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author = "Martinez, D."
<< < 4 5 6 7 8 > >>

Found 113 documents, displaying page 6 of 12

Ontogeny of GnRH and olfactory neuronal systems in man: novel insights from the investigation of inherited forms of Kallmann's syndrome.

Author(s) : González-Martínez, D , Hu, Y , Bouloux, PM
Description : GnRH embryonic neuronal fate is determined by discreet spatio-temporal expression patterns and interactions of axonal guidance and cell adhesion molecules and extracellular matrix proteins. Expression of several transcription factors, locally derived growth factors and neurotransmitters influence Gn...
Repository : UCL Eprints
Language(s) : English

Cross-talk of anosmin-1, the protein implicated in X-linked Kallmann's syndrome, with heparan sulphate and urokinase-type plasminogen activator.

Author(s) : Hu, Y , González-Martínez, D , Kim, SH , Bouloux, PM
Description : Defective function of anosmin-1, the protein encoded by KAL-1, underlies X-linked Kallmann's syndrome (X-KS), a human hereditary developmental disorder. Anosmin-1 appears to play a role in neurite outgrowth and axon branching, although molecular mechanisms of its action are still unknown. Anosmin-1 ...
Repository : UCL Eprints
Language(s) : English

Viral etiology of age-dependent polioencephalomyelitis in C58 mice.

Author(s) : Martinez, D , Wolanski, B , Tytell, A A , Devlin, R G
Description : The etiology of immune polioencephalomyelitis (IPE) and the mechanisms of resistance to IPE induction were investigated in C58 mice. IPE was found to be induced by a lipid-solvent-sensitive, filterable replicating agent present in line Ib leukemic cell suspensions. IPE was serially transmitted in im...
Repository : Europe PubMed Central
Language(s) : English

Induction of RNA editing at heterologous sites by sequences in apolipoprotein B mRNA.

Author(s) : Driscoll, D M , Lakhe-Reddy, S , Oleksa, L M , Martinez, D
Description : An RNA editing mechanism modifies apolipoprotein B (apo-B) mRNA in the intestine by converting cytosine at nucleotide (nt) 6666 to uracil. To define the sequence requirements for editing, mutant apo-B RNAs were analyzed for the ability to be edited in vitro by enterocyte extracts. Editing was detect...
Repository : Europe PubMed Central
Language(s) : English

Development of an in vitro cloning method for Cowdria ruminantium.

Author(s) : Perez, J M , Martinez, D , Debus, A , Sheikboudou, C , Bensaid, A
Description : Cowdria ruminantium is a tick-borne rickettsia which causes severe disease in ruminants. All studies with C. ruminantium reported so far were carried out with stocks consisting of infective blood collected from reacting animals or from the same stocks propagated in vitro. Cloned isolates are needed ...
Repository : Europe PubMed Central
Language(s) : English

Toxoids of Pseudomonas aeruginosa exotoxin-A: photoaffinity inactivation of purified toxin and purified toxin derivatives.

Author(s) : Callahan, L T , Martinez, D , Marburg, S , Tolman, R L , Galloway, D R
Description : For the preparation of greatly detoxified but highly immunogenic toxoids, two enzymatically active, low-toxicity derivatives of Pseudomonas aeruginosa exotoxin-A were further inactivated by photoaffinity labeling. These derivatives were formed during toxin purification, when a relatively crude toxin...
Repository : Europe PubMed Central
Language(s) : English

Immune responses in mice against herpes simplex virus: mechanisms of protection against facial and ganglionic infections.

Author(s) : Zweerink, H J , Martinez, D , Lynch, R J , Stanton, L W
Description : We performed experiments with mice to determine the nature of the immune response(s) that prevents primary infections of the skin and the trigeminal ganglia with herpes simplex virus. Immunization with infectious herpes simplex virus, inactivated virus, or material enriched for viral glycoproteins p...
Repository : Europe PubMed Central
Language(s) : English

Identification of lactate dehydrogenase-elevating virus as the etiological agent of genetically restricted, age-dependent polioencephalomyelitis of mice.

Author(s) : Martinez, D , Brinton, M A , Tachovsky, T G , Phelps, A H
Description : The etiological agent of genetically restricted, age-dependent polioencephalomyelitis of mice (the ADPE agent) and several isolates of lactate dehydrogenase-elevating virus (LDV) were compared by biological, physical-chemical and antigenic criteria. The data indicate that the ADPE agent is a strain ...
Repository : Europe PubMed Central
Language(s) : English

Analysis of T-cell responses in cattle immunized against heartwater by vaccination with killed elementary bodies of Cowdria ruminantium.

Author(s) : Totté, P , McKeever, D , Martinez, D , Bensaid, A
Description : Cattle were successfully immunized against heartwater with a lysate of Cowdria ruminantium formulated in Freund's adjuvant. Vaccinated animals proved fully resistant to virulent challenge 3 and 10 months after vaccination. For the first time a helper T lymphocyte response to Cowdria antigens was obs...
Repository : Europe PubMed Central
Language(s) : English

Resistance of C58 mice to primary systemic herpes simplex virus infection: macrophage dependence and T-cell independence.

Author(s) : Schlabach, A J , Martinez, D , Field, A K , Tytell, A A
Description : The relative contribution of thymus-derived lymphocytes (T-cells) and of macrophages to resistance to primary infection with herpes simplex virus type 1 (HSV-1) was studied in C58 mice. Resistance was dependent on macrophage competence, but was relatively independent of T-lymphocyte competence. Alth...
Repository : Europe PubMed Central
Language(s) : English
<< < 4 5 6 7 8 > >>

Found 113 documents, displaying page 6 of 12