infusion. Studies in
vitro and in laboratory animals comparing efficacy...
Repository :
RePub (Erasmus University Repository)
Language(s) :
English
Can group B streptococci cause symptomatic vaginitis?
Description :
BACKGROUND: Maternal cervicovaginal colonization with Lancefield group B streptococci (GBS) is an important risk factor for neonatal morbidity and mortality. About 15% of women are carriers of GBS. Usually, they are asymptomatic. CASES: We describe two patients with symptomatic vaginitis for which n...
Repository :
Europe PubMed Central
Language(s) :
English
Improved efficacy of ciprofloxacin administered in polyethylene glycol-coated liposomes for treatment of Klebsiella pneumoniae pneumonia in rats.
Description :
Animal and clinical data show that high ratios of the area under the
concentration-time curve and the peak concentration in blood to the MIC of
fluoroquinolones for a given pathogen are associated with a favorable
outcome. The present study investigated whether improvem...
Repository :
RePub (Erasmus University Repository)
Language(s) :
English
Alteration of postantibiotic effect during one dosing interval of tobramycin, simulated in an in vitro pharmacokinetic model
Description :
The kinetics of the postantibiotic effect (PAE) during one dosing interval
of tobramycin against Staphylococcus aureus and Pseudomonas aeruginosa was
investigated. We determined the PAE at different time points during this
dosing interval of 12 h in an in vitro pharmaco...
Repository :
RePub (Erasmus University Repository)
Language(s) :
English
Synergism between tobramycin and ceftazidime against a resistant Pseudomonas aeruginosa strain, tested in an in vitro pharmacokinetic model
Description :
Synergism between two antibiotics is usually tested by a checkerboard
titration technique, or by time-kill methods. Both methods have the
disadvantage that synergism is determined at constant concentrations of
the antibiotics, which do not reflect reality in vivo. In th...
Repository :
RePub (Erasmus University Repository)
Language(s) :
English