Results
author = "Losen, Mario"
Therapeutic approaches for the protection of neurolagical synapses in autoimmunity
Author(s) :
Losen, Mario Rene
Description :
Repository :
Univ. Maastricht
Language(s) :
Undetermined
Immunosuppression of experimental autoimmune myasthenia gravis by mycophenolate mofetil
Author(s) :
Janssen, Sofie P. M.
,
Phernambucq, Marko
,
Martinez-Martinez, Pilar
,
DE BAETS, Marc
,
Losen, Mario
Description :
Currently used non-specific immunosuppresive drugs often require intervention in myasthenia gravis (MG) and clinical improvement varies widely. To analyze the therapeutic effect of mycophenolate mofetil (MMF) in experimental autoimmune MG (EAMG), rats were immunized with acetylcholine receptors (ACh...
Repository :
Document Server@UHasselt
Language(s) :
English
Neuropathy-induced spinal GAP-43 expression is not a main player in the onset of mechanical pain hypersensitivity.
Author(s) :
Jaken, Robby J
,
van Gorp, Sebastiaan
,
Joosten, Elbert A
,
Losen, Mario
,
Martínez-Martínez, Pilar
,
De Baets, Marc
Description :
Structural plasticity within the spinal nociceptive network may be fundamental to the chronic nature of neuropathic pain. In the present study, the spatiotemporal expression of growth-associated protein-43 (GAP-43), a protein which has been traditionally implicated in nerve fiber growth and sproutin...
Repository :
DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) :
English
Low Current-driven Micro-electroporation Allows Efficient In Vivo Delivery of Nonviral DNA into the Adult Mouse Brain
Author(s) :
De Vry, Jochen
,
Martinez-Martinez, Pilar
,
Losen, Mario
,
Bode, Gerard H.
,
Temel, Yasin
,
Steckler, Thomas
,
Steinbusch, Harry W. M.
Description :
Viral gene transfer or transgenic animals are commonly used technologies to alter gene expression in the adult brain, although these approaches lack spatial specificity and are time consuming. We delivered plasmid DNA locally into the brain of adult C57BL/6 mice in vivo by voltage-and current-contro...
Repository :
Document Server@UHasselt
Language(s) :
English
The ceramide transporter and the Goodpasture antigen binding protein: one protein - one function?
Author(s) :
Mencarelli, Chiara
,
Losen, Mario
,
Hammels, Caroline
,
De Vry, Jochen
,
Hesselink, Matthijs K. C.
,
Steinbusch, Harry W. M.
Description :
P>The Goodpasture antigen-binding protein (GPBP) and its splice variant the ceramide transporter (CERT) are multifunctional proteins that have been found to play important roles in brain development and biology. However, the function of GPBP and CERT is controversial because of their involvement in ...
Repository :
Document Server@UHasselt
Language(s) :
English
The auto-antigen repertoire in myasthenia gravis
Author(s) :
Vrolix, Kathleen
,
FRAUSSEN, Judith
,
Molenaar, Peter C.
,
Losen, Mario
,
SOMERS, Veerle
,
STINISSEN, Piet
,
DE BAETS, Marc
Description :
Myasthenia Gravis (MG) is an antibody-mediated autoimmune disorder affecting the postsynaptic membrane of the neuromuscular junction (NMJ). MG is characterized by an impaired signal transmission between the motor neuron and the skeletal muscle cell, caused by auto-antibodies directed against NMJ pro...
Repository :
Document Server@UHasselt
Language(s) :
English
Immortalized B cell lines from multiple sclerosis patients produce monoclonal autoreactive antibodies
Author(s) :
FRAUSSEN, Judith
,
Vrolix, Kathleen
,
Martinez-Martinez, Pilar
,
Losen, Mario
,
Hupperts, Raymond
,
VAN WIJMEERSCH, Bart
Description :
Repository :
Document Server@UHasselt
Language(s) :
English
In vivo electroporation of the central nervous system: A non-viral approach for targeted gene delivery
Author(s) :
De Vry, Jochen
,
Martinez-Martinez, Pilar
,
Losen, Mario
,
Temel, Yasin
,
Steckler, Thomas
,
Steinbusch, Harry W. M.
Description :
Electroporation is a widely used technique for enhancing the efficiency of DNA delivery into cells. Application of electric pulses after local injection of DNA temporarily opens cell membranes and facilitates DNA uptake. Delivery of plasmid DNA by electroporation to alter gene expression in tissue h...
Repository :
Document Server@UHasselt
Language(s) :
English
Silencing rapsyn in vivo decreases acetylcholine receptors and augments sodium channels and secondary postsynaptic membrane folding
Author(s) :
Martinez-Martinez, Pilar
,
Phemambucq, Marko
,
Steinbusch, Laura
,
Schaeffer, Laurent
,
Berrih-Aknin, Sonia
,
Duimel, Hans
Description :
The receptor-associated protein of the synapse (rapsyn) is required for anchoring and stabilizing the nicotinic acetylcholine receptor (AChR) in the postsynaptic membrane of the neuromuscular junction (NMJ) during development. Here we studied the role of rapsyn in the maintenance of the adult NMJ by...
Repository :
Document Server@UHasselt
Language(s) :
English
Overexpression of Rapsyn in Rat Muscle Increases Acetylcholine Receptor Levels in Chronic Experimental Autoimmune Myasthenia Gravis
Author(s) :
Martínez-Martínez, Pilar
,
Losen, Mario
,
Duimel, Hans
,
Frederik, Peter
,
Spaans, Frank
,
Molenaar, Peter
,
Vincent, Angela
Description :
The primary autoantigen in myasthenia gravis, the acetylcholine receptor (AChR), is clustered and anchored in the postsynaptic membrane of the neuromuscular junction by rapsyn. Previously, we found that overexpression of rapsyn by cDNA transfection protects AChRs in rat muscles from antibody-mediate...
Repository :
Europe PubMed Central
Language(s) :
English