Results
author = "Moncada, Salvador"
Nitrergic control of peripheral sympathetic responses in the human corpus cavernosum: A comparison with other species
Description :
Noradrenergic contractions induced by electrical field stimulation (EFS) of the rabbit anococcygeus muscle and the human and rabbit corpus cavernosum did not occur until termination of stimulation, even when EFS was applied for long periods (10 min). After treatment with a nitric oxide synthase inhi...
Repository :
Europe PubMed Central
Language(s) :
English
From pollutant gas to biological messenger: the diverse actions of nitric oxide in cancer.
Description :
Nitric oxide (NO) has undergone an image change in recent years. Previously regarded as a toxic pollutant gas, it has now become the subject of intense research in many fields of medicine and science. It is a free radical, with a diverse range of actions in both physiological and pathological proces...
Repository :
Europe PubMed Central
Language(s) :
English
Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway
Description :
El óxido nítrico activa la glucolisis en los astrocitos a través de una cascada de señalización en la que interviene la AMP kinasa, que fosforila (y activa) la fosfofructokinasa-2, enzima responsable de la biosíntesis de fructosa-2, 6-bisfosfato, efector alostérico positivo de la fosfofructokinasa-1...
Repository :
GREDOS: GEstión del REpositorio DOcumental de la Universidad de Salamanca
Language(s) :
English
Elevated Immunoglobulin E against Recombinant Brugia malayi γ-Glutamyl Transpeptidase in Patients with Bancroftian Filariasis: Association with Tropical Pulmonary Eosinophilia or Putative Immunity
Description :
A major allergen of the lymphatic filarial nematode Brugia malayi, a homologue of γ-glutamyl transpeptidase (γ-GT), is involved in the pathology of tropical pulmonary eosinophilia (TPE) through its potent allergenicity and the induction of antibodies against the host pulmonary epithelium. To investi...
Repository :
Europe PubMed Central
Language(s) :
English
On the mechanism by which vascular endothelial cells regulate their oxygen consumption
Description :
Two enzymes, soluble guanylyl cyclase and cytochrome c
oxidase, have been shown to be exquisitely sensitive to nitric
oxide (NO) at low physiological concentrations. Activation of the
soluble guanylyl cyclase by endogenous NO and the
consequent increase in the second messenger cyclic GMP are now...
Repository :
Europe PubMed Central
Language(s) :
English
E3 ubiquitin ligase APC/C-Cdh1 accounts for the Warburg effect by linking glycolysis to cell proliferation
Description :
Cell proliferation is known to be accompanied by activation of glycolysis. We have recently discovered that the glycolysis-promoting enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, isoform 3 (PFKFB3), is degraded by the E3 ubiquitin ligase APC/C-Cdh1, which also degrades cell-cycle prot...
Repository :
Europe PubMed Central
Language(s) :
English
Mitochondria as signaling organelles in the vascular endothelium
Description :
Vascular endothelial cells are highly glycolytic and consume relatively low amounts of oxygen (O2) compared with other cells. We have confirmed that oxidative phosphorylation is not the main source of ATP generation in these cells. We also show that at a low O2 concentration (<1%) endogenous NO play...
Repository :
Europe PubMed Central
Language(s) :
English
Different responses of astrocytes and neurons to nitric oxide: The role of glycolytically generated ATP in astrocyte protection
Description :
It was recently proposed that in Jurkat cells, after inhibition of
respiration by NO, glycolytically generated ATP plays a critical role
in preventing the collapse of mitochondrial membrane potential
(Δψm) and thus apoptotic cell death. We
have investigated this observation further in primary cu...
Repository :
Europe PubMed Central
Language(s) :
English
Persistent inhibition of cell respiration by nitric oxide: Crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione
Description :
Both reversible and irreversible inhibition of mitochondrial respiration have been reported following the generation of nitric oxide (NO) by cells. Using J774 cells, we have studied the effect of long-term exposure to NO on different enzymes of the respiratory chain. Our results show that, although ...
Repository :
Europe PubMed Central
Language(s) :
English
The effect of nitric oxide on cell respiration: A key to understanding its role in cell survival or death
Author(s) :
Beltrán, Belén
,
Mathur, Anthony
,
Duchen, Michael R.
,
Erusalimsky, Jorge D.
,
Moncada, Salvador
Description :
The mitochondrion is a key organelle in the control of cell
death. Nitric oxide (NO) inhibits complex IV in the respiratory chain
and is reported to possess both proapoptotic and
antiapoptotic actions. We investigated the effects of
continuous inhibition of respiration by NO on mitochondrial ene...
Repository :
Europe PubMed Central
Language(s) :
English