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author = "Marchand-Brynaert, Jacqueline"
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Found 125 documents, displaying page 1 of 13

Protecting group migration in the chemistry of 1-t-butyldimethylsilyl-4-hydroxymethyl-2-azetidinone

Author(s) : Gerard, Sabine , Marchand-Brynaert, Jacqueline
Description : The alkoxide anion derived from 1-t-butyldimethylsilyl-4-hydroxymethyl-2-azetidinone (1) rearranged at -78degreesC into amide anion by N-O migration of the silyl protecting group. The occurrence of this intermediate was proved by quenching with benzyl bromide and phenethyl chloroformate, giving resp...
Repository : DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) : English

A practical synthesis of 2,2-difluoro-3-amino-propanoic acid (alpha,alpha-difluoro-beta-alanine)

Author(s) : Cheguillaume, A , Lacroix, Simon , Marchand-Brynaert, Jacqueline
Description : Reformatsky reaction of ethyl bromodifluoroacetate with N,N-(dibenzyl)-1H-benzotriazolyl-1-methylamine gave fully protected alpha,alpha-difluoro-beta-alanine. Hydrogenolysis and hydrolysis furnished alpha,alpha-difluoro-beta-alanine. Further transformation into N-phthalimido-alpha,alpha-difluoro-bet...
Repository : DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) : English

Reactivity assays of surface hydroxyl chain ends of poly(ethylene terephthalate) (PET) film and membranes using original H-3- and fluorine-labeled derivatization reagents

Author(s) : Mougenot, P , Marchand-Brynaert, Jacqueline
Description : The hydroxyl chain ends (PET-OH) displayed on the surface of poly(ethylene terephthalate) film and track-etched membranes of two different porosities were assayed by derivatization with reagents containing H-3 and fluorine tags. After activation by tosylation, the resulting sulfonate esters (PET-OTs...
Repository : DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) : English

Modular synthesis of bifunctional linkers for materials science

Author(s) : Moreau, Julie , Marchand-Brynaert, Jacqueline
Description : A practical synthesis of α,ω-bifunctional linkers is described that is based on three building blocks, namely, thioctic acid, a spacer-arm of seven ethylene glycol units, and a functional motif dedicated to the selective immobilization of purposely tagged proteins. Such representative motifs are bio...
Repository : DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) : English

12- to 22-membered bridged b-lactams as potential penicillin-binding protein inhibitors

Author(s) : Sliwa, Aline , Dive, Georges , Marchand-Brynaert, Jacqueline
Description :
Repository : ORBi (University of Liège)
Language(s) : English

Novel large ring 1,3 bridged 2-azetidinones as potential inhibitors of penicillin-binding proteins

Author(s) : Urbach, Allan , Dive, Georges , Marchand-Brynaert, Jacqueline
Description :
Repository : ORBi (University of Liège)
Language(s) : English

Synthesis and evaluation of N1/C4-substituted beta-lactams as PPE and HLE inhibitors

Author(s) : Gérard, Stéphane , Galleni, Moreno , Dive, Georges , Marchand-Brynaert, Jacqueline
Description : 4-(Alkylamino)carbonyl-1-(alkoxy)carbonyl-2-azetidinones (9-11) have been prepared in five steps from 4-(benzyloxy)carbonyl-1-(t-butyidimethyl)silyl-2-azetidinone (1). The P-lactam reactivity of 9 has been established by H-1 NMR experiment. Compound 11 was a good reversible inhibitor of PPE and HLE....
Repository : ORBi (University of Liège)
Language(s) : English

Synthesis and evaluation of RGD peptidomimetics aimed at surface bioderivatization of polymer substrates

Author(s) : Boxus, Thierry , Touillaux, Roland , Dive, Georges , Marchand-Brynaert, Jacqueline
Description :
Repository : ORBi (University of Liège)
Language(s) : English

2-Aminopropane-1,2,3-tricarboxylic acid: Synthesis and co-crystallization with the class A beta-lactamase BS3 of Bacillus licheniformis.

Author(s) : Beck, Josephine , Sauvage, Eric , Charlier, Paulette , Marchand-Brynaert, Jacqueline
Description : The title compound 4 has been prepared in four steps from ethylglycinate in 63% overall yield. This amino analog of citric acid has been co-crystallized with the class A beta-lactamase BS3 of Bacillus licheniformis and the structure of the complex fully analyzed by X-ray diffraction. Tris-ethyl amin...
Repository : ORBi (University of Liège)
Language(s) : English

Cell adhesive PET membranes by surface grafting of RGD peptidomimetics.

Author(s) : Biltresse, Stéphane , Attolini, Mireille , Marchand-Brynaert, Jacqueline
Description : A non-peptide mimic of the Arg-Gly Asp (RGD) active sequence of adhesive proteins (such as vitronectin) has been equipped with two different spacer-arms for surface anchorage. The covalent grafting on poly(ethylene terephthalate) (PET) membrane was realized via the activation of the hydroxyl polymer...
Repository : DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) : English
1 2 3 4 5 > >>

Found 125 documents, displaying page 1 of 13