Results
author = "Matullo, Giuseppe"
A Proximity-Based Method to Identify Genomic Regions Correlated with a Continuously Varying Environmental Variable
Author(s) :
Di Gaetano, Cornelia
,
Matullo, Giuseppe
,
Piazza, Alberto
,
Ursino, Moreno
,
Gasparini, Mauro
Description :
Knowledge of markers in the human genome which show spatial patterns and display extreme correlation with different environmental determinants play an important role in understanding the factors which affect the biological evolution of our species. We used the genotype data of more than half a milli...
Repository :
Europe PubMed Central
Language(s) :
English
Exposure to the tobacco smoke constituent 4-aminobiphenyl induces chromosomal instability in human cancer cells.
Author(s) :
Saletta, Federica
,
Matullo, Giuseppe
,
Manuguerra, Maurizio
,
Arena, Sabrina
,
Bardelli, Alberto
,
Vineis, Paolo
Description :
The relationships between environmental factors and the genetic abnormalities that drive carcinogenesis are supported by experimental and epidemiologic evidence but their molecular basis has not been fully elucidated. At the genomic level, most human cancers display either chromosomal (CIN) or micro...
Repository :
ECNIS Repository (Environmental Cancer Risk, Nutrition and Individual Susceptibility Repository)
Language(s) :
English
Role of TGF-β1 haplotypes in the occurrence of myocardial infarction in young Italian patients
Author(s) :
Crobu Francesca
,
Palumbo Luigi
,
Franco Erica
,
Bergerone Serena
,
Carturan Sonia
,
Guarrera Simonetta
,
Frea Simone
,
Trevi Gianpaolo
Description :
Abstract
Background
Transforming growth factor beta 1 (TGF-β1) gene play an important role in the acute myocardial infarction (AMI), however no investigation has been conducted so far in young AMI patients.
In this study, we evaluated the influence of TGF-β1 polymorphisms/hap...
Repository :
DOAJ-Articles
Language(s) :
English
Renin-angiotensin-aldosterone system polymorphisms: a role or a hole in occurrence and long-term prognosis of acute myocardial infarction at young age
Author(s) :
Franco Erica
,
Palumbo Luigi
,
Crobu Francesca
,
Anselmino Matteo
,
Frea Simone
,
Matullo Giuseppe
,
Piazza Alberto
,
Trevi Gian
Description :
Abstract
Background
The renin-angiotensin-aldosterone system (RAAS) is involved in the cardiovascular homeostasis as shown by previous studies reporting a positive association between specific RAAS genotypes and an increased risk of myocardial infarction. Anyhow the prognostic role ...
Repository :
DOAJ-Articles
Language(s) :
English
Validation of the nucleotide excision repair comet assay on cryopreserved PBMCs to measure inter-individual variation in DNA repair capacity.
Author(s) :
Allione, Alessandra
,
Russo, Alessia
,
Ricceri, Fulvio
,
Vande Loock, Kim
,
Guarrera, Simonetta
,
Voglino, Floriana
Description :
Inter-individual susceptibility to mutagens/carcinogens can be assessed by either genotyping DNA repair genes in different pathways or phenotyping DNA repair capacity (DRC) at the molecular or cellular level. Due to the large number of known DNA repair genes, and the interactions between repair path...
Repository :
ECNIS Repository (Environmental Cancer Risk, Nutrition and Individual Susceptibility Repository)
Language(s) :
English
Smoking, DNA Adducts and Number of Risk DNA Repair Alleles in Lung Cancer Cases, in Subjects with Benign Lung Diseases and in Controls
Author(s) :
Peluso, Marco
,
Munnia, Armelle
,
Piro, Sara
,
Armillis, Alessandra
,
Ceppi, Marcello
,
Matullo, Giuseppe
,
Puntoni, Riccardo
Description :
Smoke constituents can induce DNA adducts that cause mutations and lead to lung cancer. We have analyzed DNA adducts and polymorphisms in two DNA repair genes, for example, XRCC1 Arg194Trp and Arg399Gln genes and XRCC3 Thr241Met gene, in 34 lung cancer cases in respect to 30 subjects with benign lun...
Repository :
Europe PubMed Central
Language(s) :
English
Renin-angiotensin-aldosterone system polymorphisms: a role or a hole in occurrence and long-term prognosis of acute myocardial infarction at young age
Author(s) :
Franco, Erica
,
Palumbo, Luigi
,
Crobu, Francesca
,
Anselmino, Matteo
,
Frea, Simone
,
Matullo, Giuseppe
,
Piazza, Alberto
Description :
Repository :
Europe PubMed Central
Language(s) :
English
Proteome characterization of a human urothelial cell line resistant to the bladder carcinogen 4-aminobiphenyl
Author(s) :
Pastorelli Roberta
,
Saletta Federica
,
Carpi Donatella
,
Campagna Roberta
,
dell'Osta Carlo
,
Schiarea Silvia
,
Vineis Paolo
Description :
Abstract
Background
The aromatic amine 4-aminobiphenyl (4-ABP) is an environmental and occupational contaminant known to be a major etiological agent of human bladder cancer. 4-ABP metabolites are able to form DNA adducts that may induce mutations and initiate bladder carcinogenesis...
Repository :
DOAJ-Articles
Language(s) :
English
A field synopsis on low-penetrance variants in DNA repair genes and cancer susceptibility.
Author(s) :
Vineis, Paolo
,
Manuguerra, Maurizio
,
Kavvoura, Fotini K.
,
Guarrera, Simonetta
,
Allione, Alessandra
,
Rosa, Fabio
Description :
BACKGROUND: Several genes encoding for DNA repair molecules implicated in maintaining genomic integrity have been proposed as cancer-susceptibility genes. Although efforts have been made to create synopses for specific fields that summarize the data from genetic association studies, such an overview...
Repository :
ECNIS Repository (Environmental Cancer Risk, Nutrition and Individual Susceptibility Repository)
Language(s) :
English
ERCC1 haplotypes modify bladder cancer risk: a case-control study.
Author(s) :
Ricceri, Fulvio
,
Guarrera, Simonetta
,
Sacerdote, Carlotta
,
Polidoro, Silvia
,
Allione, Alessandra
,
Fontana, Dario
Description :
Bladder cancer risk is highly influenced by environmental and/or predisposing genetic factors. In the last decades growing evidence of the major role played by DNA repair systems in the developing of bladder cancer has been provided. To better investigate the involvement of DNA repair genes previous...
Repository :
ECNIS Repository (Environmental Cancer Risk, Nutrition and Individual Susceptibility Repository)
Language(s) :
English