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author = "Mande, Shekhar C"
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Found 13 documents, displaying page 2 of 2

Mapping Conformational Transitions in Cyclic AMP Receptor Protein: Crystal Structure and Normal-Mode Analysis of Mycobacterium tuberculosis apo-cAMP Receptor Protein

Author(s) : Kumar, Pramod , Joshi, Dhananjay C. , Akif, Mohd , Akhter, Yusuf , Hasnain, Seyed E. , Mande, Shekhar C.
Description : Cyclic AMP (cAMP) receptor protein, which acts as the sensor of cAMP levels in cells, is a well-studied transcription factor that is best known for allosteric changes effected by the binding of cAMP. Although genetic and biochemical data on the protein are available from several sources, structural ...
Repository : Europe PubMed Central
Language(s) : English

Delineation of key regulatory elements identifies points of vulnerability in the mitogen-activated signaling network

Author(s) : Jailkhani, Noor , Ravichandran, Srikanth , Hegde, Shubhada R. , Siddiqui, Zaved , Mande, Shekhar C. , Rao, Kanury V.S.
Description : Drug development efforts against cancer are often hampered by the complex properties of signaling networks. Here we combined the results of an RNAi screen targeting the cellular signaling machinery, with graph theoretical analysis to extract the core modules that process both mitogenic and oncogenic...
Repository : Europe PubMed Central
Language(s) : English

Facilitated Oligomerization of Mycobacterial GroEL: Evidence for Phosphorylation-Mediated Oligomerization▿ †

Author(s) : Kumar, C. M. Santosh , Khare, Garima , Srikanth, C. V. , Tyagi, Anil K. , Sardesai, Abhijit A. , Mande, Shekhar C.
Description : The distinctive feature of the GroES-GroEL chaperonin system in mediating protein folding lies in its ability to exist in a tetradecameric state, form a central cavity, and encapsulate the substrate via the GroES lid. However, recombinant GroELs of Mycobacterium tuberculosis are unable to act as eff...
Repository : Europe PubMed Central
Language(s) : English
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Found 13 documents, displaying page 2 of 2