Results
author = "Martial, Joseph"
Cathepsin D processes human prolactin into multiple 16K-like N-terminal fragments: Study of their antiangiogenic properties and physiological relevance
Author(s) :
Piwnica, David
,
Touraine, Philippe
,
Struman, Ingrid
,
Tabruyn, Sébastien
,
Bolbach, Gerard
,
Clapp, Carmen
,
Martial, Joseph
Description :
16K prolactin (PRL) is the name given to the 16-kDa N-terminal fragment obtained by proteolysis of rat PRL by tissue extracts or cell lysates, in which cathepsin D was identified as the candidate protease. Based on its antiangiogenic activity, 16K PRL is potentially a physiological inhibitor of tumo...
Repository :
ORBi (University of Liège)
Language(s) :
English
The antiangiogenic factor 16K PRL induces programmed cell death in endothelial cells by caspase activation
Author(s) :
Martini, J. F.
,
Piot, C.
,
Humeau, L. M.
,
Struman, Ingrid
,
Martial, Joseph
,
Weiner, R. I.
Description :
We asked whether the antiangiogenic action of 16K human PRL (hPRL), in addition to blocking mitogen-induced vascular endothelial cell proliferation, involved activation of programmed cell death. Treatment with recombinant 16K hPRL increased DNA fragmentation in cultured bovine brain capillary endoth...
Repository :
ORBi (University of Liège)
Language(s) :
English
The HMG-Box Transcription Factor Sox4b Is Required for Pituitary Expression of gata2a and Specification of Thyrotrope and Gonadotrope Cells in Zebrafish.
Author(s) :
Quiroz O'Donova, Yobhana
,
Lopez, Marie-Josée
,
Mavropoulos, A
,
Motte, Patrick
,
Martial, Joseph
,
Hammerschmidt, M
Description :
The pituitary is a complex gland comprising different cell types each secreting specific hormones. The extensive network of signaling molecules and transcription factors required for determination and terminal differentiation of specific cell types is still not fully understood. The SRY-like HMG-box...
Repository :
ORBi (University of Liège)
Language(s) :
English
Solution structure of human prolactin
Author(s) :
Teilum, K.
,
Hoch, J. C.
,
Goffin, Vincent
,
Kinet, Sandrina
,
Martial, Joseph
,
Kragelund, B. B.
Description :
We report the solution structure of human prolactin determined by NMR spectroscopy. Our result is a significant improvement over a previous structure in terms of number and distribution of distance restraints, regularity of secondary structure, and potential energy. More significantly, the structure...
Repository :
ORBi (University of Liège)
Language(s) :
English
S179D-human PRL, a pseudophosphorylated human PRL analog, is an agonist and not an antagonist
Author(s) :
Bernichtein, Sophie
,
Kinet, Sandrina
,
Jeay, Sébastien
,
Llovera, Marta
,
Madern, Dominique
,
Martial, Joseph
,
Kelly, Paul A.
Description :
For many years, our group has been involved in the development of human PRL antagonists. In two recent publications, S179D-human PRL, a human PRL analog designed to mimic a putative S179-phosphorylated human PRL, was reported to be a highly potent antagonist of human PRL-induced proliferation and si...
Repository :
ORBi (University of Liège)
Language(s) :
English
Cloning and expression analysis of an inducible HSP70 gene from tilapia fish
Author(s) :
Molina, Alfredo
,
Biemar, Frédéric
,
Muller, Ferenc
,
Iyengar, Arati
,
Prunet, Patrick
,
Maclean, Norman
,
Martial, Joseph
Description :
We isolated and characterized the tilapia (Oreochromis mossambicus) HSP70 gene, highly homologous to other HSP70 genes. A dramatic increase of tilapia HSP70 mRNA levels was observed after heat shock of whole animals in all organs tested. Reporter constructs were tested for transient expression in ca...
Repository :
ORBi (University of Liège)
Language(s) :
English
Differential expression of two somatostatin genes during zebrafish embryonic development
Author(s) :
Devos, Nathalie
,
Deflorian, Gianluca
,
Biemar, Frédéric
,
Bortolussi, Marino
,
Martial, Joseph
,
Peers, Bernard
,
Argenton, Francesco
Description :
We have identified the cDNAs of two new zebrafish preprosomatostatins, PPSS1 and PPSS3, in addition to the previously cloned PPSS2 (Argenton et al., 1999). PPSS1 is the orthologue of mammalian PPSSs, with a conserved C-terminal SS-14 sequence, PPSS2 is a divergent SS precursor and PPSS3 is a cortist...
Repository :
ORBi (University of Liège)
Language(s) :
English
A panel of biological tests reveals developmental effects of pharmaceutical pollutants on late stage zebrafish embryos.
Author(s) :
Pruvot, Benoist
,
Quiroz, Yobhana
,
Voncken, Audrey
,
Jeanray, Nathalie
,
Piot, Amandine
,
Martial, Joseph
,
Muller, Marc
Description :
Standard toxicological assays using the zebrafish model system evaluate lethality and teratogenicity upon exposure during the first two days after fertilization. We tested the biological effects of several widely used drugs on zebrafish by acute treatment for 24hours starting at late embryonic stage...
Repository :
ORBi (University of Liège)
Language(s) :
English
The ornithine decarboxylase gene is essential for cell survival during early murine development
Author(s) :
Pendeville-Samain, Hélène
,
Carpino, Nick
,
Marine, Jean-Christophe
,
Takahashi, Yukata
,
Muller, Marc
,
Martial, Joseph
Description :
Overexpression and inhibitor studies have suggested that the c-Myc target gene for ornithine decarboxylase (ODC), the enzyme which converts ornithine to putrescine, plays an important role in diverse biological processes, including cell growth, differentiation, transformation, and apoptosis. To expl...
Repository :
ORBi (University of Liège)
Language(s) :
English
Antiangiogenic liposomal gene therapy with 16K human prolactin efficiently reduces tumor growth.
Author(s) :
Kinet, Virginie
,
Nguyen, Ngoc-Quynh-Nhu
,
Sabatel, Céline
,
Blacher, Silvia
,
Noël, Agnès
,
Martial, Joseph
,
Struman, Ingrid
Description :
Human 16K PRL (16K hPRL) is a potent inhibitor of angiogenesis both in vitro and in vivo. It has been shown to prevent tumor growth in three xenograft mouse models. Here we have used a gene transfer method based on cationic liposomes to produce 16K hPRL and demonstrate that 16K hPRL inhibits tumor g...
Repository :
ORBi (University of Liège)
Language(s) :
English