Results
author = "Manoukian, S."
Average Risks of Breast and Ovarian Cancer Associated with BRCA1 or BRCA2 Mutations Detected in Case Series Unselected for Family History: A Combined Analysis of 22 Studies
Author(s) :
Antoniou, A.
,
Pharoah, P. D. P.
,
Narod, S.
,
Risch, H. A.
,
Eyfjord, J. E.
,
Hopper, J. L.
,
Loman, N.
,
Olsson, H.
,
Johannsson, O.
Description :
Germline mutations in BRCA1 and BRCA2 confer high risks of breast and ovarian cancer, but the average magnitude of these risks is uncertain and may depend on the context. Estimates based on multiple-case families may be enriched for mutations of higher risk and/or other familial risk factors, wherea...
Repository :
Europe PubMed Central
Language(s) :
English
International variation in rates of uptake of preventive options in BRCA1 and BRCA2 mutation carriers
Author(s) :
Metcalfe, K.A.
,
Birenbaum-Carmeli, D.
,
Lubinski, J.
,
Gronwald, J.
,
Lynch, H.
,
Moller, P.
,
Ghadirian, P.
,
Foulkes, W.D.
Description :
Several options for cancer prevention are available for women with a BRCA1 or BRCA2 mutation, including prophylactic surgery, chemoprevention and screening. The authors report on preventive practices in women with mutations from 9 countries and examine differences in uptake according to country. Wom...
Repository :
RePub (Erasmus University Repository)
Language(s) :
English
Hormone therapy and the risk of breast cancer in BRCA1 mutation carriers
Author(s) :
Eisen, A.
,
Lubinski, J.
,
Gronwald, J.
,
Moller, P.
,
Lynch, H.
,
Klijn, J.
,
Kim-Sing, C.
,
Neuhausen, S.L.
,
Gilbert, L.
,
Ghadirian, P.
Description :
Background: Hormone therapy (HT) is commonly given to women to alleviate the climacteric symptoms associated with menopause. There is concern that this treatment may increase the risk of breast cancer. The potential association of HT and breast cancer risk is of particular interest to women who carr...
Repository :
RePub (Erasmus University Repository)
Language(s) :
English
Common Breast Cancer-Predisposition Alleles Are Associated with Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers
Author(s) :
Antoniou, A.C.
,
Spurdle, A.B.
,
Sinilnikova, O.
,
Healey, S.
,
Pooley, K.A.
,
Schmutzler, R.K.
,
Versmold, B.
,
Engel, C.
Description :
Germline mutations in BRCA1 and BRCA2 confer high risks of breast cancer. However, evidence suggests that these risks are modified by other genetic or environmental factors that cluster in families. A recent genome-wide association study has shown that common alleles at single nucleotide polymorphis...
Repository :
RePub (Erasmus University Repository)
Language(s) :
English
Common genetic variants and modification of penetrance of BRCA2-associated breast cancer
Author(s) :
Gaudet, M.M.
,
Kirchhoff, T.
,
Green, T.
,
Vijai, J.
,
Korn, J.M.
,
Guiducci, C.
,
Segrè, A.V.
,
McGee, K.
,
McGuffog, L.
,
kartsonaki, C.
Description :
The considerable uncertainty regarding cancer risks associated with inherited mutations of BRCA2 is due to unknown factors. To investigate whether common genetic variants modify penetrance for BRCA2 mutation carriers, we undertook a two-staged genome-wide association study in BRCA2 mutation carriers...
Repository :
RePub (Erasmus University Repository)
Language(s) :
English
Common Genetic Variants and Modification of Penetrance of BRCA2-Associated Breast Cancer
Author(s) :
Gaudet, M.M.
,
Kirchhoff, T.
,
Green, T.
,
Vijai, J.
,
Korn, J.M.
,
Guiducci, C.
,
Segre, A.V.
,
Mcgee, K.
,
McGuffog, L.
,
Kartsonaki, C.
Description :
Repository :
DSpace at Vrije Universiteit Amsterdam
Language(s) :
Undetermined
Interplay between BRCA1 and RHAMM Regulates Epithelial Apicobasal Polarization and May Influence Risk of Breast Cancer
Author(s) :
Maxwell, C.A.
,
Benitez, J.
,
Gomez-Baldo, L.
,
Osorio, A.
,
Bonifaci, N.
,
Fernandez-Ramires, R.
,
Costes, S.V.
,
Guino, E.
Description :
Repository :
DSpace at Vrije Universiteit Amsterdam
Language(s) :
Undetermined
Exploring the link between MORF4L1 and risk of breast cancer
Author(s) :
Martrat, G.
,
Maxwell, C.A.
,
Tominaga, E.
,
Porta-de-la-Riva, M.
,
Bonifaci, N.
,
Gomez-Baldo, L.
,
Bogliolo, M.
,
Lazaro, C.
Description :
Repository :
DSpace at Vrije Universiteit Amsterdam
Language(s) :
Undetermined
Common breast cancer susceptibility alleles and the risk of breast cancer for BRCA1 and BRCA2 mutation carriers: Implications for risk prediction
Author(s) :
Antoniou, A.C.
,
Beesley, J.
,
McGuffog, L.
,
Sinilnikova, O.
,
Healey, S.
,
Neuhausen, S.L.
,
Ding, Y.C.
,
Rebbeck, T.R.
Description :
The known breast cancer susceptibility polymorphisms in FGFR2, TNRC9/TOX3, MAP3K1, LSP1, and 2q35 confer increased risks of breast cancer for BRCA1 or BRCA2 mutation carriers. We evaluated the associations of 3 additional single nucleotide polymorphisms (SNPs), rs4973768 in SLC4A7/NEK10, rs6504950 i...
Repository :
RePub (Erasmus University Repository)
Language(s) :
English
Genetic variation at 9p22.2 and ovarian cancer risk for BRCA1 and BRCA2 mutation carriers
Author(s) :
Ramus, S.J.
,
kartsonaki, C.
,
Gayther, S.A.
,
Pharoah, P.D.P.
,
Sinilnikova, O.
,
Beesley, J.
,
Chenevix-Trench, G.
,
McGuffog, L.
Description :
Background Germline mutations in the BRCA1 and BRCA2 genes are associated with increased risks of breast and ovarian cancers. Although several common variants have been associated with breast cancer susceptibility in mutation carriers, none have been associated with ovarian cancer susceptibility. A ...
Repository :
RePub (Erasmus University Repository)
Language(s) :
English