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author = "Mar, Jessica C."
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Found 15 documents, displaying page 2 of 2

Canonical NF-κB Activation Is Essential for Epstein-Barr Virus Latent Membrane Protein 1 TES2/CTAR2 Gene Regulation▿†

Author(s) : Gewurz, Benjamin E. , Mar, Jessica C. , Padi, Megha , Zhao, Bo , Shinners, Nicholas P. , Takasaki, Kaoru , Bedoya, Edward
Description : Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) transforms rodent fibroblasts and is expressed in most EBV-associated malignancies. LMP1 (transformation effector site 2 [TES2]/C-terminal activation region 2 [CTAR2]) activates NF-κB, p38, Jun N-terminal protein kinase (JNK), extracellular s...
Repository : Europe PubMed Central
Language(s) : English

Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth

Author(s) : Zhao, Bo , Zou, James , Wang, Hongfang , Johannsen, Eric , Peng, Chih-wen , Quackenbush, John , Mar, Jessica C. , Morton, Cynthia Casson
Description : Epstein-Barr virus nuclear antigen 2 (EBNA2) regulation of transcription through the cell transcription factor RBPJ is essential for resting B-lymphocyte (RBL) conversion to immortal lymphoblast cell lines (LCLs). ChIP-seq of EBNA2 and RBPJ sites in LCL DNA found EBNA2 at 5,151 and RBPJ at 10,529 si...
Repository : Europe PubMed Central
Language(s) : English

Genome-wide siRNA screen for mediators of NF-κB activation

Author(s) : Gewurz, Benjamin E. , Towfic, Fadi , Mar, Jessica C. , Shinners, Nicholas P. , Takasaki, Kaoru , Zhao, Bo , Cahir-McFarland, Ellen D.
Description : Although canonical NFκB is frequently critical for cell proliferation, survival, or differentiation, NFκB hyperactivation can cause malignant, inflammatory, or autoimmune disorders. Despite intensive study, mammalian NFκB pathway loss-of-function RNAi analyses have been limited to specific protein c...
Repository : Europe PubMed Central
Language(s) : English

Therapeutic Implications of GIPC1 Silencing in Cancer

Author(s) : Chittenden, Thomas W. , Pak, Jane , Rubio, Renee , Cheng, Hailing , Holton, Kristina , Prendergast, Niall , Glinskii, Vladimir
Description : GIPC1 is a cytoplasmic scaffold protein that interacts with numerous receptor signaling complexes, and emerging evidence suggests that it plays a role in tumorigenesis. GIPC1 is highly expressed in a number of human malignancies, including breast, ovarian, gastric, and pancreatic cancers. Suppressio...
Repository : Europe PubMed Central
Language(s) : English

Viral Perturbations of Host Networks Reflect Disease Etiology

Author(s) : Gulbahce, Natali , Yan, Han , Dricot, Amélie , Padi, Megha , Byrdsong, Danielle , Franchi, Rachel , Lee, Deok-Sun , Rozenblatt-Rosen, Orit
Description : Many human diseases, arising from mutations of disease susceptibility genes (genetic diseases), are also associated with viral infections (virally implicated diseases), either in a directly causal manner or by indirect associations. Here we examine whether viral perturbations of host interactome may...
Repository : Europe PubMed Central
Language(s) : English
<< < 1 2

Found 15 documents, displaying page 2 of 2