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author = "Lorenzi, Philip L."
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Found 2 documents, displaying page 1 of 1

Multiplexing siRNAs to compress RNAi-based screen size in human cells

Author(s) : Martin, Scott E. , Jones, Tamara L. , Thomas, Cheryl L. , Lorenzi, Philip L. , Nguyen, Dac A. , Runfola, Timothy , Gunsior, Michele
Description : Here we describe a novel strategy using multiplexes of synthetic small interfering RNAs (siRNAs) corresponding to multiple gene targets in order to compress RNA interference (RNAi) screen size. Before investigating the practical use of this strategy, we first characterized the gene-specific RNAi ind...
Repository : Europe PubMed Central
Language(s) : English

Cellular Inhibition of Checkpoint Kinase 2 (Chk2) and Potentiation of Camptothecins and Radiation by the Novel Chk2 Inhibitor PV1019 [7-Nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide]

Author(s) : Jobson, Andrew G. , Lountos, George T. , Lorenzi, Philip L. , Llamas, Jenny , Connelly, John , Cerna, David , Tropea, Joseph E.
Description : Chk2 is a checkpoint kinase involved in the ataxia telangiectasia mutated pathway, which is activated by genomic instability and DNA damage, leading to either cell death (apoptosis) or cell cycle arrest. Chk2 provides an unexplored therapeutic target against cancer cells. We recently reported 4,4′-d...
Repository : Europe PubMed Central
Language(s) : English
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Found 2 documents, displaying page 1 of 1